Viral Causes of Cancer

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Questions and Answers

Which virus is also known as HHV?

  • Hepatitis B virus
  • Kaposi's sarcoma-associated herpesvirus (KSHV) (correct)
  • Human Papillomavirus (HPV)
  • Hepatitis C virus

Which gene of HPV is responsible for viral replication?

  • E1 (correct)
  • E2
  • E5
  • E4

Which protein encoded by HPV interacts with growth factor receptors?

  • E2
  • E4
  • E1
  • E5 (correct)

Which gene of HPV causes p53 degradation?

<p>E6 (A)</p> Signup and view all the answers

Which gene of HPV interferes with Rb binding?

<p>E7 (C)</p> Signup and view all the answers

Which type of genetic mutations are usually a gain of function and dominant?

<p>Oncogene mutations (D)</p> Signup and view all the answers

Which type of genetic mutations are usually a loss of function and recessive?

<p>Tumor suppressor gene mutations (C)</p> Signup and view all the answers

Which chromosome translocation is associated with Chronic Myelogenous Leukemia (CML)?

<p>t(9;22)(q34;q11) (C)</p> Signup and view all the answers

Which gene is brought under the transcriptional control of the IG enhancer elements in Burkitt's Lymphoma?

<p>MYC (C)</p> Signup and view all the answers

Which mutation results in a change to a stop codon?

<p>Nonsense mutation (A)</p> Signup and view all the answers

Which trinucleotide repeat disease is caused by excessive amplification of a base triplet normally repeated only a few to 50 times?

<p>Fragile X syndrome (C)</p> Signup and view all the answers

Which virus is associated with Burkitt's Lymphoma?

<p>Epstein-Barr virus (EBV) (B)</p> Signup and view all the answers

Which type of mutagen specifically leads to the development of cancer?

<p>Carcinogen (C)</p> Signup and view all the answers

Which type of mutation is present throughout a person's life in virtually every cell in the body?

<p>Inherited mutation (D)</p> Signup and view all the answers

Which type of mutation occurs only in certain cells, not in every cell in the body?

<p>Somatic mutation (D)</p> Signup and view all the answers

Which type of mutation is present in the parent's egg or sperm cells?

<p>Germline mutation (C)</p> Signup and view all the answers

Which type of mutation can be caused by environmental factors such as ultraviolet radiation from the sun?

<p>Acquired mutation (D)</p> Signup and view all the answers

Which type of chromosomal structure abnormality involves the loss of a segment of a chromosome?

<p>Deletions (A)</p> Signup and view all the answers

Which type of chromosomal structure abnormality involves the duplication of a segment of a chromosome?

<p>Duplications (A)</p> Signup and view all the answers

Which type of cancer rapidly develops from the immature cells of a retina?

<p>Retinoblastoma (D)</p> Signup and view all the answers

During the M-to-G1 transition, pRb is progressively dephosphorylated by which enzyme?

<p>PP1 (B)</p> Signup and view all the answers

Which substitution occurs in the TP53 gene at codon position 72?

<p>Arginine for proline (D)</p> Signup and view all the answers

Which cancer is associated with the TP53 codon 72 polymorphism?

<p>Lung cancer (C)</p> Signup and view all the answers

Which genotype of the p53 gene is associated with an increased risk for renal cell carcinoma?

<p>Pro/Pro (C)</p> Signup and view all the answers

Which type of genetic rearrangement occurs within the coding sequence of the proto-oncogene in chronic myeloid leukemia (CML)?

<p>c-abl/bcr (D)</p> Signup and view all the answers

Which physiological process involves the formation of new blood vessels from pre-existing vessels?

<p>Angiogenesis (D)</p> Signup and view all the answers

Which molecules are involved in cell migration, proliferation, and adhesion in angiogenesis?

<p>VEGF, VEGF-R, angiopoietin-2 (B)</p> Signup and view all the answers

Which type of mutation is associated with the initiation of colon carcinogenesis?

<p>Mutation of colon cancer genes (MCC) (D)</p> Signup and view all the answers

What is the process called when there is a selection for more aggressive cells in colon cancer?

<p>Clonal selection (C)</p> Signup and view all the answers

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