Viral Causes of Cancer
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Questions and Answers

Which virus is also known as HHV?

  • Hepatitis B virus
  • Kaposi's sarcoma-associated herpesvirus (KSHV) (correct)
  • Human Papillomavirus (HPV)
  • Hepatitis C virus
  • Which gene of HPV is responsible for viral replication?

  • E1 (correct)
  • E2
  • E5
  • E4
  • Which protein encoded by HPV interacts with growth factor receptors?

  • E2
  • E4
  • E1
  • E5 (correct)
  • Which gene of HPV causes p53 degradation?

    <p>E6</p> Signup and view all the answers

    Which gene of HPV interferes with Rb binding?

    <p>E7</p> Signup and view all the answers

    Which type of genetic mutations are usually a gain of function and dominant?

    <p>Oncogene mutations</p> Signup and view all the answers

    Which type of genetic mutations are usually a loss of function and recessive?

    <p>Tumor suppressor gene mutations</p> Signup and view all the answers

    Which chromosome translocation is associated with Chronic Myelogenous Leukemia (CML)?

    <p>t(9;22)(q34;q11)</p> Signup and view all the answers

    Which gene is brought under the transcriptional control of the IG enhancer elements in Burkitt's Lymphoma?

    <p>MYC</p> Signup and view all the answers

    Which mutation results in a change to a stop codon?

    <p>Nonsense mutation</p> Signup and view all the answers

    Which trinucleotide repeat disease is caused by excessive amplification of a base triplet normally repeated only a few to 50 times?

    <p>Fragile X syndrome</p> Signup and view all the answers

    Which virus is associated with Burkitt's Lymphoma?

    <p>Epstein-Barr virus (EBV)</p> Signup and view all the answers

    Which type of mutagen specifically leads to the development of cancer?

    <p>Carcinogen</p> Signup and view all the answers

    Which type of mutation is present throughout a person's life in virtually every cell in the body?

    <p>Inherited mutation</p> Signup and view all the answers

    Which type of mutation occurs only in certain cells, not in every cell in the body?

    <p>Somatic mutation</p> Signup and view all the answers

    Which type of mutation is present in the parent's egg or sperm cells?

    <p>Germline mutation</p> Signup and view all the answers

    Which type of mutation can be caused by environmental factors such as ultraviolet radiation from the sun?

    <p>Acquired mutation</p> Signup and view all the answers

    Which type of chromosomal structure abnormality involves the loss of a segment of a chromosome?

    <p>Deletions</p> Signup and view all the answers

    Which type of chromosomal structure abnormality involves the duplication of a segment of a chromosome?

    <p>Duplications</p> Signup and view all the answers

    Which type of cancer rapidly develops from the immature cells of a retina?

    <p>Retinoblastoma</p> Signup and view all the answers

    During the M-to-G1 transition, pRb is progressively dephosphorylated by which enzyme?

    <p>PP1</p> Signup and view all the answers

    Which substitution occurs in the TP53 gene at codon position 72?

    <p>Arginine for proline</p> Signup and view all the answers

    Which cancer is associated with the TP53 codon 72 polymorphism?

    <p>Lung cancer</p> Signup and view all the answers

    Which genotype of the p53 gene is associated with an increased risk for renal cell carcinoma?

    <p>Pro/Pro</p> Signup and view all the answers

    Which type of genetic rearrangement occurs within the coding sequence of the proto-oncogene in chronic myeloid leukemia (CML)?

    <p>c-abl/bcr</p> Signup and view all the answers

    Which physiological process involves the formation of new blood vessels from pre-existing vessels?

    <p>Angiogenesis</p> Signup and view all the answers

    Which molecules are involved in cell migration, proliferation, and adhesion in angiogenesis?

    <p>VEGF, VEGF-R, angiopoietin-2</p> Signup and view all the answers

    Which type of mutation is associated with the initiation of colon carcinogenesis?

    <p>Mutation of colon cancer genes (MCC)</p> Signup and view all the answers

    What is the process called when there is a selection for more aggressive cells in colon cancer?

    <p>Clonal selection</p> Signup and view all the answers

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