lecture 24- immunology

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Questions and Answers

Which immune response is responsible for the rapid production of type 1 interferons following viral infection?

  • Cytotoxic T lymphocytes (CTLs)
  • Antibodies
  • Innate immune response (correct)
  • Natural killer (NK) cells

What happens around day 5 of viral infection according to the text?

  • Virus-specific cytotoxic T lymphocytes (CTLs) reach a plateau (correct)
  • The innate immune response is activated
  • Antibody levels decrease
  • The initial exposure to the virus occurs

During the early innate immune response (Days 0-2), what is the role of natural killer (NK) cells?

  • Producing antibodies
  • Attacking infected cells (correct)
  • Slowing down viral replication
  • Releasing more viruses

When do virus-specific antibodies begin to be produced according to the text?

<p>Days 5 and Beyond (D)</p> Signup and view all the answers

What do virus-specific CTLs continue to do as infected cells are targeted and destroyed?

<p>Increase in activity and reach a plateau (B)</p> Signup and view all the answers

What is the role of type 1 interferons in the context of viral infections?

<p>Induce an antiviral state in cells (B)</p> Signup and view all the answers

What is the main function of antibodies after the virus has been eliminated from the body?

<p>Provide a degree of long-term immunity (B)</p> Signup and view all the answers

Which mechanism involves the activation of innate immune responses via pattern recognition receptor activation?

<p>Interferon production by infected cells (B)</p> Signup and view all the answers

How do antibodies contribute to protection against viral infections?

<p>Block binding of virus to its receptor (D)</p> Signup and view all the answers

What is a key role of type 1 interferons in combating viral infections?

<p>Inducing antiviral state in cells (B)</p> Signup and view all the answers

What is the main role of antibodies in limiting the spread of viruses?

<p>Preventing viruses from attaching to host cells (C)</p> Signup and view all the answers

Which process involves antibodies marking virus-infected cells for destruction by immune cells?

<p>Antibody-dependent cell-mediated cytotoxicity (ADCC) (B)</p> Signup and view all the answers

Which immune cells use the same mechanisms for killing virus-infected cells?

<p>Natural killer cells (NKs) and cytotoxic T lymphocytes (CTLs) (B)</p> Signup and view all the answers

What is the main limitation of antibodies in combating established viral infections within host cells?

<p>Inability to neutralize viruses once inside host cells (D)</p> Signup and view all the answers

Which receptors play a key role in recognizing viral patterns during an infection?

<p>Toll-like receptors (TLRs) (C)</p> Signup and view all the answers

What is the role of type 1 interferons in the antiviral defense mechanism?

<p>They communicate the presence of a viral infection to neighboring cells. (D)</p> Signup and view all the answers

Which receptors detect unique patterns or structures associated with viruses in infected cells?

<p>Pattern recognition receptors (PRRs) (A)</p> Signup and view all the answers

What is the primary function of IFNs in the cytokine-induced antiviral state?

<p>Communicate the presence of a viral infection to neighboring cells (A)</p> Signup and view all the answers

Which of the following is NOT a function of the innate immune response against viral infections?

<p>Producing antibodies to neutralize viral particles (C)</p> Signup and view all the answers

How do type 1 interferons affect adjacent uninfected cells in the context of a viral infection?

<p>They bind to interferon receptors on these cells, inducing an antiviral state. (D)</p> Signup and view all the answers

What is the primary role of type 1 interferons in limiting viral spread within the body?

<p>Slowing down viral replication within host cells (B)</p> Signup and view all the answers

What is the main function of antibodies in the context of viral infections?

<p>Neutralizing viral particles to prevent infection (C)</p> Signup and view all the answers

Which immune response provides a more targeted and specific defense against pathogens after the initial innate immune response?

<p>Antigen-specific immunity (A)</p> Signup and view all the answers

What is the fate of viral particles tagged by antibodies for destruction by immune cells like macrophages or neutrophils?

<p>They undergo phagocytosis (B)</p> Signup and view all the answers

How do antibodies primarily prevent the spread of viruses within the body?

<p>By inhibiting viral entry into host cells (C)</p> Signup and view all the answers

What is the primary function of spike proteins on the surface of a coronavirus?

<p>Interact with ACE2 receptors on host cells (A)</p> Signup and view all the answers

How does excessive inflammation during a viral infection contribute to the severity of illness?

<p>It leads to tissue damage (D)</p> Signup and view all the answers

In the context of viral infections, what triggers the body's inflammation response?

<p>Direct damage to cells by the virus (A)</p> Signup and view all the answers

How does a coronavirus evade the host immune response during infection?

<p>By mutating spike proteins to avoid detection (A)</p> Signup and view all the answers

What is the critical balance highlighted in the text related to viral infections and immune responses?

<p>Balance between pro-inflammatory and anti-inflammatory cytokines (A)</p> Signup and view all the answers

How do viruses enter host cells?

<p>By receptor-mediated endocytosis (A)</p> Signup and view all the answers

What is the main purpose of viruses utilizing host cell machinery for nucleic acid and protein synthesis?

<p>To produce more viral particles (C)</p> Signup and view all the answers

Why are viruses considered obligatory intracellular microorganisms?

<p>Because they cannot survive outside of host cells (D)</p> Signup and view all the answers

What is the primary function of virus-specific CTLs in infected individuals?

<p>Recognize and kill infected cells (D)</p> Signup and view all the answers

Which process do viruses use to escape into the cytosol once inside host cells?

<p>Lysis (A)</p> Signup and view all the answers

What is the initial step for viruses to infect host cells?

<p>Binding to specific receptors on host cells (B)</p> Signup and view all the answers

Why do viruses induce tissue damage indirectly according to the text?

<p>By triggering host inflammatory responses (A)</p> Signup and view all the answers

What role do host cell surface proteins play in the infection mechanism of viruses?

<p>They act as receptors for viral entry (B)</p> Signup and view all the answers

Why are viruses commonly referred to as microorganisms or microbes despite being debatable as organisms?

<p>Because they can only replicate within host cells (A)</p> Signup and view all the answers

What distinguishes viruses from other microorganisms?

<p>Their reliance on host cell machinery for replication (A)</p> Signup and view all the answers

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