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Questions and Answers
What is the function of the M protein?
What is the function of the M protein?
Which of the following statements accurately describes the difference between a lytic and a lysogenic virus?
Which of the following statements accurately describes the difference between a lytic and a lysogenic virus?
In the context of viral replication, what is the role of recombination?
In the context of viral replication, what is the role of recombination?
What is the difference between reassortment and complementation?
What is the difference between reassortment and complementation?
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Which statement best describes phenotypic mixing?
Which statement best describes phenotypic mixing?
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What are the four main routes of entry for viruses into the human body?
What are the four main routes of entry for viruses into the human body?
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Which of the following is NOT a physiological route of viral spread?
Which of the following is NOT a physiological route of viral spread?
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Which type of viral infection is characterized by continuous shedding of virus particles after an acute illness, sometimes without host death, and is usually caused by RNA viruses?
Which type of viral infection is characterized by continuous shedding of virus particles after an acute illness, sometimes without host death, and is usually caused by RNA viruses?
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Which of the following is an example of a virus that can spread through both skin and neural routes?
Which of the following is an example of a virus that can spread through both skin and neural routes?
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Which of the following is an example of a viral infection that is considered a latent infection?
Which of the following is an example of a viral infection that is considered a latent infection?
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What is the name of the cellular stress response that involves the sequestration and degradation of viruses within cytoplasmic organelles?
What is the name of the cellular stress response that involves the sequestration and degradation of viruses within cytoplasmic organelles?
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Which type of immune cell is responsible for the destruction of virus-infected cells?
Which type of immune cell is responsible for the destruction of virus-infected cells?
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Which of the following is NOT an example of an extrinsic protective mechanism against viral infection?
Which of the following is NOT an example of an extrinsic protective mechanism against viral infection?
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What are the two main ways that viruses can spread among people?
What are the two main ways that viruses can spread among people?
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What is the term used to describe the presence of a high concentration of virus particles in the bloodstream?
What is the term used to describe the presence of a high concentration of virus particles in the bloodstream?
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Which of the following statements accurately describes the role of bacteriophages in ecosystems?
Which of the following statements accurately describes the role of bacteriophages in ecosystems?
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Why are viruses considered neither prokaryotic nor eukaryotic?
Why are viruses considered neither prokaryotic nor eukaryotic?
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What is the significance of the "spillover event" in the context of viral infections?
What is the significance of the "spillover event" in the context of viral infections?
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Which of the following is NOT considered a route of entry for viruses into the body?
Which of the following is NOT considered a route of entry for viruses into the body?
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What is the primary function of the viral capsid?
What is the primary function of the viral capsid?
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What is the fundamental difference between positive-sense RNA viruses and negative-sense RNA viruses?
What is the fundamental difference between positive-sense RNA viruses and negative-sense RNA viruses?
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Which of the following is NOT a potential outcome of viral infection?
Which of the following is NOT a potential outcome of viral infection?
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Why is it important to understand the structure of a virus?
Why is it important to understand the structure of a virus?
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Which of the following viruses are LEAST likely to be transmitted by an airborne route?
Which of the following viruses are LEAST likely to be transmitted by an airborne route?
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What is the structural difference between adenoviruses and reoviruses?
What is the structural difference between adenoviruses and reoviruses?
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Which of the following statements accurately describes the role of glycoproteins in viral infection?
Which of the following statements accurately describes the role of glycoproteins in viral infection?
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Which of the following statements describes the key difference between enveloped and nonenveloped viruses?
Which of the following statements describes the key difference between enveloped and nonenveloped viruses?
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What is the primary function of the viral envelope?
What is the primary function of the viral envelope?
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Which of the following features is NOT characteristic of icosahedral capsids?
Which of the following features is NOT characteristic of icosahedral capsids?
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Why are certain glycoproteins referred to as hemagglutinins?
Why are certain glycoproteins referred to as hemagglutinins?
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Which of the following statements is TRUE regarding the classification of viruses based on their morphology?
Which of the following statements is TRUE regarding the classification of viruses based on their morphology?
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What is the difference between a nucleocapsid and a capsid?
What is the difference between a nucleocapsid and a capsid?
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What is the significance of glycoproteins as major antigens?
What is the significance of glycoproteins as major antigens?
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Which of the following statements correctly describes the role of attachment proteins in viral infection?
Which of the following statements correctly describes the role of attachment proteins in viral infection?
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During the entry stage of viral infection, what are the two primary mechanisms by which a virion can enter a host cell?
During the entry stage of viral infection, what are the two primary mechanisms by which a virion can enter a host cell?
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What is the primary function of uncoating in the viral infection cycle?
What is the primary function of uncoating in the viral infection cycle?
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What is the main difference between the synthesis of viral proteins and nucleic acids in DNA viruses and RNA viruses?
What is the main difference between the synthesis of viral proteins and nucleic acids in DNA viruses and RNA viruses?
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Which of the following statements correctly describes the role of RNA-dependent RNA polymerase in the replication of RNA viruses?
Which of the following statements correctly describes the role of RNA-dependent RNA polymerase in the replication of RNA viruses?
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What is the key difference between positive-sense and negative-sense RNA viruses?
What is the key difference between positive-sense and negative-sense RNA viruses?
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Why are naked positive-sense viral genomes considered infectious?
Why are naked positive-sense viral genomes considered infectious?
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What is the significance of 'tissue tropism' in viral infection?
What is the significance of 'tissue tropism' in viral infection?
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Which of the following statements accurately describes the role of 'immediate-early' and 'early' transcription in DNA viral replication?
Which of the following statements accurately describes the role of 'immediate-early' and 'early' transcription in DNA viral replication?
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What is the primary function of 'late' transcription in DNA viral replication?
What is the primary function of 'late' transcription in DNA viral replication?
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Flashcards
Viral Diversity
Viral Diversity
Over 1.7 million undiscovered viruses exist in mammals and birds.
Spillover Event
Spillover Event
When viruses transfer from animals to humans, potentially causing outbreaks.
Importance of Viruses
Importance of Viruses
Most viruses support ecosystems and aren't harmful to humans.
Bacteriophages
Bacteriophages
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Viral Life Cycle
Viral Life Cycle
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RNA vs DNA Viruses
RNA vs DNA Viruses
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Intrinsic Protective Mechanisms
Intrinsic Protective Mechanisms
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Viral Structure Basics
Viral Structure Basics
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Icosahedral Capsid
Icosahedral Capsid
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Helical Nucleocapsid
Helical Nucleocapsid
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Nucleocapsid
Nucleocapsid
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Viral Envelope
Viral Envelope
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Nonenveloped Virus
Nonenveloped Virus
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Enveloped Virus
Enveloped Virus
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Virus Associated Pyramids (VAPs)
Virus Associated Pyramids (VAPs)
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Spike Glycoproteins
Spike Glycoproteins
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Glycoproteins
Glycoproteins
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VIRION
VIRION
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Negative-sense RNA
Negative-sense RNA
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Recombination
Recombination
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Reassortment
Reassortment
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Complementation
Complementation
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Lytic vs. Lysogenic viruses
Lytic vs. Lysogenic viruses
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Attachment
Attachment
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Naked viruses
Naked viruses
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Entry
Entry
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Uncoating
Uncoating
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Synthesis of proteins & nucleic acids
Synthesis of proteins & nucleic acids
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DNA viruses
DNA viruses
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RNA viruses
RNA viruses
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Positive-sense strand viruses
Positive-sense strand viruses
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Negative-sense strand viruses
Negative-sense strand viruses
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Capsid Shapes
Capsid Shapes
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Virus Entry Routes
Virus Entry Routes
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Exogenous Virus
Exogenous Virus
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Endogenous Virus
Endogenous Virus
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Vertical Spread
Vertical Spread
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Horizontal Spread
Horizontal Spread
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Incubation Period
Incubation Period
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Types of Viral Infections
Types of Viral Infections
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Neutralizing Antibodies
Neutralizing Antibodies
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Study Notes
Viral Structure
- Viruses are neither prokaryotic nor eukaryotic.
- Viruses lack the characteristics of life as they cannot reproduce independently.
- Viruses are obligate intracellular parasites.
- Viruses have a capsid (single or double protein layer).
- Nucleic acid (RNA or DNA) in the core
- Glycoproteins on the outer surface of envelopes (if present)
- Icosahedral (soccer ball shape) and helical.
- Viruses are measured in nanometers (nm).
- Poliovirus - 32 nm
- Rotavirus - 100 nm
- Human papillomavirus - 60 nm
- Adenovirus - 110 nm
- Semliki Forest virus - 70 nm
- Influenza virus - 80-120 nm
- Paramyxovirus - 150-350 nm
- Smallpox virus - 200 x 300 nm
Viral Classification
- Viruses classified by structure, biochemical characteristics, and type of replication.
- Examples include Picornavirus, Togavirus, Retrovirus, Adenovirus, Reovirus.
Viral Life Cycle
- Viruses have a specific life cycle.
- 6 essential stages are:
- Attachment
- Entry
- Uncoating
- Synthesis of protein & nucleic acid
- Assembly
- Release
Viral Genetics
- Viral genomes can be DNA or RNA.
- Various mechanisms exist. They include recombination, reassortment, and complementation.
- Also, phenotypic mixing occurs.
Viral Properties and Consequences
- Viruses are not living.
- Viruses must be infectious to endure in nature.
- Viruses must use host cells to produce their components (mRNA, protein).
- Viruses must encode any processes not provided by the host cell.
- Viral components self-assemble.
- Viral morphology varies and depends on the type of virus.
Types of Viral Infections
- Acute infection: Virus undergoes multiple rounds of replication.
- Chronic infection: Virus replicates but host does not successfully eliminate them.
- Latent infection: Virus does not produce progeny.
Viral Damage
- Interactions between host and virus lead to the development of signs and symptoms.
- Intrinsic and extrinsic protective mechanisms exist within the host and prevent damage.
Preventative Measures
- Vaccination is a key preventative measure.
- Other preventive steps include hand-washing, avoiding sick individuals, wearing masks, and staying home when sick.
Encounter & Entry
- Viruses enter the body through four main routes: respiratory, gastrointestinal, transcutaneous, or sexual.
- Viral diseases come either from the environment (exogenous) or from within the host (endogenous).
Spread & Replication
- Viruses spread via vertical (during pregnancy) or horizontal transmission among members of the host population (person-to-person).
- The virus replicates via various pathways (neural, hematogenous).
Test your knowledge!
- There are two main capsid shapes: Icosahedral & helical.
- There are 6 main steps of viral replication: Attachment, Entry, Uncoating, Synthesis of protein & nucleic acid, Assembly, and release.
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Description
Test your knowledge on viral structures and functions, including the role of various proteins and viral replication mechanisms. This quiz covers topics such as lytic and lysogenic viruses, routes of viral spread, and types of viral infections. Perfect for students studying virology or related fields.