9 Questions
Match the following with the correct description: Class I fusion proteins
Resistant cell = Cells that have no receptor for a given virus Class I fusion proteins = Proteins that mediate fusion at neutral pH in endosomes Permissive cell = Cells that have the capacity to replicate virus Virus entry = The process of a virus infecting a host cell
Match the following with the correct description: Acid-catalyzed membrane fusion
Attachment = Step where viruses adhere to cell surface randomly Acid-catalyzed membrane fusion = Proteins that mediate fusion at low pH in endosomes Susceptible cell = Cells that have functional receptors for a virus Gene expression = Step in the infectious cycle involving viral mRNA production and translation
Match the following with the correct description: Class II fusion proteins
Viral entry mechanisms = Various ways viruses enter host cells Class II fusion proteins = Proteins that mediate fusion at acidic pH in lysosomes Infectious cycle = The series of steps a virus takes to replicate inside a host cell Assembly and release = Step in the infectious cycle involving viral particles being put together and released from the cell
Match the following with their characteristics:
Class I fusion proteins = Mostly α-helical Class II fusion proteins = Mostly β-sheet Acid-catalyzed membrane fusion = HA undergoes an acid-catalyzed conformational rearrangement, exposing a fusion peptide Viral entry mechanisms = Interaction of viral glycoprotein with cell receptor in the formation of fusion pore
Match the following with their features:
Class I fusion proteins = Perpendicular to membrane - spikes Class II fusion proteins = Form dimers Acid-catalyzed membrane fusion = Three states of influenza virus HA Virus entry = Fusion of viral and host cell membranes mediated by viral fusion proteins
Match the following with their corresponding viral fusion protein category:
Class I fusion proteins = Proteolytic cleavage activates the fusion protein for cleavage Class II fusion proteins = Fusion is regulated and must not occur in the wrong location
Match the following with their viral entry mechanism:
Reovirus = Entry involves uncoating at nuclear pore complex Adenovirus = Action of motor proteins aids in entry
Match the following with their description of virus entry:
Parvovirus = Binds to pore and causes disruption for entry Influenza virus = Genome small enough to enter nuclear pore
Match the following with their viral entry surface characteristics:
Plant Cell = Have rigid cell walls, require external trauma for viral entry Bacterial Cell = Have strong cell walls, some viruses exploit specialized structures for entry
Explore the process of attachment and entry in the infectious cycle of viruses, as well as how the viral genome enters the host cell. This lecture outlines the steps involved in viral replication and study facilitation.
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