12 Questions
What is the role of folate in DNA synthesis?
It is required for the synthesis of purine nucleotides and thymidylate.
What is the mechanism of action of methotrexate?
It inhibits the enzyme dihydrofolate reductase.
What is the main toxicity of methotrexate?
GIT epithelial damage and myelosuppression.
What is the mechanism of action of alkylating agents?
They bind covalently to DNA and cause abnormal base pairing.
What is the active form of cyclophosphamide?
Phosphoramide mustard
What is the adverse effect of acrolein?
Hemorrhagic cystitis
What is the mechanism of action of Vinca alkaloids in the cell cycle?
Binds to β-tubulin and prevents its ability to polymerize with α-tubulin into microtubules.
Which Vinca alkaloid is metabolized in the liver by CYP450 3A4 and has a half-life of 5 minutes, 2 hours, and 85 hours?
Vincristine
What is the primary route of excretion for vincristine sulfate?
Feces
Which of the following adverse effects is more common in vinblastine compared to vincristine?
Leukopenia
What is the protein-bound percentage of vinblastine in the blood?
98-99%
Which of the following cancers is NOT commonly treated with vincristine?
Colorectal cancer
Learn about the vinca alkaloids, including vincristine, vinblastine, vindesine, and vinrosidine, derived from the periwinkle plant. Understand their mechanism of action, effects on cell division, and toxicity. This quiz covers the key aspects of these medications.
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