14 Questions
Which protein is targeted by autoantibodies in Pemphigus Vulgaris?
Desmoglein 1
What is the characteristic feature of Pemphigus Erythematosus compared to other types of pemphigus?
Resembles lupus malar rash
Which disorder is characterized by intraepidermal vesicles associated with acantholysis?
Pemphigus
What is the main pathological mechanism in Pemphigus?
IgG against desmoglein 1, 3
Which layer gets separated in a blister according to the text?
Stratum basale
Which disease is associated with autoantibodies against Desmoglein 1?
Pemphigus Foliaceus
What type of adhesion structures are desmosomes?
Strong intercellular adhesion structures
Which type of tumor is associated with Paraneoplastic Pemphigus?
Lymphoma
In Bullous Pemphigoid, the autoimmune disease is characterized by IgG reacting against which proteins?
BP230 (BPAG 1)
Which age group is primarily affected by Bullous Pemphigoid?
Older adults
Epidermolysis Bullosa involves defects in which network at the dermal/epidermal junction?
Cytokeratin
Which type of Epidermolysis Bullosa variant is the most common?
Simplex
Which gene mutation is associated with Dystrophic Epidermolysis Bullosa?
Collagen VII
Porphyria results from a disturbance in the metabolism of which substance?
Porphyrins
Test your knowledge on vesiculobullous disorders that affect the skin and mucous membranes, including blisters, vesicles, and histologic features for diagnosis. Explore the different causes of blisters and the level of plane of separation in these disorders.
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