Erythema Multiforme and Autoimmune Vesiculobullous Diseases
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Questions and Answers

What is the primary characteristic that distinguishes Erythema Multiforme Major from Erythema Multiforme Minor?

  • Presence of oral lesions
  • Involvement of two or more mucosal sites (correct)
  • Widespread skin lesions
  • All of the above

    • What is the treatment of choice for Erythema Multiforme?

  • Topical corticosteroids
  • Antiviral medication
  • Systemic corticosteroids (correct)
  • Antibiotics

    • What is the diagnostic approach for autoimmune vesiculobullous diseases?

  • Clinical features only
  • Immunologic findings only
  • Clinical features and histologic findings
  • Clinical features, histologic findings, and immunologic findings (correct)

    • What is the characteristic feature of Ulcerative conditions?

    <p>Solitary or multifocal small clusters</p> Signup and view all the answers

    Which of the following is NOT a type of Ulcerative condition?

    <p>Erythema Multiforme</p> Signup and view all the answers

    What is the purpose of Acyclovir in the treatment of Erythema Multiforme?

    <p>To prevent recurrences in herpes-induced lesions</p> Signup and view all the answers

    What is the diagnostic tool used in autoimmune vesiculobullous diseases?

    <p>All of the above</p> Signup and view all the answers

    What is the etiology of Pemphigus Vulgaris?

    <p>Immune-mediated</p> Signup and view all the answers

    What is the characteristic of Pemphigoid?

    <p>Subepithelial split</p> Signup and view all the answers

    What is Erythema Multiforme related to?

    <p>HSV</p> Signup and view all the answers

    What is the characteristic of Erosive Lichen Planus?

    <p>Ulcerative condition</p> Signup and view all the answers

    What is the difference between Pemphigus and Pemphigoid?

    <p>Level of skin split</p> Signup and view all the answers

    What is the common cause of Ulcerative and Vesiculobullous conditions?

    <p>Autoimmune response</p> Signup and view all the answers

    Erythema multiforme is a type of?

    <p>Dermatologic disease</p> Signup and view all the answers

    What is a complication of erosive lichen planus?

    <p>Oral squamous cell carcinoma</p> Signup and view all the answers

    Which of the following is a heritable disease?

    <p>Darier disease</p> Signup and view all the answers

    Which of the following is an ulcerative condition?

    <p>Erosive lichen planus</p> Signup and view all the answers

    What is the name of the disorder characterized by blistering of the skin due to abnormalities in the basement membrane zone?

    <p>Epidermolysis bullosa</p> Signup and view all the answers

    What is a characteristic feature of oral lesions in Erythema Multiforme?

    <p>Crusting of lip vermilion</p> Signup and view all the answers

    Which of the following conditions is associated with oral ulcers?

    <p>All of the above</p> Signup and view all the answers

    What is a characteristic feature of Erythema Multiforme lesions?

    <p>Target lesions</p> Signup and view all the answers

    What is a treatment approach for Mucous Membrane Pemphigoid?

    <p>Systemic corticosteroids plus immunosuppressive agents</p> Signup and view all the answers

    What is a characteristic feature of Erosive Lichen Planus?

    <p>Ulcers and erythema</p> Signup and view all the answers

    What is a histopathological feature of Lichen Planus?

    <p>Superficial band-like lymphocytic infiltrate</p> Signup and view all the answers

    What is a complication of Erythema Multiforme?

    <p>All of the above</p> Signup and view all the answers

    What is an alternative treatment for Mucous Membrane Pemphigoid?

    <p>All of the above</p> Signup and view all the answers

    What is a characteristic feature of Drug-induced Erythema Multiforme?

    <p>Oral ulcers</p> Signup and view all the answers

    What is a term used to describe Erosive Lichen Planus?

    <p>Desquamative Gingivitis</p> Signup and view all the answers

    Which of the following conditions is characterized by characteristic target lesions?

    <p>Erythema Multiforme</p> Signup and view all the answers

    What can be a differential diagnosis for Erosive Lichen Planus?

    <p>Both A and B</p> Signup and view all the answers

    What is associated with Mucous Membrane Pemphigoid?

    <p>Ophthalmologist referral</p> Signup and view all the answers

    Study Notes

    Erythema Multiforme

    • Clinical subtypes: Minor and Major
    • Major: widespread skin lesions, plus 2 or more mucosal sites involved (e.g., oral, ocular, genital)
    • Treatment:
      • Corticosteroids (systemic or topical)
      • Hydration
      • Topical anesthetic agents
      • Eliminate causative drugs
      • Acyclovir to prevent recurrences in herpes-induced lesions

    Autoimmune Vesiculobullous Diseases

    • Diagnosis based on:
      • Clinical features
      • Histologic findings
      • Immunologic findings (immunofluorescence, ELISA)
    • Examples:
      • Pemphigus
      • Pemphigoid
      • Erosive lichen planus

    Ulcerative and Vesiculobullous Conditions

    • Solitary or multifocal, small cluster
    • Acute or chronic
    • Examples:
      • Pemphigus
      • Pemphigoid
      • Erosive lichen planus

    Lichen Planus

    • Treatment:
      • Topical corticosteroids (1st line)
      • Alternatives: topical calcineurin inhibitors, steroid-sparing agents, biologics
    • Histopathology: superficial band-like lymphocytic infiltrate; basilar vacuolar change

    Etiology of Ulcerative and Vesiculobullous Conditions

    • Viral: HSV, VZV
    • Immune-mediated: Pemphigus, Pemphigoid, Darier-White disease, Erythema multiforme
    • Heritable: Darier disease, Epidermolysis bullosa

    Mucous Membrane Pemphigoid

    • Treatment:
      • Ophthalmologist referral
      • Topical corticosteroids
      • Systemic corticosteroids plus immunosuppressive agents (cyclophosphamide)
      • Alternatives: Dapsone, Tetracycline, Minocycline, Niacinamide

    Erosive Lichen Planus

    • More common than pemphigoid and pemphigus
    • Doesn't really cause blistering; presents with ulcers, erythema
    • Also known as "desquamative gingivitis" (DDx includes pemphigoid and pemphigus)

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    Description

    Quiz on Erythema Multiforme, its clinical subtypes, treatment options, and diagnosis of Autoimmune Vesiculobullous Diseases. Covers clinical features, histologic and immunologic findings.

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