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Questions and Answers
What is the primary characteristic that distinguishes Erythema Multiforme Major from Erythema Multiforme Minor?
What is the primary characteristic that distinguishes Erythema Multiforme Major from Erythema Multiforme Minor?
- Presence of oral lesions
- Involvement of two or more mucosal sites (correct)
- Widespread skin lesions
- All of the above
What is the treatment of choice for Erythema Multiforme?
What is the treatment of choice for Erythema Multiforme?
- Topical corticosteroids
- Antiviral medication
- Systemic corticosteroids (correct)
- Antibiotics
What is the diagnostic approach for autoimmune vesiculobullous diseases?
What is the diagnostic approach for autoimmune vesiculobullous diseases?
- Clinical features only
- Immunologic findings only
- Clinical features and histologic findings
- Clinical features, histologic findings, and immunologic findings (correct)
What is the characteristic feature of Ulcerative conditions?
What is the characteristic feature of Ulcerative conditions?
Which of the following is NOT a type of Ulcerative condition?
Which of the following is NOT a type of Ulcerative condition?
What is the purpose of Acyclovir in the treatment of Erythema Multiforme?
What is the purpose of Acyclovir in the treatment of Erythema Multiforme?
What is the diagnostic tool used in autoimmune vesiculobullous diseases?
What is the diagnostic tool used in autoimmune vesiculobullous diseases?
What is the etiology of Pemphigus Vulgaris?
What is the etiology of Pemphigus Vulgaris?
What is the characteristic of Pemphigoid?
What is the characteristic of Pemphigoid?
What is Erythema Multiforme related to?
What is Erythema Multiforme related to?
What is the characteristic of Erosive Lichen Planus?
What is the characteristic of Erosive Lichen Planus?
What is the difference between Pemphigus and Pemphigoid?
What is the difference between Pemphigus and Pemphigoid?
What is the common cause of Ulcerative and Vesiculobullous conditions?
What is the common cause of Ulcerative and Vesiculobullous conditions?
Erythema multiforme is a type of?
Erythema multiforme is a type of?
What is a complication of erosive lichen planus?
What is a complication of erosive lichen planus?
Which of the following is a heritable disease?
Which of the following is a heritable disease?
Which of the following is an ulcerative condition?
Which of the following is an ulcerative condition?
What is the name of the disorder characterized by blistering of the skin due to abnormalities in the basement membrane zone?
What is the name of the disorder characterized by blistering of the skin due to abnormalities in the basement membrane zone?
What is a characteristic feature of oral lesions in Erythema Multiforme?
What is a characteristic feature of oral lesions in Erythema Multiforme?
Which of the following conditions is associated with oral ulcers?
Which of the following conditions is associated with oral ulcers?
What is a characteristic feature of Erythema Multiforme lesions?
What is a characteristic feature of Erythema Multiforme lesions?
What is a treatment approach for Mucous Membrane Pemphigoid?
What is a treatment approach for Mucous Membrane Pemphigoid?
What is a characteristic feature of Erosive Lichen Planus?
What is a characteristic feature of Erosive Lichen Planus?
What is a histopathological feature of Lichen Planus?
What is a histopathological feature of Lichen Planus?
What is a complication of Erythema Multiforme?
What is a complication of Erythema Multiforme?
What is an alternative treatment for Mucous Membrane Pemphigoid?
What is an alternative treatment for Mucous Membrane Pemphigoid?
What is a characteristic feature of Drug-induced Erythema Multiforme?
What is a characteristic feature of Drug-induced Erythema Multiforme?
What is a term used to describe Erosive Lichen Planus?
What is a term used to describe Erosive Lichen Planus?
Which of the following conditions is characterized by characteristic target lesions?
Which of the following conditions is characterized by characteristic target lesions?
What can be a differential diagnosis for Erosive Lichen Planus?
What can be a differential diagnosis for Erosive Lichen Planus?
What is associated with Mucous Membrane Pemphigoid?
What is associated with Mucous Membrane Pemphigoid?
Study Notes
Erythema Multiforme
- Clinical subtypes: Minor and Major
- Major: widespread skin lesions, plus 2 or more mucosal sites involved (e.g., oral, ocular, genital)
- Treatment:
- Corticosteroids (systemic or topical)
- Hydration
- Topical anesthetic agents
- Eliminate causative drugs
- Acyclovir to prevent recurrences in herpes-induced lesions
Autoimmune Vesiculobullous Diseases
- Diagnosis based on:
- Clinical features
- Histologic findings
- Immunologic findings (immunofluorescence, ELISA)
- Examples:
- Pemphigus
- Pemphigoid
- Erosive lichen planus
Ulcerative and Vesiculobullous Conditions
- Solitary or multifocal, small cluster
- Acute or chronic
- Examples:
- Pemphigus
- Pemphigoid
- Erosive lichen planus
Lichen Planus
- Treatment:
- Topical corticosteroids (1st line)
- Alternatives: topical calcineurin inhibitors, steroid-sparing agents, biologics
- Histopathology: superficial band-like lymphocytic infiltrate; basilar vacuolar change
Etiology of Ulcerative and Vesiculobullous Conditions
- Viral: HSV, VZV
- Immune-mediated: Pemphigus, Pemphigoid, Darier-White disease, Erythema multiforme
- Heritable: Darier disease, Epidermolysis bullosa
Mucous Membrane Pemphigoid
- Treatment:
- Ophthalmologist referral
- Topical corticosteroids
- Systemic corticosteroids plus immunosuppressive agents (cyclophosphamide)
- Alternatives: Dapsone, Tetracycline, Minocycline, Niacinamide
Erosive Lichen Planus
- More common than pemphigoid and pemphigus
- Doesn't really cause blistering; presents with ulcers, erythema
- Also known as "desquamative gingivitis" (DDx includes pemphigoid and pemphigus)
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Description
Quiz on Erythema Multiforme, its clinical subtypes, treatment options, and diagnosis of Autoimmune Vesiculobullous Diseases. Covers clinical features, histologic and immunologic findings.
