Vemurafenib in Metastatic Melanoma - Mechanism and Resistance
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Vemurafenib in Metastatic Melanoma - Mechanism and Resistance

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Questions and Answers

What is the main role of PARP in DNA repair?

  • Stopping the cell from proliferating
  • Enabling repair of DNA damage caused by alkylating agents (correct)
  • Causing mutations in BRCA genes
  • Repairing double-stranded DNA breaks

    • How do PARP inhibitors work in cancer treatment?

  • By stopping cell proliferation
  • By inhibiting PARP from repairing DNA damage (correct)
  • By causing mutations in BRCA genes
  • By enhancing DNA repair mechanisms

    • What is the specific weakness in BRCA mutated tumor cells that PARP inhibitors target?

  • Inability to repair DNA damage (correct)
  • BRCA gene overexpression
  • Enhanced DNA repair
  • Increased cell proliferation

    • How do BRCA1 and BRCA2 genes contribute to cancer development?

    <p>By enhancing DNA repair mechanisms</p> Signup and view all the answers

    What happens if the BRCA system is mutated?

    <p>Cell death due to lack of repair</p> Signup and view all the answers

    Why is the use of PARP inhibitors significant in breast cancer treatment?

    <p>To target BRCA mutated tumor cells</p> Signup and view all the answers

    Which type of DNA breaks are associated with BRCA gene function?

    <p>Double-stranded DNA breaks</p> Signup and view all the answers

    In the context of mutations, what effect do KRAS mutations have on metastatic colorectal cancer (mCRC)?

    <p><strong>Lead</strong> to resistance to targeted therapies</p> Signup and view all the answers

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