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Questions and Answers
What is the main role of PARP in DNA repair?
What is the main role of PARP in DNA repair?
- Stopping the cell from proliferating
- Enabling repair of DNA damage caused by alkylating agents (correct)
- Causing mutations in BRCA genes
- Repairing double-stranded DNA breaks
How do PARP inhibitors work in cancer treatment?
How do PARP inhibitors work in cancer treatment?
- By stopping cell proliferation
- By inhibiting PARP from repairing DNA damage (correct)
- By causing mutations in BRCA genes
- By enhancing DNA repair mechanisms
What is the specific weakness in BRCA mutated tumor cells that PARP inhibitors target?
What is the specific weakness in BRCA mutated tumor cells that PARP inhibitors target?
- Inability to repair DNA damage (correct)
- BRCA gene overexpression
- Enhanced DNA repair
- Increased cell proliferation
How do BRCA1 and BRCA2 genes contribute to cancer development?
How do BRCA1 and BRCA2 genes contribute to cancer development?
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What happens if the BRCA system is mutated?
What happens if the BRCA system is mutated?
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Why is the use of PARP inhibitors significant in breast cancer treatment?
Why is the use of PARP inhibitors significant in breast cancer treatment?
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Which type of DNA breaks are associated with BRCA gene function?
Which type of DNA breaks are associated with BRCA gene function?
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In the context of mutations, what effect do KRAS mutations have on metastatic colorectal cancer (mCRC)?
In the context of mutations, what effect do KRAS mutations have on metastatic colorectal cancer (mCRC)?
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