8 Questions
What is the main role of PARP in DNA repair?
Enabling repair of DNA damage caused by alkylating agents
How do PARP inhibitors work in cancer treatment?
By inhibiting PARP from repairing DNA damage
What is the specific weakness in BRCA mutated tumor cells that PARP inhibitors target?
Inability to repair DNA damage
How do BRCA1 and BRCA2 genes contribute to cancer development?
By enhancing DNA repair mechanisms
What happens if the BRCA system is mutated?
Cell death due to lack of repair
Why is the use of PARP inhibitors significant in breast cancer treatment?
To target BRCA mutated tumor cells
Which type of DNA breaks are associated with BRCA gene function?
Double-stranded DNA breaks
In the context of mutations, what effect do KRAS mutations have on metastatic colorectal cancer (mCRC)?
Lead to resistance to targeted therapies
Explore the mechanism of action of Vemurafenib in inhibiting BRAFV600E kinase, leading to the blockade of cell proliferation. Learn about the efficacy of BRAF inhibition in treating metastatic melanoma, the development of resistance over time, and the combination therapy with MEK inhibitors.
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