Vaccination: History and Global Impact
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Questions and Answers

What is the primary reason for deferring the destruction of live variola virus stocks?

  • To ensure the virus remains available for research
  • To prevent unauthorized access to smallpox
  • To reflect on the best options for global public health (correct)
  • To review the benefits of the variola virus research programme
  • What percentage of the smallpox genome can any institution legally possess according to WHO recommendations?

  • 10%
  • 5%
  • 50%
  • 20% (correct)
  • What is one of the severe complications that can arise from measles infections in children?

  • Acute respiratory distress syndrome
  • Chronic kidney disease
  • Rheumatoid arthritis
  • Acute encephalitis (correct)
  • In healthy children, what is the estimated death rate from complications due to measles?

    <p>1 to 2 in 1000 (D)</p> Signup and view all the answers

    What is the death rate from measles for immunocompromised individuals?

    <p>30% (A)</p> Signup and view all the answers

    Which of the following countries is not currently polio-endemic?

    <p>India (A)</p> Signup and view all the answers

    What is the main consequence of poliomyelitis infection?

    <p>Nerve injury leading to paralysis (A)</p> Signup and view all the answers

    Which of the following best describes measles?

    <p>A highly contagious viral infection (D)</p> Signup and view all the answers

    What percentage of the world population has received at least one dose of the COVID-19 vaccine?

    <p>70.6% (C)</p> Signup and view all the answers

    What was the significance of Edward Jenner's work in relation to infectious diseases?

    <p>He was the first to control disease through vaccination. (C)</p> Signup and view all the answers

    What is the fatality rate of smallpox as mentioned in the content?

    <p>20 to 60% (D)</p> Signup and view all the answers

    How did Jenner test his hypothesis about vaccination?

    <p>By injecting cowpox material into a child. (B)</p> Signup and view all the answers

    What ultimately happened to smallpox as a result of vaccination?

    <p>It was eradicated globally. (D)</p> Signup and view all the answers

    What was the boundary concern regarding smallpox even after its eradication?

    <p>Frozen samples still existing in laboratories. (B)</p> Signup and view all the answers

    Which of the following accurately reflects the historical context of smallpox vaccination?

    <p>Cowpox immunity was linked to smallpox immunity. (B)</p> Signup and view all the answers

    What global statistic about COVID-19 vaccinations is highlighted?

    <p>13.57 billion doses have been administered. (D)</p> Signup and view all the answers

    Why are polio vaccines still administered?

    <p>International travel increases the risk of outbreaks. (A)</p> Signup and view all the answers

    What defines herd immunity?

    <p>Majority of the population is immune to a specific pathogen. (B)</p> Signup and view all the answers

    Which of the following features impact vaccine effectiveness?

    <p>Pathogens establishing latency in hosts. (A), High antigenic variation in pathogens. (B), Pathogens interfering with the host immune response. (D)</p> Signup and view all the answers

    What is a reason for using passive immunity?

    <p>Immediate need for protection against complications. (A)</p> Signup and view all the answers

    What characterizes attenuated vaccines?

    <p>They provoke an immune response without causing the disease. (C)</p> Signup and view all the answers

    How are most flu vaccines produced?

    <p>Rooting in eggs for both inactivated and attenuated types. (B)</p> Signup and view all the answers

    What is the main difference between killed and attenuated viruses in vaccines?

    <p>Attenuated viruses are alive but non-pathogenic. (A)</p> Signup and view all the answers

    Which of the following best describes the issue with killed viral vaccines?

    <p>Boosters are often required for effective immunity. (C)</p> Signup and view all the answers

    Which Covid-19 vaccine is no longer in use?

    <p>Johnson and Johnson (A)</p> Signup and view all the answers

    What is a key limitation of killed viral vaccines?

    <p>They often need multiple doses for effective immunity. (C)</p> Signup and view all the answers

    What type of vaccine is primarily used in the flu shot?

    <p>Inactivated (killed) virus vaccines (A)</p> Signup and view all the answers

    Why must the flu vaccine be reformulated each year?

    <p>To reflect current strains circulating in the population (A)</p> Signup and view all the answers

    Which of the following strains was included in the 2021/22 flu vaccine?

    <p>B/Washington/02/2019 (A)</p> Signup and view all the answers

    What is the general outcome of vaccination in an individual?

    <p>Generation of an antibody response (A)</p> Signup and view all the answers

    How long did it take to develop the rotavirus vaccine?

    <p>30 years (D)</p> Signup and view all the answers

    What misconception about vaccines has been thoroughly debunked?

    <p>Vaccination can lead to autism (C)</p> Signup and view all the answers

    What was the nature of Wakefield's study linking MMR vaccine to autism?

    <p>Fraudulent with selective sampling (B)</p> Signup and view all the answers

    What happens when vaccination rates drop in the population?

    <p>Increase in infectious disease incidence (A)</p> Signup and view all the answers

    What type of virus is Rotarix?

    <p>Live attenuated human retrovirus (B)</p> Signup and view all the answers

    Which vaccine contains a mixture of nonpathogenic cattle rotoviruses?

    <p>RotaTeq (A)</p> Signup and view all the answers

    What was the first mRNA vaccine developed against?

    <p>Ebola virus (D)</p> Signup and view all the answers

    What is the primary goal of mRNA vaccines?

    <p>To produce neutralizing antibodies that recognize the spike protein (B)</p> Signup and view all the answers

    Which of the following vaccines is a protein subunit vaccine?

    <p>Novavax (D)</p> Signup and view all the answers

    What type of immune cells do mRNA vaccines aim to generate besides neutralizing antibodies?

    <p>CD8+ cytotoxic T-cells (B)</p> Signup and view all the answers

    Which of the following statements about mRNA technology is true?

    <p>It was used for developing a vaccine against SARS-CoV-2. (A)</p> Signup and view all the answers

    What common characteristic is shared by vaccines like Measles-mumps-rubella (MMR) and Hepatitis A?

    <p>They require two doses. (A)</p> Signup and view all the answers

    What is a potential outcome of receiving an mRNA vaccine?

    <p>Production of neutralizing antibodies and memory cells. (C)</p> Signup and view all the answers

    What is the significance of booster shots in vaccination?

    <p>They help to maintain or enhance immunity over time. (A)</p> Signup and view all the answers

    What is the primary function of adjuvants in vaccines?

    <p>To activate and enhance the immune response to antigens (C)</p> Signup and view all the answers

    Which type of immune response do adjuvants primarily activate?

    <p>Innate immune response (D)</p> Signup and view all the answers

    What is a characteristic of coronaviruses?

    <p>They are zoonotic, meaning they transmit between animals and humans (D)</p> Signup and view all the answers

    Which of the following coronaviruses was identified in 2003?

    <p>SARS-CoV (B)</p> Signup and view all the answers

    Why are vaccines against chronic infections less common?

    <p>Most effective vaccines target acute infections (D)</p> Signup and view all the answers

    What role do complement proteins and macrophages play in the immune response?

    <p>They are the first defense against a viral attack (A)</p> Signup and view all the answers

    What signals indicate that the innate immune response is insufficient?

    <p>Production of interferon and host cell death (B)</p> Signup and view all the answers

    How do respiratory viruses typically enter host cells?

    <p>By attaching to membrane proteins and triggering endocytosis (C)</p> Signup and view all the answers

    Which of the following statements about RNA vaccines is true?

    <p>They utilize messenger RNA to instruct cells to produce a viral protein (B)</p> Signup and view all the answers

    What happens to cells infected by viruses?

    <p>They are killed and release new viruses (D)</p> Signup and view all the answers

    What primarily limits the size of a cell?

    <p>The effective diffusion distance for substances (C)</p> Signup and view all the answers

    What is a primary goal of synthetic biology?

    <p>To create novel life forms starting from existing organisms (D)</p> Signup and view all the answers

    Which principle suggests selecting the hypothesis with the fewest assumptions?

    <p>Occam's razor (D)</p> Signup and view all the answers

    What is one method used in the scientific method to refine hypotheses?

    <p>Data collection and interpretation (B)</p> Signup and view all the answers

    What does the limit on cell size affect about cellular function?

    <p>The efficiency of nutrient exchange (A)</p> Signup and view all the answers

    What is the primary structural and functional unit of all living organisms?

    <p>Cell (C)</p> Signup and view all the answers

    Who was the first person to observe microscopic 'animalcules' in pond water?

    <p>Anton Leewenhoek (C)</p> Signup and view all the answers

    What term did Robert Hooke use to describe the pores in cork when observed under a microscope?

    <p>Cells (A)</p> Signup and view all the answers

    Which statement best describes tissues in biological terms?

    <p>Cells that aggregate to form a specific function (A)</p> Signup and view all the answers

    When were significant advancements in microscopy made that led to the discovery of cells?

    <p>1865 (C)</p> Signup and view all the answers

    What does a fully differentiated structural and functional unit in an animal refer to?

    <p>Organ (D)</p> Signup and view all the answers

    What is essential for understanding terminology in cell biology?

    <p>Use of a glossary (D)</p> Signup and view all the answers

    What structure is responsible for producing energy in a cell?

    <p>Mitochondria (D)</p> Signup and view all the answers

    What term is used to refer to the ancient common ancestor of all living cells?

    <p>Last Universal Common Ancestor (LUCA) (C)</p> Signup and view all the answers

    What do both prokaryotic and eukaryotic cells share?

    <p>Plasma membrane and ribosomes (C)</p> Signup and view all the answers

    Which of the following organisms is commonly used as a model organism in biological research?

    <p>Drosophila (fruit fly) (D)</p> Signup and view all the answers

    In what unit are cells commonly measured?

    <p>Micrometers (C)</p> Signup and view all the answers

    What distinguishes eukaryotic cells from prokaryotic cells?

    <p>Presence of a membrane-bound nucleus (D)</p> Signup and view all the answers

    What fundamental principle regarding all living organisms is supported by modern biology?

    <p>All living organisms share a common ancestor (C)</p> Signup and view all the answers

    What does the phrase 'form reflects function' imply in cellular biology?

    <p>The shape and size of cells are adapted to their specific functions (A)</p> Signup and view all the answers

    What is a common characteristic of both prokaryotic and eukaryotic cells?

    <p>Identical genetic code (B)</p> Signup and view all the answers

    Which type of cell is generally smaller, prokaryotic or eukaryotic?

    <p>Prokaryotic cells (B)</p> Signup and view all the answers

    Which process or structure is common among all cells?

    <p>Ribosomes for protein synthesis (D)</p> Signup and view all the answers

    Who were the key figures in articulating the cell theory?

    <p>Matthias Schleiden, Theodor Schwann, Rudolf Virchow (D)</p> Signup and view all the answers

    What is the primary means through which cells reproduce?

    <p>Cell division (C)</p> Signup and view all the answers

    What do HeLa cells represent in cellular biology?

    <p>Cultured tumor cells (B)</p> Signup and view all the answers

    Which property of cells allows them to maintain their complexity and ordered state?

    <p>Self-regulation (A)</p> Signup and view all the answers

    How do cells acquire energy necessary for their functions?

    <p>By utilizing products of photosynthesis (A)</p> Signup and view all the answers

    Which of the following best defines the metabolic activities of a cell?

    <p>A sum of cellular chemical reactions (B)</p> Signup and view all the answers

    What is the main role of motor proteins in cells?

    <p>Facilitate mechanical movements (D)</p> Signup and view all the answers

    What triggers a cell's response to environmental stimuli?

    <p>Receptor interaction (D)</p> Signup and view all the answers

    What significant concept does the statement 'all cells in an organism contain identical copies of DNA' convey?

    <p>Genetic identity among all cells (A)</p> Signup and view all the answers

    In which process do cells ensure an equal partitioning of genetic material?

    <p>Mitosis (A)</p> Signup and view all the answers

    What contributes to genetic variation in organisms according to the content?

    <p>Mutations in genes (C)</p> Signup and view all the answers

    How do feedback circuits function in cells?

    <p>To return the cell to a stable state (D)</p> Signup and view all the answers

    Cells produce energy by converting glucose into which compound?

    <p>ATP (D)</p> Signup and view all the answers

    What distinguishes a theory from a hypothesis?

    <p>A theory is a hypothesis that has been extensively tested. (C)</p> Signup and view all the answers

    Which of the following is an example of a scientific law?

    <p>Law of thermodynamics (D)</p> Signup and view all the answers

    What is one fundamental difference between prokaryotes and eukaryotes?

    <p>Eukaryotes have complex cellular structures. (B)</p> Signup and view all the answers

    What limits cell size in living organisms?

    <p>Surface area to volume ratio. (A)</p> Signup and view all the answers

    Which statement best characterizes a hypothesis?

    <p>It is a testable explanation consistent with most data. (D)</p> Signup and view all the answers

    What is the primary role of a cell?

    <p>To produce energy and build necessary substances for life (C)</p> Signup and view all the answers

    Who was responsible for the invention of the microscope that led to the discovery of cells?

    <p>Robert Hooke (D)</p> Signup and view all the answers

    What term did Hooke use to describe the structures he observed in cork?

    <p>Cells (D)</p> Signup and view all the answers

    What is an organ defined as in the context of cell biology?

    <p>A collection of tissues that perform a specific function (C)</p> Signup and view all the answers

    What did Anton Leewenhoek contribute to the field of cell biology?

    <p>First observation of microscopic 'animalcules' (C)</p> Signup and view all the answers

    How should students utilize the glossary provided in their resources?

    <p>Always be clear on the meaning of words (B)</p> Signup and view all the answers

    What defines tissues in the context of cellular organization?

    <p>Cells that aggregate to form a specific function (D)</p> Signup and view all the answers

    What was Hooke's observation regarding cork cells influenced by?

    <p>Living quarters of monks in a monastery (B)</p> Signup and view all the answers

    What limits the size of a cell?

    <p>The ability to exchange nutrients efficiently (C)</p> Signup and view all the answers

    What is the purpose of synthetic biology?

    <p>To create new living cells in the laboratory (D)</p> Signup and view all the answers

    Which of the following describes Occam's razor?

    <p>A rule to select the simplest explanation consistent with observations (A)</p> Signup and view all the answers

    How are scientific theories assessed according to the scientific method?

    <p>By collecting and interpreting data (B)</p> Signup and view all the answers

    What distinguishes a theory from a hypothesis in scientific terms?

    <p>A theory has been extensively tested and widely accepted. (B)</p> Signup and view all the answers

    What is one of the factors that can increase cell size beyond normal limits?

    <p>The efficiency of nutrient absorption (D)</p> Signup and view all the answers

    Which of the following best characterizes a scientific law?

    <p>It is a statement of fact confirmed by lengthy testing. (A)</p> Signup and view all the answers

    What are the fundamental differences between prokaryotes and eukaryotes?

    <p>Eukaryotes have a defined nucleus and complex organelles. (B)</p> Signup and view all the answers

    What limits cell size in biological entities?

    <p>The need for efficient transport of materials in and out of the cell. (B)</p> Signup and view all the answers

    Which of the following statements is the best definition of a hypothesis?

    <p>A speculative statement that has not been tested. (D)</p> Signup and view all the answers

    Which statement accurately reflects a characteristic shared by prokaryotic and eukaryotic cells?

    <p>They share a common genetic code. (B)</p> Signup and view all the answers

    What is the significance of LUCA in the study of cellular evolution?

    <p>LUCA represents a common ancestor for all living organisms. (C)</p> Signup and view all the answers

    Which type of cells are generally smaller and simpler in structure?

    <p>Prokaryotic cells (D)</p> Signup and view all the answers

    Which of the following organisms is NOT classified as a eukaryotic model organism?

    <p>Escherichia coli (bacterium) (A)</p> Signup and view all the answers

    What do cells share that indicates their common ancestry?

    <p>Identical genetic language (D)</p> Signup and view all the answers

    What does the concept 'form reflects function' imply in cellular biology?

    <p>Cell structure and function are interconnected. (C)</p> Signup and view all the answers

    How can cells be measured commonly?

    <p>In units of micrometers and nanometers (B)</p> Signup and view all the answers

    What distinguishes prokaryotic cells from eukaryotic cells?

    <p>Prokaryotic cells lack defined organelles. (C)</p> Signup and view all the answers

    Which of the following features do all cells share?

    <p>Presence of a plasma membrane (B)</p> Signup and view all the answers

    Which factor contributes to the classification of organisms as model organisms in biological studies?

    <p>Ease of manipulation and rapid generation time (A)</p> Signup and view all the answers

    Who articulated the cell theory in the mid-1800s?

    <p>Matthias Schleiden, Theodor Schwann, and Rudolf Virchow (D)</p> Signup and view all the answers

    What property allows cells to reproduce?

    <p>Cell division (A)</p> Signup and view all the answers

    What is the sum total of chemical reactions taking place in a cell known as?

    <p>Metabolism (C)</p> Signup and view all the answers

    Which process do cells utilize to acquire energy from glucose?

    <p>Cell respiration (D)</p> Signup and view all the answers

    Which of the following statements is true about genetic information in cells?

    <p>All cells contain identical DNA but may differentiate during development. (B)</p> Signup and view all the answers

    What characteristic allows cells to adapt to their environments and respond to stimuli?

    <p>Self-regulation (B)</p> Signup and view all the answers

    What role do motor proteins play in cells?

    <p>Enabling mechanical activities (B)</p> Signup and view all the answers

    What is one essential function of enzymes in cellular processes?

    <p>To increase the rate of chemical reactions (B)</p> Signup and view all the answers

    Why are HeLa cells significant in biological research?

    <p>They were the first tumor cells isolated from a patient. (D)</p> Signup and view all the answers

    How do most cells respond to environmental stimuli?

    <p>Through receptor interactions (D)</p> Signup and view all the answers

    Which of the following best describes the cellular process of division?

    <p>Genetic material is duplicated before division. (A)</p> Signup and view all the answers

    Which of the following best describes the complexity of cells?

    <p>Cells are highly complex and organized. (D)</p> Signup and view all the answers

    What defines a self-regulating cell?

    <p>Cells can maintain stable internal conditions. (A)</p> Signup and view all the answers

    How do cells acquire energy for functioning?

    <p>By breaking down various biochemical compounds (C)</p> Signup and view all the answers

    What structure is considered the basic microscopic unit of all living beings?

    <p>Cell (A)</p> Signup and view all the answers

    What did Robert Hooke discover when he first used the microscope?

    <p>Cork cells with pores (D)</p> Signup and view all the answers

    Which scientist is credited with the refinement of the microscope in the 17th century?

    <p>Anton Leewenhoek (C)</p> Signup and view all the answers

    What term describes a group of cells that aggregate to perform a specific function?

    <p>Tissue (D)</p> Signup and view all the answers

    What is the significance of Hooke's observations in relation to the study of cell biology?

    <p>They established the concept of cells as the basic unit of life. (C)</p> Signup and view all the answers

    In the early study of microscopy, what did Hooke refer to the small units he observed?

    <p>Cells (C)</p> Signup and view all the answers

    What type of organisms did Leewenhoek observe under the microscope?

    <p>Animalcules (C)</p> Signup and view all the answers

    What resource is recommended for understanding the terminology used in cell biology?

    <p>Glossary (D)</p> Signup and view all the answers

    What distinguishes a scientific law from a hypothesis?

    <p>A law is an established fact confirmed over a long period. (A)</p> Signup and view all the answers

    Which of the following statements is true about theories in science?

    <p>A theory is a hypothesis extensively tested and widely accepted. (C)</p> Signup and view all the answers

    What characteristic allows a hypothesis to be scientifically useful?

    <p>It must be testable through experiments or observations. (C)</p> Signup and view all the answers

    What is one of the fundamental differences between prokaryotes and eukaryotes?

    <p>Prokaryotes do not have membrane-bound organelles. (D)</p> Signup and view all the answers

    What is the term used for the ancient cell from which all living organisms evolved?

    <p>Last Universal Common Ancestor (C)</p> Signup and view all the answers

    Which statement accurately distinguishes prokaryotic cells from eukaryotic cells?

    <p>Prokaryotic cells lack membrane-bound organelles, unlike eukaryotic cells. (A)</p> Signup and view all the answers

    Which feature is shared by both prokaryotic and eukaryotic cells?

    <p>Identical genetic language (D)</p> Signup and view all the answers

    What is a fundamental principle regarding the relationship between cellular form and function?

    <p>Morphology reflects physiology. (C)</p> Signup and view all the answers

    Which of the following is NOT a type of eukaryotic model organism mentioned?

    <p>Escherichia coli (D)</p> Signup and view all the answers

    What unit is commonly used to measure cell sizes?

    <p>Micrometers (B)</p> Signup and view all the answers

    What characteristic is primarily associated with eukaryotic cells compared to prokaryotic cells?

    <p>Complex cellular structures (B)</p> Signup and view all the answers

    What role do ribosomes play in cells?

    <p>Synthesize proteins (C)</p> Signup and view all the answers

    Which of the following statements best describes the metabolic pathways in prokaryotic and eukaryotic cells?

    <p>They are identical due to their common ancestry. (C)</p> Signup and view all the answers

    Which of the following is a principle associated with the scientific method?

    <p>The simplest explanation is often the most likely correct (C)</p> Signup and view all the answers

    What is the main goal of synthetic biology?

    <p>To develop novel life forms from existing organisms (B)</p> Signup and view all the answers

    Which factor limits the volume of cytoplasm in a cell?

    <p>The genes available in the nucleus (C)</p> Signup and view all the answers

    What does the term 'tenuous' imply in the context of scientific facts?

    <p>Facts are subject to change and reinterpretation (B)</p> Signup and view all the answers

    Which statement accurately reflects a property of cells?

    <p>Cells are capable of self-regulation through feedback circuits. (C)</p> Signup and view all the answers

    What is a primary method through which cells reproduce?

    <p>By division where a 'mother' cell distributes its contents into two 'daughter' cells (D)</p> Signup and view all the answers

    Which structure is crucial for energy conversion in animal cells?

    <p>Mitochondria (A)</p> Signup and view all the answers

    What is the term for the sum total of all chemical reactions in a cell?

    <p>Metabolism (A)</p> Signup and view all the answers

    How do cells typically respond to external stimuli?

    <p>By altering their internal metabolism or behavior (D)</p> Signup and view all the answers

    What distinguishes HeLa cells in cell biology?

    <p>They are immortal cell lines derived from a cancer patient. (A)</p> Signup and view all the answers

    What is one function of motor proteins in cells?

    <p>To facilitate the transportation of materials or cell movement (D)</p> Signup and view all the answers

    What is a critical emerging property of cells discussed in the materials?

    <p>Cells evolve and adapt based on genetic variations. (B)</p> Signup and view all the answers

    Which property of cells allows them to be highly organized?

    <p>Presence of a structured genetic blueprint encoded in genes (D)</p> Signup and view all the answers

    How does photosynthesis contribute to cellular processes in animals?

    <p>It generates glucose that animals convert into energy. (D)</p> Signup and view all the answers

    What is the role of Enzymes in cellular chemical reactions?

    <p>They increase the rate of chemical reactions. (A)</p> Signup and view all the answers

    Which statement is NOT true about the genetic information in cells?

    <p>Cells utilize distinct genetic codes for specific functions. (A)</p> Signup and view all the answers

    What type of energy process depends on chloroplasts in certain cells?

    <p>Photosynthesis (D)</p> Signup and view all the answers

    Flashcards

    Vaccination

    A process that uses a vaccine to build immunity to a disease.

    Smallpox

    An infectious disease that was once very common and deadly but has been eradicated.

    Edward Jenner

    A doctor who pioneered the concept of vaccination against smallpox.

    Cowpox

    A disease similar to smallpox, used to create the first smallpox vaccine.

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    Vaccine effectiveness

    Measurable degree of protection against a disease provided by vaccination.

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    Smallpox eradication

    Complete elimination of smallpox from the world due to global vaccination efforts.

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    Global vaccination efforts

    International efforts to control and prevent diseases through widespread vaccination.

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    Vaccine samples

    Preserved samples of vaccines, predominantly of smallpox, in selected locations.

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    Smallpox containment risk

    An incident occurred that didn't compromise samples, but highlighted potential risks in containing the variola virus.

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    Variola virus research

    WHO research program on variola virus should benefit everyone, and virus destruction is postponed for five years.

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    Smallpox genome control

    No institution should hold over 20% of the smallpox genome.

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    Measles infection

    Highly contagious virus, impacting global health, causing pneumonia, encephalitis, and pregnancy complications.

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    Measles vaccination

    Critical for preventing measles-related death and brain damage, especially in children.

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    Polio infection

    Viral infection causing nerve injury and paralysis.

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    Polio endemic countries

    Pakistan, Afghanistan, and Nigeria are the only remaining countries with ongoing polio outbreaks.

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    Polio vaccination effectiveness

    Vaccination programs have dramatically reduced polio cases globally, but a few countries still have ongoing outbreaks.

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    Herd Immunity

    When a significant portion of a population is immune to a pathogen, making it difficult for the disease to spread.

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    Why do we still need Polio vaccines?

    Polio has not been eradicated, and with widespread international travel, there's a constant risk of outbreaks.

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    What is the leading cause of death globally?

    Infectious diseases remain the biggest threat to human life worldwide.

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    Features of Pathogens That Affect Vaccine Effectiveness

    The effectiveness of a vaccine depends on the pathogen's characteristics, like how much it changes, if it hides, and how it interacts with the immune system.

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    What makes measles vaccine unique?

    The measles vaccine is sensitive to heat, requiring careful storage and handling.

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    When is passive immunity used?

    Passive immunity is used when a person can't produce antibodies themselves, or when immediate protection is needed.

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    Types of COVID-19 Vaccines

    There are different types of COVID-19 vaccines, including mRNA (Pfizer, Moderna), viral vector (Johnson & Johnson), and protein subunit (Novavax).

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    Live Attenuated Vaccines

    These vaccines use a weakened version of the virus that can't cause the disease but stimulates the immune response.

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    How are most viral vaccines made?

    Most viral vaccines are made from killed or weakened versions of the virus.

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    What is an attenuated virus?

    An attenuated virus is a live virus that has been weakened so it can't cause disease, but can still trigger an immune response.

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    SARS-CoV-2 Replication in Eggs

    SARS-CoV-2, the virus responsible for COVID-19, does not replicate within eggs. This is different from some other viruses, like influenza, which are grown in eggs for vaccine production.

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    Current Flu Shot Composition

    The flu shot contains inactivated (killed) influenza viruses, which trigger an immune response without causing illness. It's typically a combination of three strains representing the most prevalent viruses.

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    Why the Flu Shot Changes Each Year?

    Flu viruses constantly evolve through genetic drift and shift, requiring annual adjustments to the vaccine formula to match circulating strains. This ensures the best protection for the upcoming flu season.

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    What Does the Flu Shot Do?

    The flu shot prompts your body to produce antibodies against specific flu strains. These antibodies help fight off infection if you encounter these strains.

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    Rotavirus Vaccine Development Time

    Creating a rotavirus vaccine took a lengthy 30 years of research and development. This illustrates the complexity and length of time needed to develop effective vaccines.

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    Rotavirus - A Serious Threat

    Rotavirus causes severe diarrhea, especially in children. It is a significant global burden, causing hundreds of thousands of deaths yearly.

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    Two Rotavirus Vaccines

    Two rotavirus vaccines are available: Rotarix, which uses a live, weakened human rotavirus, and RotaTeq, which contains a mix of five cattle rotaviruses that are safe for humans.

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    H1N1 Pandemic Vaccine Development

    The development of a vaccine against the 2009 H1N1 pandemic was rapid and involved many stages, including virus identification, vaccine production, and clinical trials.

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    Vaccinations and Measles Incidence

    When vaccination rates decline, the incidence of preventable diseases like measles increases. This highlights the importance of consistent vaccination programs.

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    Autism and Vaccination - Misconception

    There is no scientific link between autism and vaccination. This misconception was based on fraudulent research that has been repeatedly refuted.

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    mRNA Vaccines: Goal

    To produce neutralizing antibodies that recognize the spike protein and generate CD8+ cytotoxic T-cells, aiming to fight off the virus.

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    mRNA Vaccine Delivery

    Developed in the 70s, a safe method of delivering mRNA into cells was achieved after overcoming technical challenges.

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    First mRNA Vaccine

    Created against the Ebola virus, it lacked commercial potential despite being the first mRNA vaccine.

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    Commercial Potential of mRNA Vaccines

    Achieved with the emergence of SARS-CoV-2, paving the way for other applications, like cancer therapeutics.

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    RNA Vaccine: How it Works?

    The vaccine delivers mRNA that instructs the cells to produce the virus's spike protein, triggering an immune response.

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    Protein Subunit Vaccine: How it Works?

    The vaccine introduces a harmless version of the virus's spike protein, causing the immune system to produce antibodies.

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    Pfizer-BioNTech and Moderna Vaccines

    Both are RNA vaccines, while Novavax uses a protein subunit approach, all used for COVID-19 vaccination in Canada and the US.

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    Booster Shots

    They are administered to refresh the immune system's memory and maintain high levels of antibodies against the virus.

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    Adjuvants in Vaccines

    Substances added to vaccines to boost the immune response against the antigen, making the vaccine more effective.

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    How do Adjuvants Work?

    They activate the innate immune system, which is necessary to trigger the adaptive immune system and create a long-lasting immunity.

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    What is a Virus?

    A tiny infectious agent that consists of genetic material (RNA or DNA) enclosed in a protein coat. It needs a host cell to replicate.

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    Viral Proteins

    Viruses have three main types of proteins: replication, packaging and delivery, and host cell modification. These proteins help the virus replicate and spread.

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    Coronaviruses: Zoonotic

    Coronaviruses are zoonotic, meaning they can be transmitted from animals to humans and vice versa.

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    What are RNA Vaccines?

    RNA vaccines use a piece of genetic material (mRNA) that instructs the body's cells to produce a specific protein from the virus.

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    How do RNA Vaccines Work?

    The mRNA in the vaccine is taken up by cells, which use it to produce viral proteins. The immune system recognizes these proteins as foreign and develops immunity against the virus.

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    First Line of Defense Against Viruses

    The first line of defense against viruses is the innate immune system, involving complement proteins and macrophages.

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    When Does the Adaptive Immune System Kick In?

    The adaptive immune system is activated when the innate immune system is overwhelmed, involving natural killer cells, phagocytes, and interferon production.

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    How Do Respiratory Viruses Enter Cells?

    Respiratory viruses bind to normal membrane proteins on cells and trigger endocytosis, entering the cell.

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    Cell Size Limit

    The maximum size a cell can reach is limited by the amount of cytoplasm that can be supported by its genes and the efficiency of nutrient exchange and diffusion.

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    Acetabularia

    A green alga that defies typical cell size limitations, reaching lengths over 10 cm due to its unique cellular structure and adaptation.

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    Synthetic Biology

    A field of science focused on creating artificial life forms in a laboratory setting, often by manipulating existing organisms.

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    Scientific Method

    A systematic approach used to assess new information through hypothesis formulation, data collection, analysis, and conclusion based on the evidence.

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    Occam's Razor

    A principle stating that the simplest explanation that fits the observations is usually the most likely to be correct.

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    Cell

    The smallest, basic unit of life in all living organisms. It's responsible for producing energy and building the substances necessary for its own survival.

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    Tissue

    A group of similar cells that work together to perform a specific function.

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    Organ

    A fully developed, specialized unit in an animal composed of different tissues that work together to perform a complex function.

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    What is the role of Microscopy in discovering cells?

    Microscopes, invented by Robert Hooke and refined by Anton Leewenhoek, enabled scientists to observe the microscopic world, leading to the discovery and understanding of cells.

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    Hooke's Observation of Cells

    Robert Hooke observed the pores in cork, which he named 'cells' because they reminded him of the small rooms monks lived in.

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    Leeuwenhoek's Discovery

    Anton Leewenhoek was the first to examine pond water under a microscope, observing the teeming microscopic life he called 'animalcules'.

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    What are the fundamental units of all living organisms?

    Cells are the fundamental building blocks of all living organisms. They are responsible for all life processes.

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    What are the on-line resources available for Cell Biology study?

    The textbook offers on-line resources like glossaries, flashcards, quizzes, and practice questions to help students learn about cells.

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    LUCA

    The last universal common ancestor, a hypothetical single-celled organism from which all life on Earth evolved more than 3 billion years ago.

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    Prokaryotic Cells

    Cells that lack a nucleus and other membrane-bound organelles.

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    Eukaryotic Cells

    Cells with a nucleus and other membrane-bound organelles.

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    Common Features of All Cells

    All cells share basic features like a common genetic code, a plasma membrane, and ribosomes.

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    Model Organisms in Biology

    Simple organisms used in research due to their fast growth, large offspring, and ease of manipulation. Examples include bacteria, yeasts, fruit flies, nematode worms, and mice.

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    Micrometer (μm)

    A unit of measurement used for cells, equaling 10^-6 meters.

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    Nanometer (nm)

    A unit of measurement used for cell components, equaling 10^-9 meters.

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    Form Reflects Function

    The structure of a cell or organelle is directly related to its specific roles and activities.

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    Cellular Biochemistry

    The study of chemical processes occurring within cells, including metabolism and energy production.

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    Cell Biology

    The study of the structure, function, and behavior of cells, the fundamental units of life.

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    Hypothesis

    A proposed explanation for an observation that can be tested through experimentation. It's a statement that is consistent with most of the data, and may take the form of a model, which is an explanation that accounts for the data.

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    Theory

    A hypothesis that has been extensively tested and supported by multiple investigators using different approaches, it is widely accepted within the scientific community. It's a more comprehensive and robust explanation compared to a hypothesis.

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    What are the 3 tenants of cell theory?

    1. All living organisms are composed of one or more cells. 2. The cell is the basic unit of life. 3. All cells arise from pre-existing cells.
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    What limits cell size?

    Surface area to volume ratio. As a cell grows larger, its volume increases faster than its surface area, making it more difficult for the cell to exchange nutrients and waste with its environment.

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    Cell Theory

    A fundamental principle in biology that explains the basic structure and organization of living organisms. It states that all organisms are composed of one or more cells, the cell is the fundamental unit of life, and all cells arise from pre-existing cells.

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    HeLa Cells

    A line of human cells, originally derived from a cervical cancer patient, Henrietta Lacks, that are widely used in scientific research.

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    Cultured Cells

    Cells grown in a controlled environment outside of an organism, used for studying cell behavior, drug testing, and other research purposes.

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    What Makes Cells Complex?

    Cells are highly organized, possess a genetic program, replicate themselves, acquire and utilize energy, carry out chemical reactions, engage in mechanical activities, respond to stimuli, and regulate their internal environment.

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    Evolutionary Conservation

    Similar structure, composition, and metabolic features among cells of different species that have been preserved over evolutionary time.

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    Genes & Cellular Activity

    Genes, the units of heredity, store the information necessary for constructing cellular structures, carrying out cellular functions, and producing more cells.

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    Mutations and Evolution

    Changes in genetic information (mutations) contribute to variation among individuals, which provides the raw material for biological evolution.

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    How Cells Reproduce

    Cells reproduce by dividing, a process where the contents of a parent cell are equally distributed into two daughter cells, each containing a complete set of genetic information.

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    Photosynthesis & Energy

    Photosynthesis is the process by which plants convert light energy into chemical energy, which is used to fuel life on Earth.

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    Cellular Respiration

    The process by which cells break down glucose (sugar) to produce ATP, a molecule used for energy.

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    Enzymes & Metabolism

    Enzymes are proteins that catalyze (speed up) chemical reactions in cells, collectively known as metabolism.

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    Mechanical Activities in Cells

    Cells carry out a wide range of mechanical activities, from transporting materials to moving themselves, driven by changes in the shape of motor proteins.

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    Cells & Stimuli

    Cells have receptors that interact with external stimuli, like hormones and other molecules, allowing them to respond and adapt to changes in their environment.

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    Self-Regulation in Cells

    Cells maintain a stable internal environment through feedback circuits that regulate their composition and behavior.

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    Cells & Evolution

    Cells have evolved over millions of years, adapting to different environments and developing new features.

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    Microscope

    A tool that magnifies small objects, enabling the observation of cells and other microscopic structures.

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    Robert Hooke

    A scientist who first observed cells in cork using a microscope, naming them 'cells' because they reminded him of monk's cells in a monastery.

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    Anton Leewenhoek

    A scientist who refined the microscope and was the first to observe living 'animalcules' (microscopic organisms) in pond water.

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    What are the three tenets of cell theory?

    1. All living organisms are composed of one or more cells. 2. The cell is the basic unit of life. 3. All cells arise from pre-existing cells.
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    What are model organisms?

    Simple organisms used in research due to their rapid growth, large offspring, and ease of manipulation. Examples include bacteria, yeasts, fruit flies, nematode worms, and mice.

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    Matthias Schleiden

    A German botanist who contributed to the development of cell theory by recognizing that all plants are made up of cells.

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    Theodor Schwann

    A German physiologist who extended cell theory to animals, recognizing that all living things are made up of cells.

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    Rudolf Virchow

    A German physician who proposed the concept of 'omnis cellula e cellula,' meaning all cells arise from pre-existing cells.

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    What are the three main components of cell theory?

    1. All living things are made up of cells. 2. Cells are the basic unit of life. 3. All cells arise from pre-existing cells.
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    What are the basic properties of cells?

    Cells are complex and organized, possess a genetic program, replicate themselves, acquire and utilize energy, carry out chemical reactions, engage in mechanical activities, respond to stimuli, and regulate their internal environment.

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    Photosynthesis: Energy Source

    Photosynthesis is the process by which plants convert light energy into chemical energy, which is used to fuel life on Earth.

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    Cellular Respiration: Energy Conversion

    The process by which cells break down glucose (sugar) to produce ATP, a molecule used for energy.

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    Enzymes & Metabolism: Chemical Reactions

    Enzymes are proteins that catalyze (speed up) chemical reactions in cells, collectively known as metabolism.

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    Model Organisms

    Simple organisms used in research due to their fast growth, large offspring, and ease of manipulation.

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    What is Synthetic Biology?

    A scientific field focused on creating artificial life forms in a laboratory setting, often by manipulating existing organisms. It aims to design and build new biological parts, devices, and systems, with potential applications in medicine, industry, and the environment.

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    The Scientific Method

    A systematic approach used to investigate and understand the natural world. It involves formulating hypotheses, conducting experiments, analyzing data, and drawing conclusions. The goal is to test ideas and build a body of knowledge based on evidence.

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    What are the basic units of life?

    Cells are the fundamental building blocks of all living organisms, responsible for carrying out all essential life processes.

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    What is the role of microscopy in cell biology?

    Microscopes, invented by Robert Hooke and refined by Anton Leewenhoek, enabled scientists to observe the microscopic world, leading to the discovery and understanding of cells.

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    What did Robert Hooke observe?

    Robert Hooke observed the pores in cork, which he named 'cells' because they reminded him of the small rooms monks lived in.

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    What did Anton Leewenhoek discover?

    Anton Leewenhoek, using a refined microscope, was the first to observe living 'animalcules' (microscopic organisms) in pond water.

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    Cell size limitation

    The maximum size a cell can reach is limited by the amount of cytoplasm that can be supported by its genes and the efficiency of nutrient exchange and diffusion.

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    What is the scientific method?

    A systematic approach used to assess new information through hypothesis formulation, data collection, analysis, and conclusion based on the evidence.

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    Who articulated the Cell Theory?

    The Cell Theory was articulated in the mid-1800s by Matthias Schleiden, Theodor Schwann, and Rudolf Virchow.

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    Cell Division

    The process by which cells reproduce, where the contents of a parent cell are equally distributed into two daughter cells, each containing a complete set of genetic information.

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    What is a Gene?

    A unit of heredity, a segment of DNA that carries instructions for building a cellular structure or carrying out a specific function.

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    What is Metabolism?

    The sum total of all chemical reactions happening within a cell.

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    What is Photosynthesis?

    The process by which plants convert light energy into chemical energy, fueling life on Earth.

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    What is Cellular Respiration?

    The process by which cells break down glucose (sugar) to produce ATP, a molecule used for energy.

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    What are Enzymes?

    Proteins that catalyze (speed up) chemical reactions in cells.

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    What are Motor Proteins?

    Proteins responsible for cellular movement and transportation within cells.

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    What is Self-Regulation in Cells?

    Cells maintain a stable internal environment through feedback circuits that regulate their composition and behavior.

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    What is Evolutionary Conservation?

    Similar structure, composition, and metabolic features among cells of different species that have been preserved over evolutionary time.

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    What is LUCA?

    The Last Universal Common Ancestor, a hypothetical single-celled organism from which all life on Earth evolved.

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    Prokaryotes vs. Eukaryotes

    Prokaryotic cells lack a nucleus and other membrane-bound organelles, while eukaryotic cells have a nucleus and other organelles. Prokaryotes are generally smaller and simpler than eukaryotes.

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    What are HeLa Cells?

    A line of human cells, originally derived from a cervical cancer patient, Henrietta Lacks, that are widely used in scientific research.

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    What are Cultured Cells?

    Cells grown in a controlled environment outside of an organism, used for studying cell behavior, drug testing, and other research purposes.

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    Study Notes

    Vaccination

    •  Cartoon depicts anti-vaccine sentiments and misinformation
    •  Cartoon highlights the spread of misinformation regarding vaccines and encourages community vaccination

    Global Vaccine Situation

    •  775,251,779 total COVID-19 cases reported as of March 31, 2024
    •  7,043,660 total COVID-19 deaths reported as of March 31, 2024
    •  13.57 billion doses of COVID-19 vaccines administered globally
    •  70.6% of the world's population has received at least one dose of a COVID-19 vaccine
    •  32.7% of low-income countries have received at least one dose of a COVID-19 vaccine

    Smallpox Vaccination

    •  Smallpox was a deadly disease with a 20-60% fatality rate
    •  Survivors were often immune after contracting the disease
    •  Observations linked milkmaids contracting cowpox to immunity against smallpox
    •  In May 1796, Jenner used material from a cowpox lesion to inoculate an 8-year-old boy, who did not contract smallpox later
    •  Jenner's work was a first attempt to control an infectious disease

    Smallpox Eradication and Current Status

    •  Smallpox was officially eradicated after a three-year period (no cases)
    •  Smallpox vaccines are no longer administered
    •  Frozen smallpox samples exist in the US and Russia; controversy regarding their destruction
    •  A gas explosion at a Russian lab in 2019 involved smallpox samples, but no samples were compromised
    •  WHO recommended deferring live variola virus stock destruction by up to five years

    Measles Vaccination

    •  Measles is a highly contagious viral disease leading to pneumonia, encephalitis and pregnancy complications
    •  Measles is one of the leading vaccine-preventable causes of death globally
    •  Healthy children have a 1 in 1000 risk of contracting encephalitis after measles, often resulting in permanent brain damage
    •  Healthy children have a 1-2 in 1000 risk of death after measles from respiratory or neurological complications
    •  Immunocompromised individuals have a near 30% risk of death from measles.
    •  Measles is still a global concern.

    Polio Vaccination

    •  Poliomyelitis is a viral infection that can cause nerve damage and paralysis
    •  Currently, there are only three countries with ongoing polio epidemics: Pakistan, Afghanistan, and Nigeria
    •  Polio vaccines are still administered globally to prevent epidemic outbreaks due to high international travel volume

    Herd Immunity

    •  Herd immunity occurs when most of a population is immune to an infectious disease
    •  The spread of disease in a community with herd immunity is reduced
    •  This helps protect susceptible individuals

    Infectious Diseases

    •  Infectious diseases remain the leading cause of death globally
    •  This section lists several infectious diseases and the effective vaccines for each

    Effective Vaccines

    •  Effective vaccines must not cause illness themselves and offer sustained protection against disease
    •  Effective vaccines must elicit enduring immunity to pathogens
    •  Safe vaccines for use in humans must either be inactive (killed) or attenuated (weakened) forms of virus

    Flu Vaccine

    •  Most flu vaccines are grown in fertilized chicken eggs (~82%)
    •  Cell-based flu vaccines are emerging as an alternative
    •  Flu vaccines must be reformulated annually due to viral variations

    COVID-19 Vaccines

    •  Three different types of COVID-19 vaccines are currently used:  mRNA, protein subunit, and adenoviral vector vaccines
    •  COVID-19 vaccines involve mRNA technology and contain the instructions to produce the COVID-19 spike protein, which generate an immune response in humans

    Immune System Response to Viral Attack

    •  Initial defense against viral attack are complement proteins and macrophages
    •  Natural killer cells and additional phagocytes (neutrophils) are activated if response is insufficient
    •  Adaptive immune system is slower to respond to new viruses if innate immune system is overwhelmed.

    Viral Replication and Vaccination

    •  Most viral vaccines are made from killed or attenuated viruses to elicit an immune response
    •  Killed viruses are not capable of replicating
    •  Attenuated viruses are capable of replicating but lack pathogenicity in humans

    Additional Information

    •  Adjuvants are substances added to vaccines to strengthen the immune response
    •  A variety of vaccines are used for different purposes.

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