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Questions and Answers
What is one of the primary functions of the urinary system?
What is one of the primary functions of the urinary system?
Which structure is responsible for transporting urine from the kidneys to the bladder?
Which structure is responsible for transporting urine from the kidneys to the bladder?
What is the approximate weight range of a human kidney?
What is the approximate weight range of a human kidney?
Which of the following is not a function of the urinary system?
Which of the following is not a function of the urinary system?
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What best describes the anatomical position of the kidneys?
What best describes the anatomical position of the kidneys?
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What is the primary physiological response of myogenic regulation in the context of glomerular filtration rate (GFR)?
What is the primary physiological response of myogenic regulation in the context of glomerular filtration rate (GFR)?
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How does a decrease in blood pressure (BP) affect glomerular filtration rate (GFR)?
How does a decrease in blood pressure (BP) affect glomerular filtration rate (GFR)?
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What mechanism is involved in tubuloglomerular feedback?
What mechanism is involved in tubuloglomerular feedback?
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Which of the following best describes extrinsic controls of GFR?
Which of the following best describes extrinsic controls of GFR?
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What is the role of glomerular capillary pressure in regulating GFR?
What is the role of glomerular capillary pressure in regulating GFR?
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What is the glomerular filtration rate (GFR) in mL/min?
What is the glomerular filtration rate (GFR) in mL/min?
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Which structure represents a barrier that glomerular filtrate must cross to enter Bowman's capsule?
Which structure represents a barrier that glomerular filtrate must cross to enter Bowman's capsule?
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What pressure is primarily responsible for favoring filtration in the glomerulus?
What pressure is primarily responsible for favoring filtration in the glomerulus?
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Which of the following pressures opposes glomerular filtration?
Which of the following pressures opposes glomerular filtration?
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Which element is NOT a barrier that glomerular filtrate must pass through?
Which element is NOT a barrier that glomerular filtrate must pass through?
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What is the primary function of the renal arteries?
What is the primary function of the renal arteries?
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Which factor contributes to the high glomerular capillary hydrostatic pressure?
Which factor contributes to the high glomerular capillary hydrostatic pressure?
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What is the oncotic pressure of Bowman's capsule?
What is the oncotic pressure of Bowman's capsule?
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Which structure directly receives blood from the glomerulus?
Which structure directly receives blood from the glomerulus?
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How many barriers must glomerular filtrate cross to enter Bowman's capsule?
How many barriers must glomerular filtrate cross to enter Bowman's capsule?
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What percentage of cardiac output do the renal arteries receive at rest?
What percentage of cardiac output do the renal arteries receive at rest?
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During which process does fluid move from the glomerulus to Bowman's capsule?
During which process does fluid move from the glomerulus to Bowman's capsule?
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Which structure is part of the juxtaglomerular apparatus and plays a role in blood pressure regulation?
Which structure is part of the juxtaglomerular apparatus and plays a role in blood pressure regulation?
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What is the main role of peritubular capillaries in kidney function?
What is the main role of peritubular capillaries in kidney function?
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What is the pathway of blood flow from the renal artery to the renal vein?
What is the pathway of blood flow from the renal artery to the renal vein?
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Which of the following processes does NOT occur in the renal tubules?
Which of the following processes does NOT occur in the renal tubules?
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What is primarily responsible for detecting changes in blood pressure?
What is primarily responsible for detecting changes in blood pressure?
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Where does the majority of solute reabsorption occur in the nephron?
Where does the majority of solute reabsorption occur in the nephron?
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Which of the following best describes the role of renal sympathetic nervous activity in blood pressure regulation?
Which of the following best describes the role of renal sympathetic nervous activity in blood pressure regulation?
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The movement of substances from the renal tubules back into the bloodstream is known as what?
The movement of substances from the renal tubules back into the bloodstream is known as what?
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Which physiological concept explains the return of blood volume to normal after a hemorrhage?
Which physiological concept explains the return of blood volume to normal after a hemorrhage?
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Which structure acts as a barrier during the reabsorption process in the kidneys?
Which structure acts as a barrier during the reabsorption process in the kidneys?
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What effect does increased renal vascular resistance have on mean arterial pressure (MAP)?
What effect does increased renal vascular resistance have on mean arterial pressure (MAP)?
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What is the primary mechanism through which the body responds to decreased renal perfusion pressure?
What is the primary mechanism through which the body responds to decreased renal perfusion pressure?
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What happens when solute in the filtrate saturates the carrier proteins?
What happens when solute in the filtrate saturates the carrier proteins?
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What is the transport maximum for glucose reabsorption?
What is the transport maximum for glucose reabsorption?
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Which type of transport is primarily responsible for glucose reabsorption at the apical membrane?
Which type of transport is primarily responsible for glucose reabsorption at the apical membrane?
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What does the renal threshold refer to in terms of glucose?
What does the renal threshold refer to in terms of glucose?
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During passive solute reabsorption, which factor influences the direction of solute movement?
During passive solute reabsorption, which factor influences the direction of solute movement?
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What occurs when glucose in the plasma reaches a concentration of 300 mg/dL?
What occurs when glucose in the plasma reaches a concentration of 300 mg/dL?
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Which membrane transport mechanism is utilized by glucose at the basolateral membrane?
Which membrane transport mechanism is utilized by glucose at the basolateral membrane?
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What is the typical filtered load of glucose per minute at a plasma glucose concentration of 100 mg/dL?
What is the typical filtered load of glucose per minute at a plasma glucose concentration of 100 mg/dL?
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Flashcards
Functions of the Urinary System
Functions of the Urinary System
The urinary system regulates plasma ion balance, volume, osmolarity, and pH; removes waste products; secretes erythropoietin and renin; activates Vitamin D3; and performs gluconeogenesis.
Kidney Size and Shape
Kidney Size and Shape
The kidneys are bean-shaped, roughly the size of a fist, and weigh approximately 115-170 grams.
Kidney Location
Kidney Location
Paired kidneys are located behind the abdominal lining (retroperitoneal).
Urinary System Pathway
Urinary System Pathway
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Kidney Structures
Kidney Structures
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Glomerular filtration
Glomerular filtration
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Reabsorption
Reabsorption
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Secretion
Secretion
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Excretion
Excretion
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What is the function of the afferent arteriole?
What is the function of the afferent arteriole?
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What is the function of the efferent arteriole?
What is the function of the efferent arteriole?
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What is the function of the peritubular capillaries?
What is the function of the peritubular capillaries?
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What is the function of the juxtaglomerular apparatus?
What is the function of the juxtaglomerular apparatus?
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Glomerular Filtration Rate (GFR)
Glomerular Filtration Rate (GFR)
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Myogenic Regulation of GFR
Myogenic Regulation of GFR
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Tubuloglomerular Feedback (TGF)
Tubuloglomerular Feedback (TGF)
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What happens to GFR with decreased blood pressure?
What happens to GFR with decreased blood pressure?
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Extrinsic Control of GFR
Extrinsic Control of GFR
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Barriers to Glomerular Filtration
Barriers to Glomerular Filtration
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What are Starling Forces?
What are Starling Forces?
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Starling Forces Favoring Filtration
Starling Forces Favoring Filtration
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Starling Forces Opposing Filtration
Starling Forces Opposing Filtration
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Hydrostatic Pressure
Hydrostatic Pressure
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Oncotic Pressure
Oncotic Pressure
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What is Reabsorption?
What is Reabsorption?
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Where does most Reabsorption occur?
Where does most Reabsorption occur?
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What is Solute Reabsorption?
What is Solute Reabsorption?
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Where does some Solute Reabsorption take place?
Where does some Solute Reabsorption take place?
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What are the barriers to Reabsorption?
What are the barriers to Reabsorption?
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What happens when blood volume decreases?
What happens when blood volume decreases?
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How does the body increase blood pressure?
How does the body increase blood pressure?
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What is negative feedback in blood pressure regulation?
What is negative feedback in blood pressure regulation?
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Peritubular space
Peritubular space
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Lumen
Lumen
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Apical membrane
Apical membrane
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Basolateral membrane
Basolateral membrane
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Transport maximum
Transport maximum
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Renal threshold
Renal threshold
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What is the role of carrier proteins in glucose reabsorption?
What is the role of carrier proteins in glucose reabsorption?
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Study Notes
The Urinary System
- The urinary system regulates plasma ionic composition, volume, osmolarity, and pH.
- It removes metabolic wastes and foreign substances from the plasma.
- Other functions include secreting erythropoietin and renin, activating vitamin D3 to calcitriol, and gluconeogenesis.
Anatomy of the Urinary System
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Structures of the urinary system:
- Kidneys: form urine
- Ureters: transport urine from kidneys to bladder
- Bladder: stores urine
- Urethra: excretes urine from bladder to outside of the body
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Macroscopic anatomy of the kidneys:
- Paired, bean-shaped organs
- Approximate size of a fist (115-170 grams)
- Retroperitoneal
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Microscopic anatomy of the kidneys:
- The nephron is the functional unit.
- Renal corpuscle includes the glomerulus (a capillary network for filtration) and Bowman's capsule (receives filtrate).
- Renal tubules include the proximal tubule, proximal convoluted tubule, proximal straight tubule, loop of Henle (descending and ascending limbs, thin and thick), distal convoluted tubule, connecting tubule, and collecting duct.
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Blood supply to the kidneys:
- Renal arteries enter the kidney at the hilus, receiving 20% of cardiac output at rest.
- Account for less than 1% of body weight but for 16% of ATP usage by the body.
- Function to filter blood
- Renal veins exit at hilus
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Cortical versus juxtamedullary nephrons:
- Cortical nephrons: have short loops of Henle, most numerous (80-85%).
- Juxtamedullary nephrons: have long loops of Henle extending into the medulla, responsible for the medullary osmotic gradient.
Basic Renal Exchange Processes
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Glomerular Filtration:
- Movement of protein-free plasma from glomerulus to Bowman's capsule.
- Glomerular filtration rate (GFR) is 125 mL/min or 180 L/day.
- The filtrate must cross three barriers: capillary endothelial layer, surrounding epithelial layer (podocytes), and basement membrane.
- Starling forces govern glomerular filtration: glomerular capillary hydrostatic pressure (favors filtration), Bowman's capsule hydrostatic pressure (opposes filtration), glomerular oncotic pressure (opposes filtration), Bowman's capsule oncotic pressure (favors filtration).
- The net filtration pressure is calculated as the sum of the forces favoring filtration minus the sum of the forces opposing filtration. This results in a net filtration pressure of 16 mm Hg.
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Reabsorption: Movement from tubules into peritubular capillaries (returned to blood). Mostly occurs in the proximal tubules and is not usually regulated.
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Secretion: Movement from peritubular capillaries into tubules. Barriers and transport mechanisms are similar to reabsorption, but in the opposite direction. Examples include substances like potassium, hydrogen ions, choline, creatinine, and penicillin.
Regulation of GFR
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Intrinsic regulation:
- Myogenic regulation: smooth muscle in the afferent arteriole constricts in response to stretch.
- Tubuloglomerular feedback: macula densa cells sense fluid flow and secrete paracrine factors to adjust afferent arteriole diameter.
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Extrinsic regulation:
- Decreases in blood pressure can decrease GFR, directly by decreasing filtration pressure and indirectly through extrinsic controls.
Transport Maximum
- The rate of transport when carriers are saturated. Renal Threshold: the plasma concentration where a solute's transport maximum is exceeded, causing some solute to be excreted in the urine.
- Example of transport maximum: handling of glucose
- Theoretical threshold: 300 mg/dL filtered load = 225 mg/min for glucose.
- Actual threshold: approximately 160 - 180 mg/dL.
Regional Specialization of the Renal Tubules
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Nonregulated reabsorption in proximal tubules. Proximal tubule is the mass reabsorber of 70% sodium and 100% glucose, but the rate is not dependent on external regulation or feedback loops.
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Regulated reabsorption and secretion in distal tubules and collecting ducts.
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Water conservation in the loop of Henle. The loop of Henle creates conditions to concentrate urine, minimizing water loss.
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Description
Explore the intricacies of the urinary system, including its anatomy and essential functions. This quiz covers the roles of the kidneys, ureters, bladder, and urethra, as well as the microscopic structures essential for urine formation. Test your knowledge on these crucial physiological processes.