Lec 12- Upper Respiratory Tract Infections

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Questions and Answers

What is the typical duration of symptoms in acute rhinosinusitis?

  • More than 12 weeks
  • Less than 4 weeks (correct)
  • Between 4 and 12 weeks
  • More than 6 months

What percentage of adults in the US are affected by sinusitis annually?

  • 1 in 20
  • 1 in 50
  • 1 in 7 (correct)
  • 1 in 3

Purulent nasal discharge is classified as what type of symptom relating to rhinosinusitis?

  • A rare symptom
  • A major symptom (correct)
  • An irrelevant symptom
  • A minor symptom

Which of the following is a common viral cause of rhinosinusitis?

<p>Rhinovirus (D)</p> Signup and view all the answers

For adults, what is the typical treatment duration for bacterial rhinosinusitis with amoxicillin-clavulanate?

<p>5-7 days (B)</p> Signup and view all the answers

What adjunctive therapy is recommended for rhinosinusitis?

<p>Intranasal saline irrigation (D)</p> Signup and view all the answers

A patient's symptoms worsen after 48-72 hours of treatment, what should be considered?

<p>Switch to an alternate antibiotic (C)</p> Signup and view all the answers

What is the primary cause of pharyngitis?

<p>Viral infection (A)</p> Signup and view all the answers

In adults, approximately what fraction of sore throats are caused by Group A Streptococcus (GAS)?

<p>1/10 (D)</p> Signup and view all the answers

What causes Group A strep pharyngitis?

<p>Streptococcus pyogenes (B)</p> Signup and view all the answers

Which symptom is specifically associated with viral pharyngitis?

<p>Hoarseness (A)</p> Signup and view all the answers

What is a common clinical finding in GAS pharyngitis?

<p>Tonsillopharyngeal erythema (A)</p> Signup and view all the answers

What is the recommended course of action following a negative rapid antigen detection test (RADT) for pharyngitis when viral features are absent?

<p>Follow-up culture (C)</p> Signup and view all the answers

How is GAS pharyngitis typically transmitted?

<p>Through respiratory droplets (C)</p> Signup and view all the answers

What is the recommended duration of treatment for GAS pharyngitis with oral penicillin?

<p>10 days (C)</p> Signup and view all the answers

What medication is appropriate to avoid as adjunctive therapy in children with pharyngitis?

<p>Aspirin (C)</p> Signup and view all the answers

Which of the following is a potential delayed sequela of GAS infections?

<p>Rheumatic fever (D)</p> Signup and view all the answers

What is the most common age for rheumatic fever?

<p>5-15 years old (C)</p> Signup and view all the answers

What is the primary goal of therapy in treating GAS pharyngitis?

<p>Prevent spread of infection to others (C)</p> Signup and view all the answers

According to clinical practice guidelines, what should be done in management of Group A Streptococcal Pharyngitis?

<p>Treat with antibiotics such as Penicillin (D)</p> Signup and view all the answers

What is acute bronchitis characterized by?

<p>Inflammation in the airways of the lungs (D)</p> Signup and view all the answers

What is the duration of cough for acute bronchitis?

<p>Up to 3 weeks (D)</p> Signup and view all the answers

What is the most common cause of acute bronchitis?

<p>Viruses (D)</p> Signup and view all the answers

What is one of the symptoms of acute bronchitis

<p>Chest Soreness (A)</p> Signup and view all the answers

Which of the following symptoms are suggestive of pneumonia rather than bronchitis?

<p>Tachypnea (C)</p> Signup and view all the answers

What kind of care would you recommend for acute bronchitis?

<p>Supportive care (C)</p> Signup and view all the answers

What is one of the components of symptomatic management for acute bronchitis?

<p>Humidifier (A)</p> Signup and view all the answers

What should you recommend against to a patient with acute bronchitis

<p>The use of antibiotics (D)</p> Signup and view all the answers

Which of the following is a risk associated with the overprescribing of antibiotics?

<p>Increased antimicrobial resistance (B)</p> Signup and view all the answers

What strategies may reduce the reduced antibiotic use?

<p>Address patient concerns and make delayed prescription strategies. (D)</p> Signup and view all the answers

What is something you can say to your patients to help prevent them from thinking they need antibiotics to treat a viral infection or chest cold?

<p>Describe the infection as a viral illness or chest cold. (D)</p> Signup and view all the answers

What is the initial step in differentiating between bacterial and viral etiologies of upper respiratory tract infections (URTIs)?

<p>Evaluating clinical signs and symptoms. (A)</p> Signup and view all the answers

Which clinical manifestation is more indicative of bacterial sinusitis rather than viral sinusitis?

<p>Severe facial pain lasting 3-4 days (A)</p> Signup and view all the answers

What is the primary strategy to reduce inappropriate antibiotic use for upper respiratory tract infections (URTIs)?

<p>Educating patients on the viral nature of most URTIs. (B)</p> Signup and view all the answers

What is a key concept to consider when treating rhinosinusitis?

<p>High rate of spontaneous recovery (D)</p> Signup and view all the answers

What is the typical treatment duration for bacterial pharyngitis with penicillin in children?

<p>10 days (D)</p> Signup and view all the answers

What is one of the components of symptomatic management for acute pharyngitis?

<p>Acetaminophen (C)</p> Signup and view all the answers

What is the primary characteristic of acute rhinosinusitis?

<p>Inflammation of the mucosal lining of the nasal passage and paranasal sinuses (A)</p> Signup and view all the answers

The presence of what classifies acute bacterial rhinosinusitis as severe?

<p>High fever (≥ 39°C) and severe facial pain (D)</p> Signup and view all the answers

Which of the following is a common bacterial cause of acute bacterial rhinosinusitis?

<p>Streptococcus pneumoniae (B)</p> Signup and view all the answers

What is a key treatment consideration in managing acute bacterial rhinosinusitis?

<p>Considering the high rate of spontaneous recovery (C)</p> Signup and view all the answers

When should a switch to an alternate antibiotic be considered in treating rhinosinusitis?

<p>If symptoms worsen after 48-72 hours of treatment (C)</p> Signup and view all the answers

What is the primary cause of most cases of pharyngitis?

<p>Viral pathogens (D)</p> Signup and view all the answers

What is the most common bacterial cause of acute pharyngitis?

<p>Streptococcus pyogenes (D)</p> Signup and view all the answers

How is Group A Streptococcus (GAS) pharyngitis typically spread?

<p>Via respiratory droplets (A)</p> Signup and view all the answers

What is an appropriate adjunctive therapy recommendation for viral pharyngitis?

<p>Avoid aspirin use in children (B)</p> Signup and view all the answers

What is a potential delayed complication of Group A Streptococcus (GAS) infections?

<p>Rheumatic fever (A)</p> Signup and view all the answers

What is the primary characteristic of acute bronchitis?

<p>Inflammation and mucus in the airways in the lungs (C)</p> Signup and view all the answers

Which of the following is a typical symptom of acute bronchitis?

<p>Persistent cough (A)</p> Signup and view all the answers

What is generally recommended in the treatment of acute bronchitis?

<p>Symptomatic management (D)</p> Signup and view all the answers

What is a recommended strategy to reduce inappropriate antibiotic use for upper respiratory tract infections (URTIs)?

<p>Delayed prescription strategies (A)</p> Signup and view all the answers

Inflammation of the mucosal lining affecting the nasal passage and paranasal sinuses, with symptoms lasting less than 4 weeks, is best described as:

<p>Acute rhinosinusitis (C)</p> Signup and view all the answers

Approximately what proportion of adults in the United States are affected by sinusitis each year?

<p>1 in 7 (D)</p> Signup and view all the answers

A patient presents with nasal congestion, facial pain, and purulent nasal discharge. Which of these is classified as a MAJOR symptom in the clinical presentation of acute rhinosinusitis?

<p>Purulent nasal discharge (C)</p> Signup and view all the answers

Which diagnostic approach is generally considered LEAST necessary for diagnosing uncomplicated acute bacterial rhinosinusitis?

<p>Sinus aspiration and culture (B)</p> Signup and view all the answers

The majority of acute rhinosinusitis cases are attributed to which type of pathogen?

<p>Viral (A)</p> Signup and view all the answers

A patient with rhinosinusitis presents with symptoms for 8 days that are not worsening. Which of the following best indicates a VIRAL etiology rather than bacterial?

<p>Symptoms resolving within 5-6 days (D)</p> Signup and view all the answers

Which of the following bacterial pathogens is a primary cause of acute bacterial sinusitis?

<p><em>Streptococcus pneumoniae</em> (A)</p> Signup and view all the answers

Which key concept is MOST important to consider when treating acute bacterial rhinosinusitis (ABRS) in the outpatient setting?

<p>High rate of spontaneous resolution of ABRS (A)</p> Signup and view all the answers

For an adult patient diagnosed with acute bacterial rhinosinusitis, what is a typical first-line antibiotic treatment regimen?

<p>Amoxicillin-clavulanate for 5-7 days (D)</p> Signup and view all the answers

In pediatric patients with acute bacterial rhinosinusitis, a high dose of amoxicillin-clavulanate (45 mg/kg/day) is particularly recommended in which scenario?

<p>When there are high rates of penicillin non-susceptible <em>S. pneumoniae</em> in the community (C)</p> Signup and view all the answers

What is the recommended duration of antibiotic treatment for acute bacterial rhinosinusitis in adults?

<p>5-7 days (D)</p> Signup and view all the answers

Intranasal saline irrigation is recommended as what type of therapy in managing acute rhinosinusitis?

<p>Adjunctive therapy (C)</p> Signup and view all the answers

In a patient with acute bacterial rhinosinusitis who is nonresponsive to initial antibiotic therapy, when is it recommended to consider switching to an alternate antibiotic?

<p>If symptoms worsen after 48-72 hours of treatment (A)</p> Signup and view all the answers

Infectious Diseases Society of America (IDSA) guidelines recommend considering which antibiotic for acute bacterial rhinosinusitis?

<p>Amoxicillin with or without clavulanate (B)</p> Signup and view all the answers

Pharyngitis is MOST commonly caused by which type of pathogen?

<p>Viruses (B)</p> Signup and view all the answers

What is the estimated number of pediatrician/primary care visits annually in the US due to pharyngitis?

<p>15 million (A)</p> Signup and view all the answers

Group A Streptococcus (GAS) is the MOST common cause of what type of acute pharyngitis?

<p>Bacterial pharyngitis (D)</p> Signup and view all the answers

In children, approximately what proportion of sore throats are caused by Group A Streptococcus (GAS)?

<p>3 in 10 (C)</p> Signup and view all the answers

Which of the following clinical findings is MORE suggestive of viral pharyngitis compared to Group A Strep pharyngitis?

<p>Cough and rhinorrhea (C)</p> Signup and view all the answers

When is testing for Group A Streptococcus (GAS) pharyngitis generally NOT recommended?

<p>In children with viral features like cough and rhinorrhea (C)</p> Signup and view all the answers

What is the typical mode of transmission for Group A Streptococcus (GAS) pharyngitis?

<p>Respiratory droplets and direct contact (A)</p> Signup and view all the answers

What is the recommended duration of treatment for Group A Streptococcus (GAS) pharyngitis with oral penicillin?

<p>10 days (A)</p> Signup and view all the answers

In children with pharyngitis, which adjunctive therapy should be avoided?

<p>Aspirin (D)</p> Signup and view all the answers

Rheumatic fever is a potential delayed sequela of infection caused by which pathogen?

<p>Group A Streptococcus (GAS) (A)</p> Signup and view all the answers

What is the primary goal of antibiotic therapy in treating Group A Streptococcus (GAS) pharyngitis?

<p>To prevent rheumatic fever (A)</p> Signup and view all the answers

According to clinical practice guidelines from IDSA, what is the recommended approach for managing Group A Streptococcal Pharyngitis?

<p>Management focused on antibiotic therapy and prevention of rheumatic fever (A)</p> Signup and view all the answers

Acute bronchitis is primarily characterized by inflammation of:

<p>The large airways in the lungs (A)</p> Signup and view all the answers

What is the typical duration of cough associated with acute bronchitis?

<p>1-3 weeks (B)</p> Signup and view all the answers

What is the MOST common etiology of acute bronchitis?

<p>Viral infection (B)</p> Signup and view all the answers

Which of the following symptoms is commonly associated with acute bronchitis?

<p>Persistent cough (A)</p> Signup and view all the answers

Which clinical finding is MORE suggestive of pneumonia rather than acute bronchitis?

<p>Tachypnea and dyspnea (B)</p> Signup and view all the answers

The primary approach to managing acute bronchitis in otherwise healthy adults is:

<p>Supportive care and symptomatic management (C)</p> Signup and view all the answers

Which of the following is a recommended component of symptomatic management for acute bronchitis?

<p>Humidifier or cool mist vaporizer (D)</p> Signup and view all the answers

In the management of acute bronchitis, what should be generally discouraged?

<p>Routine use of antibiotics (A)</p> Signup and view all the answers

What is a significant risk associated with the overprescribing of antibiotics for upper respiratory infections?

<p>Development of antimicrobial resistance (D)</p> Signup and view all the answers

Which of the following is a strategy to reduce inappropriate antibiotic use for upper respiratory tract infections (URTIs)?

<p>Delayed prescription strategies (A)</p> Signup and view all the answers

What is a key message to communicate to patients to prevent them from expecting antibiotics for viral infections like a chest cold?

<p>Most chest colds are caused by viruses, and antibiotics are not effective against viruses. (A)</p> Signup and view all the answers

What is the primary strategy for reducing inappropriate antibiotic use in the context of upper respiratory tract infections (URTIs)?

<p>Promoting delayed antibiotic prescriptions and watchful waiting (B)</p> Signup and view all the answers

Which of the following is a component of symptomatic management for acute pharyngitis, regardless of etiology?

<p>Acetaminophen or NSAIDs for pain relief (A)</p> Signup and view all the answers

What is the primary characteristic defining acute rhinosinusitis?

<p>Inflammation of the nasal passages and paranasal sinuses lasting less than 4 weeks (D)</p> Signup and view all the answers

The presence of which symptom, in acute bacterial rhinosinusitis, classifies it as 'severe'?

<p>Severe facial pain (C)</p> Signup and view all the answers

Which of the following is a common bacterial cause of acute bacterial rhinosinusitis (ABRS)?

<p><em>Streptococcus pneumoniae</em> (A)</p> Signup and view all the answers

A 35-year-old patient presents with nasal congestion, facial pain, and purulent nasal discharge for 6 days which started after a week of clear nasal discharge and mild cough. Which of the following best differentiates a bacterial etiology from a viral etiology in this case of acute rhinosinusitis?

<p>The lack of improvement after 5-6 days since symptom onset. (B)</p> Signup and view all the answers

Which of the following bacterial pathogens is the MOST common cause of acute bacterial rhinosinusitis (ABRS)?

<p><em>Streptococcus pneumoniae</em> (B)</p> Signup and view all the answers

What is the generally recommended duration of antibiotic therapy for an adult diagnosed with uncomplicated acute bacterial rhinosinusitis?

<p>5-7 days (D)</p> Signup and view all the answers

In a pediatric patient with acute bacterial rhinosinusitis, when is high-dose amoxicillin-clavulanate (45 mg/kg/day) particularly recommended as the first-line treatment?

<p>In cases where there is a high local prevalence of penicillin-nonsusceptible <em>Streptococcus pneumoniae</em>. (A)</p> Signup and view all the answers

A 6-year-old child is diagnosed with acute bacterial rhinosinusitis. What is the typical duration of antibiotic treatment recommended for pediatric patients?

<p>10-14 days (D)</p> Signup and view all the answers

Which of the following is an appropriate adjunctive therapy to recommend to a patient with acute rhinosinusitis to help relieve symptoms?

<p>Intranasal saline irrigation (C)</p> Signup and view all the answers

A patient with acute bacterial rhinosinusitis has been treated with amoxicillin-clavulanate for 3 days and reports no improvement in symptoms, but also no worsening. When should a switch to an alternate antibiotic be considered?

<p>If there is no improvement after 3-5 days of antibiotic treatment. (A)</p> Signup and view all the answers

What is the MOST common etiology of pharyngitis?

<p>Viral infections (B)</p> Signup and view all the answers

Which clinical finding is MORE suggestive of Group A Streptococcal (GAS) pharyngitis compared to viral pharyngitis?

<p>Tonsillar exudates (B)</p> Signup and view all the answers

What is the recommended duration of treatment with oral penicillin for Group A Streptococcus (GAS) pharyngitis to prevent the development of rheumatic fever?

<p>10 days (D)</p> Signup and view all the answers

In managing a 7-year-old child with pharyngitis, which of the following adjunctive therapies should be avoided due to potential risks?

<p>Aspirin (C)</p> Signup and view all the answers

Rheumatic fever is a potential delayed sequela of infection caused by which specific pathogen?

<p><em>Streptococcus pyogenes</em> (Group A Streptococcus) (C)</p> Signup and view all the answers

To reduce inappropriate antibiotic use for upper respiratory tract infections (URTIs), what is a key communication strategy for healthcare providers when speaking with patients?

<p>All of the above are key communication strategies. (D)</p> Signup and view all the answers

A 45-year-old patient presents with symptoms suggestive of acute rhinosinusitis. Which of the following clinical findings would most strongly suggest a bacterial rather than a viral etiology?

<p>Onset of symptoms with persistent purulent nasal discharge for 12 days. (C)</p> Signup and view all the answers

In the outpatient management of acute bacterial rhinosinusitis (ABRS) in adults, which factor would most strongly support the recommendation for high-dose amoxicillin-clavulanate (2000/125 mg BID) over standard-dose amoxicillin-clavulanate (875/125 mg BID)?

<p>Patient resides in a community with a high prevalence of penicillin-non-susceptible <em>Streptococcus pneumoniae</em>. (D)</p> Signup and view all the answers

A 5-year-old child is diagnosed with acute bacterial rhinosinusitis and prescribed amoxicillin-clavulanate. After 72 hours, the child's parent reports no significant improvement in symptoms, but also no worsening. What is the most appropriate next step in managing this patient?

<p>Reassure the parent that improvement may take longer and to continue observing for another 2-3 days before reconsidering therapy. (D)</p> Signup and view all the answers

Which of the following adjunctive therapies for acute rhinosinusitis has the strongest evidence supporting its recommendation in clinical guidelines?

<p>Nasal saline irrigation. (C)</p> Signup and view all the answers

A patient with acute bacterial rhinosinusitis (ABRS) is being treated with amoxicillin-clavulanate. Which scenario would warrant considering a switch to an alternative antibiotic due to treatment failure?

<p>Symptoms worsen significantly after 72 hours of initiating antibiotics. (C)</p> Signup and view all the answers

In differentiating between viral and Group A Streptococcal (GAS) pharyngitis, which clinical finding is most suggestive of GAS pharyngitis?

<p>Tonsillar exudates and tender anterior cervical lymphadenopathy. (D)</p> Signup and view all the answers

A 6-year-old child presents with acute pharyngitis. A rapid antigen detection test (RADT) for Group A Streptococcus (GAS) is negative. Viral features such as cough and rhinorrhea are absent. What is the most appropriate next step in management?

<p>Obtain a throat culture for GAS to confirm the negative RADT result. (D)</p> Signup and view all the answers

Which of the following best describes the primary goal of antibiotic therapy in the treatment of Group A Streptococcal (GAS) pharyngitis?

<p>To prevent the delayed non-suppurative sequela of acute rheumatic fever. (B)</p> Signup and view all the answers

For a child with a confirmed Group A Streptococcus (GAS) pharyngitis and no penicillin allergy, which of the following is the recommended duration of treatment with oral penicillin to prevent rheumatic fever?

<p>10 days (B)</p> Signup and view all the answers

In managing a 4-year-old child with viral pharyngitis, which of the following adjunctive therapies should be avoided due to lack of benefit and potential risks in this age group?

<p>Oral corticosteroids to reduce inflammation. (D)</p> Signup and view all the answers

Which of the following is the most accurate description of acute bronchitis?

<p>Inflammation of the large airways (bronchi) primarily viral in etiology, characterized by cough. (B)</p> Signup and view all the answers

A patient presents with a cough for 10 days, associated with clear sputum, mild chest discomfort, and wheezing. Which of the following clinical findings would be most suggestive of pneumonia rather than acute bronchitis?

<p>Tachypnea and dyspnea. (B)</p> Signup and view all the answers

What is the primary approach to managing acute bronchitis in an otherwise healthy adult patient?

<p>Symptomatic management and supportive care, avoiding routine antibiotic use. (A)</p> Signup and view all the answers

In the context of acute bronchitis management, what is the most significant risk associated with the overprescription of antibiotics?

<p>Development of bacterial antibiotic resistance and adverse drug events. (C)</p> Signup and view all the answers

Which strategy is most effective in reducing inappropriate antibiotic use for upper respiratory tract infections (URTIs) in outpatient settings?

<p>Implementing delayed prescription strategies and patient education on viral illnesses. (D)</p> Signup and view all the answers

When communicating with patients about upper respiratory tract infections (URTIs), which message is most crucial to convey to reduce patient expectations for antibiotics?

<p>Most chest colds and sinus infections are caused by viruses, which antibiotics cannot treat. (B)</p> Signup and view all the answers

In the context of antibiotic stewardship for upper respiratory infections, what is the initial, most important step in clinical decision-making?

<p>Accurately differentiating between viral and bacterial etiologies. (B)</p> Signup and view all the answers

For acute bacterial rhinosinusitis (ABRS), which key concept most significantly influences outpatient treatment decisions?

<p>The high rate of spontaneous resolution in uncomplicated cases and the need to minimize antibiotic use. (B)</p> Signup and view all the answers

Which of the following scenarios represents a situation where testing for Group A Streptococcus (GAS) pharyngitis would generally NOT be recommended?

<p>A 2-year-old child presenting with mild sore throat, cough, rhinorrhea, and oral ulcers. (D)</p> Signup and view all the answers

What is the typical duration of cough associated with acute bronchitis, which should be communicated to patients to manage expectations?

<p>2-3 weeks (approximately 18 days). (B)</p> Signup and view all the answers

A patient with acute bronchitis is considering using over-the-counter (OTC) medications for symptom relief. Which of the following OTC medication classes should generally be avoided or used with caution, particularly in young children, due to minimal benefit and potential risks?

<p>Antihistamines and antitussives. (B)</p> Signup and view all the answers

Which of the following best describes 'worsening' acute bacterial rhinosinusitis (ABRS) as a differentiator from viral rhinosinusitis?

<p>Symptoms initially improve but then worsen after 5-6 days. (C)</p> Signup and view all the answers

In pediatric acute bacterial rhinosinusitis (ABRS), when is the use of high-dose amoxicillin-clavulanate (45 mg/kg/day) particularly recommended as first-line therapy?

<p>When there is concern for penicillin-resistant <em>Streptococcus pneumoniae</em>, such as daycare attendance or recent antibiotic use. (A)</p> Signup and view all the answers

What is the most common viral etiology of acute bronchitis?

<p>Rhinovirus. (C)</p> Signup and view all the answers

Which of the following is a potential delayed non-suppurative sequela specifically associated with Group A Streptococcus (GAS) infections, such as pharyngitis?

<p>Acute glomerulonephritis and rheumatic fever. (B)</p> Signup and view all the answers

In managing Group A Streptococcal (GAS) pharyngitis, clinical practice guidelines from the Infectious Diseases Society of America (IDSA) recommend which approach?

<p>Selective testing and treatment based on clinical and epidemiological criteria to prevent rheumatic fever. (C)</p> Signup and view all the answers

Which of the following best exemplifies a 'delayed prescription' strategy for managing upper respiratory tract infections (URTIs) to reduce antibiotic use?

<p>Immediately prescribing an antibiotic but advising the patient to wait 3-5 days before filling it unless symptoms worsen or persist. (C)</p> Signup and view all the answers

What is the estimated proportion of adult sore throats that are caused by Group A Streptococcus (GAS)?

<p>Roughly 10%. (D)</p> Signup and view all the answers

Which of the following symptoms is LEAST likely to be associated with acute bronchitis and would warrant consideration of an alternative diagnosis such as pneumonia?

<p>Significant dyspnea and tachypnea. (D)</p> Signup and view all the answers

In the context of acute rhinosinusitis, what does the term 'severe' acute bacterial rhinosinusitis (ABRS) primarily indicate?

<p>Severe facial pain, high fever (≥ 39°C), and toxic appearance. (B)</p> Signup and view all the answers

Which of the following is considered a 'major' symptom in the clinical presentation of acute rhinosinusitis according to clinical guidelines?

<p>Purulent nasal discharge. (D)</p> Signup and view all the answers

Which of the following diagnostic approaches is generally considered LEAST necessary for diagnosing uncomplicated acute bacterial rhinosinusitis (ABRS) in an outpatient setting?

<p>Imaging studies such as sinus X-rays or CT scans. (B)</p> Signup and view all the answers

What is the typical treatment duration for acute bacterial rhinosinusitis (ABRS) with antibiotics in adults, according to clinical guidelines?

<p>5-7 days. (C)</p> Signup and view all the answers

Which of the following antibiotics is recommended by the Infectious Diseases Society of America (IDSA) guidelines as a first-line treatment option for acute bacterial rhinosinusitis (ABRS) in adults?

<p>Amoxicillin-clavulanate. (C)</p> Signup and view all the answers

In the treatment of acute pharyngitis, when is a follow-up throat culture most strongly recommended after a negative rapid antigen detection test (RADT) for Group A Streptococcus (GAS)?

<p>In children and adolescents when viral features are absent and clinical suspicion for GAS remains high. (C)</p> Signup and view all the answers

What is the most common age group for the occurrence of rheumatic fever as a sequela of Group A Streptococcus (GAS) infection?

<p>Children aged 5-15 years. (C)</p> Signup and view all the answers

According to the clinical practice guidelines, what is the recommended management of Group A Streptococcal Pharyngitis?

<p>Use clinical and epidemiological criteria to guide testing and treatment, focusing on preventing rheumatic fever. (B)</p> Signup and view all the answers

A 40-year-old patient presents with acute rhinosinusitis symptoms for 12 days, including persistent nasal congestion and purulent discharge. The symptoms have remained consistent without significant improvement or worsening since onset. Which of the following clinical features, if present, would most strongly suggest a bacterial etiology over a viral etiology in this patient's rhinosinusitis?

<p>Unilateral predominance of purulent nasal discharge and severe facial pain. (C)</p> Signup and view all the answers

In the outpatient management of acute bacterial rhinosinusitis (ABRS) for an adult patient with no known penicillin allergy and no significant comorbidities, which of the following factors would most compellingly advocate for the use of high-dose amoxicillin-clavulanate (2000/125 mg BID) over standard-dose amoxicillin-clavulanate (875/125 mg BID) as first-line therapy?

<p>Patient has moderate to severe pain, as indicated by a visual analog scale score of 7/10, and temperature of 38.5°C. (D)</p> Signup and view all the answers

A 7-year-old child is diagnosed with acute bacterial rhinosinusitis and initiated on amoxicillin-clavulanate. After 72 hours of treatment, the parent reports that the child's symptoms, including nasal discharge and facial pain, have shown minimal improvement but have not worsened. Which of the following is the most clinically appropriate next step in managing this patient?

<p>Continue amoxicillin-clavulanate for another 48-72 hours as clinical improvement may still be forthcoming. (B)</p> Signup and view all the answers

Which of the following adjunctive therapies for acute rhinosinusitis has the most robust evidence base supporting its recommendation for symptomatic relief in clinical practice guidelines?

<p>Intranasal saline irrigation. (A)</p> Signup and view all the answers

A 50-year-old patient with acute bacterial rhinosinusitis (ABRS) is being treated with amoxicillin-clavulanate. After 5 days of therapy, the patient reports persistent severe headache, worsening facial pain, and new onset of periorbital edema. Which of the following clinical scenarios would most strongly warrant considering a switch to an alternative antibiotic and further diagnostic evaluation?

<p>Patient develops new neurological symptoms such as altered mental status or vision changes. (A)</p> Signup and view all the answers

In differentiating between viral and Group A Streptococcal (GAS) pharyngitis in a 10-year-old child presenting with acute sore throat, which of the following clinical findings is most suggestive of GAS pharyngitis rather than a viral etiology?

<p>Abrupt onset of severe sore throat, odynophagia, and tonsillar exudates. (B)</p> Signup and view all the answers

A 5-year-old child presents with acute pharyngitis. A rapid antigen detection test (RADT) for Group A Streptococcus (GAS) is performed in the clinic and is negative. Viral features such as cough, rhinorrhea, and conjunctivitis are notably absent during the clinical examination. What is the most appropriate next step in the management of this child?

<p>Obtain a throat culture for GAS to confirm the negative RADT result, and withhold antibiotics pending culture results. (C)</p> Signup and view all the answers

For a 9-year-old child with a confirmed Group A Streptococcus (GAS) pharyngitis and no penicillin allergy, which of the following is the guideline-recommended duration of treatment with oral penicillin to prevent rheumatic fever?

<p>10 days (D)</p> Signup and view all the answers

In managing a 4-year-old child with viral pharyngitis, which of the following adjunctive therapies should be avoided or used with caution due to lack of proven benefit and potential risks in this age group?

<p>Over-the-counter cough and cold medications containing antihistamines and antitussives. (A)</p> Signup and view all the answers

Which of the following best describes the pathophysiology of acute bronchitis?

<p>Inflammation of the large airways, specifically the bronchi, leading to mucus production and cough. (B)</p> Signup and view all the answers

A 68-year-old patient presents with a cough for 12 days, productive of clear sputum, associated with mild chest discomfort and wheezing. Which of the following clinical findings, if present, would be most concerning and suggestive of pneumonia rather than uncomplicated acute bronchitis?

<p>Oxygen saturation of 92% on room air and respiratory rate of 24 breaths per minute. (B)</p> Signup and view all the answers

In the context of acute bronchitis management, what is the most significant and broadly applicable risk associated with the overprescription of antibiotics?

<p>Development and spread of antimicrobial resistance. (D)</p> Signup and view all the answers

To effectively reduce inappropriate antibiotic use for upper respiratory tract infections (URTIs) in outpatient settings, which of the following strategies is considered most impactful at the healthcare provider level?

<p>Utilizing delayed prescription strategies and providing clear communication about viral illnesses. (C)</p> Signup and view all the answers

When communicating with patients about upper respiratory tract infections (URTIs) like acute bronchitis or viral rhinosinusitis, which of the following key messages is most crucial to convey to manage patient expectations and reduce antibiotic demand?

<p>Antibiotics are ineffective against viral infections and will not help you get better faster. (C)</p> Signup and view all the answers

Flashcards

Differentiate Etiologies of URTIs

Distinguishing between infections caused by bacteria versus viruses.

Describe URTIs (Sinusitis, Pharyngitis, Bronchitis)

Understanding the microbial agents, spread, disease signs, diagnosis methods, and treatments for infections like sinus infections, sore throat, and acute bronchitis.

Discuss Overprescribing of Antibiotics for URTIs

Explaining why antibiotics are often unnecessarily prescribed for upper respiratory infections, and finding ways to reduce this overuse.

Acute Rhinosinusitis

Inflammation of sinuses usually lasting less than 4 weeks.

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Sinusitis Presentation

Purulent nasal discharge, nasal congestion, facial pain/pressure. Major or minor symptoms.

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Sinusitis Diagnosis

Compatible symptoms with bacterial vs viral cause, sinus aspiration, imaging studies.

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Bacterial vs. Viral Sinusitis

Onset with persistent symptoms lasting at least 10 days. Severe symptoms, or worsening symptoms

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Common Sinusitis Bacteria

Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis.

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Sinusitis Treatment Concepts

High rate of spontaneous recovery, viral vs. bacterial, lack of microbiologic info, antimicrobial resistance.

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First-line Sinusitis Treatment

Amoxicillin-clavulanate 5-7 days in adults or 10-14 days in pediatrics.

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Pharyngitis

Infection of the oropharynx, predominately caused by virus. Called “Strep throat” when caused by Streptococcus pyogenes

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Pharyngitis Etiology

Upper Respiratory Viruses, Streptococcus pyogenes (GAS).

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Strep Throat Cause

Group A Streptococcus (GAS) by Streptococcus pyogenes.

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Strep Throat Symptoms

Sore throat, tonsillar exudates, tender lymph nodes, fever.

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Pharyngitis Symptoms

GAS symptoms: headache, abdominal pain, nausea/vomiting. Viral: cough, rhinorrhea, hoarseness, oral ulcers, conjunctivitis.

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Strep Throat Diagnosis

Throat swab and rapid antigen detection testing (RADT) and/or culture.

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Strep Throat Treatment

Penicillin or amoxicillin for 10 days

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Acute Bronchitis

Infection/inflammation of airways in the lungs for up to 3 weeks

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Bronchitis Etiology

Viruses (Rhinovirus, Influenza, Coronavirus).

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Bronchitis Symptoms

Cough (+/- mucus), nasal congestion, chest soreness, fatigue.

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Bronchitis Treatment

Supportive care and symptom management is key.

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Pneumonia Indicators

Tachypnea, tachycardia, dyspnea, and radiologic findings.

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Reducing Antibiotic Use

Delayed prescription strategies and address patient concerns, emphasize viral illness.

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Antibiotic Overuse Consequences

Risks include adverse effects, antimicrobial resistance, and unnecessary costs.

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Differentiate Viral & Bacterial URTIs

Distinguish between infections caused by environmental agents versus self-resolving pathogens.

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Describe Microbiology, Epidemiology, Clinical Profile, Diagnosis, & Treatment

Detail germ types, how infections spread/affect, diagnostic approaches and treatments for sinus, throat and lower bronchial infections.

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Discuss Antibiotic Overuse for URTIs

To highlight the frequent misuse of antibiotics and promote ways to minimize this problem.

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Define Acute Rhinosinusitis

Inflammation of the mucosal lining of the nasal passage and paranasal sinuses, lasting less than 4 weeks.

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Recognizing Bacterial Sinusitis

Compatible signs and symptoms lasting ≥ 10 days without improvement, High fever alongside purulent nasal discharge, new onset fever and/or headache following typical viral URTI

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Identify Common Bacterial Sinusitis Pathogens

The most common bacterial causes are Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis.

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Outline Appropriate Acute Bacterial Rhinosinusitis Treatment

Amoxicillin-clavulanate is a common first-line antibiotics, use 5-7 days for adults, 10-14 days for pediatrics.

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Define pharyngitis

Infection of the oropharynx commonly caused by viral pathogens, the bacterial cause Streptococcus pyogenes is known as strep throat

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How To Test For GAS (group A streptococcus)

Test throat swab and rapid antigen detection testing (RADT) and/or culture; GAS (group A streptococcus)

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Goals of therapy

The goals include, preventing the spread of infection to others. Promote infection resolution, minimize adverse effects, prevent rheumatic fever.

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Outline Appropriate Acute Bronchitis Treatment

Supportive care and symptom management, fluids and rest, humidifier, OTC pain/fever medications, recommend against antibiotic use unless pertussis is present

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List Strategies To Reduce Antibiotic Use

Strategies include, delayed prescription, answering patient concerns, explaining illness course, discussing non-antibiotic options and stress infection is viral or described as a chest cold

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Study Notes

  • Differentiate between bacterial and viral etiologies of Upper Respiratory Tract Infections (URTIs).
  • Describe the microbiology, epidemiology, clinical manifestations, diagnosis, and treatment of sinusitis, pharyngitis, and acute bronchitis.
  • Discuss the overprescribing of antibiotics for URTIs and strategies to reduce inappropriate use.

Acute Rhinosinusitis

  • Acute rhinosinusitis involves inflammation of the mucosal lining in the nasal passage and paranasal sinuses.
  • Acute rhinosinusitis lasts for less than 4 weeks.
  • Sinusitis impacts 1 in 7 adults in the U.S. annually.
  • Sinusitis is the 5th most common diagnosis responsible for antibiotic therapy.
  • Major clinical presentations include purulent nasal discharge, nasal congestion or obstruction, facial congestion or fullness, and facial pain or pressure.
  • Minor clinical presentations include hyposmia or anosmia, fever, headache, ear pain/pressure/fullness, halitosis, dental pain, cough, and fatigue.
  • Diagnosis involves sinus aspiration and culture, imaging studies, compatible signs and symptoms, and differentiating bacterial vs. viral etiologies.
  • Viral causes account for 90-98% of rhinosinusitis cases, including rhinoviruses, coronaviruses, influenza viruses, and adenoviruses.
  • Bacterial causes account for 2-10% of rhinosinusitis cases.
  • Presistent symptoms last greater than 10 days without improvement and can indicate bacterial infections.
  • Severe symptoms, like high fever (≥ 39° C) and purulent nasal discharge or facial pain lasting ≥ 3-4 days can indicate bacterial infections.
  • Worsening symptoms, including new onset fever, headache, and increased discharge following a typical viral URTI lasting 5-6 days, can indicate bacterial infections.
  • Common bacterial causes of sinusitis are Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis.
  • Spontaneous recovery from sinusitis is common.
  • There is often a lack of microbiologic information, antibiotics should be initiated once acute bacterial rhinosinusitis (ABRS) is established.
  • Increasing antimicrobial resistance is a key concept in treatment.
  • Amoxicillin-clavulanate is used for ABRS outpatient treatment.
    • Adults: 500/125 mg orally three times daily or 875/125 mg orally twice daily.
    • High dose: 2000/125 mg orally twice daily.
    • Pediatrics: 45 mg/kg/day orally, divided twice daily.
    • High dose: 45 mg/kg orally twice daily.
  • A high dose of Amoxicillin-clavulanate is needed if there are high rates of penicillin non-susceptible S. pneumoniae (≥ 10%), severe infection (≥ 39° C), age < 2 or > 65 years, recent hospitalization, antibiotic use within the past month, daycare attendance, or the patient is immunocompromised.
  • Alternative therapies for adults include doxycycline 100 mg orally twice daily, levofloxacin 500 mg orally daily, or moxifloxacin 400 mg orally daily.
  • Alternative therapies for pediatrics include levofloxacin 10-20 mg/kg/day orally every 12-24 hours or clindamycin 30-40 mg/kg/day orally three times daily + cefixime 8 mg/kg/day orally twice daily OR cefpodoxime 10 mg/kg/day orally twice daily.
  • Severe disease may require IV antibiotics.
  • Treatment duration is 5-7 days for adults and 10-14 days for pediatrics.
  • Intranasal saline irrigation and intranasal corticosteroids in allergic rhinitis are adjunctive therapies.
  • Decongestants and antihistamines are not recommended.
  • Switch to an alternate antibiotic for symptoms worsening after 48-72 hours, or failure to improve after 3-5 days of empiric antibiotics.
  • Important considerations include resistant pathogens, noninfectious etiology, structural abnormality, and other causes for treatment failure.
  • Culture is recommended for nonresponsive patients.
  • Clinical Practice Guidelines include the Infectious Diseases Society of America (IDSA) - 2012, and American Academy of Otolaryngology – Head and Neck Surgery – 2015 (adult only).
    • The American Academy of Otolaryngology recommends Amoxicillin with/without clavulanate for 5-10 days for adults only.

Pharyngitis

  • Pharyngitis is an infection of the oropharynx.
  • It is predominately caused by viral pathogens, including adenovirus, influenza, parainfluenza, rhinovirus, RSV, Epstein-Barr virus, coxsackievirus, and HSV.
  • "Strep throat" is acute pharyngitis caused by Streptococcus pyogenes.
  • There are 15 million pediatrician/primary care visits per year in the U.S. due to pharyngitis.
  • It is most common in children ages 5-15.
  • Group A strep pharyngitis is caused by Streptococcus pyogenes (Group A strep - GAS).
  • GAS is the most common bacterial cause of acute pharyngitis.
  • In children, 3/10 sore throats are GAS strep throat.
  • In adults, 1/10 sore throats are GAS strep throat.
  • Group A strep pharyngitis most commonly occurs in winter and early spring.
  • Other GAS symptoms: headache, abdominal pain, and nausea/vomiting.
  • Viral symptoms include cough, rhinorrhea, hoarseness, oral ulcers, and conjunctivitis.
  • Clinical findings include tonsillopharyngeal erythema +/- exudates, tender or enlarged lymph nodes, a red swollen uvula, petechiae on the palate, and a scarlatiniform rash.
  • Diagnosis inolves a throat swab and rapid antigen detection testing (RADT) and/or culture.
  • Testing is not recommended if viral features are present or in children < 3 years old.
  • Transmission of pharyngitis occurs through respiratory droplets and direct contact.
  • The incubation period is 2-5 days.
  • Treatment options for GAS only:
  • Penicillin V: Children: 250 mg orally 2-3x/day; Adults: 250 mg orally 4x/day or 500 mg orally twice daily for 10 days.
  • Amoxicillin: 25 mg/kg (max 500 mg) orally twice daily or 50 mg/kg/day (max 1000 mg) orally for 10 days.
  • Benzathine penicillin G: < 27 kg: 600,000 U intramuscular; ≥ 27 kg: 1,200,000 U intramuscular (1 dose).
  • If the patient has a Penicillin Allergy:
  • Cephalexin is 20 mg/kg orally twice daily (max 500 mg/dose) for 10 days.
  • Cefadroxil is 30 mg/kg/day orally (max 1g) for 10 days.
  • Clindamycin is 7 mg/kg orally three times a day (max 300 mg/dose) for 10 days.
  • Azithromycin is 12 mg/kg/day orally (max 500 mg) for 5 days.
  • Clarithromycin is 7.5 mg/kg orally twice daily (max 250 mg/dose) for 10 days.
  • Adjunctive therapy is using Acetaminophen or NSAIDs.
  • Avoid aspirin in children and Corticosteroids are not recommended
  • Rheumatic fever is a delayed sequela of some GAS infections
  • It is an immune response, not an infection
  • Rheumatic fever is the leading cause of pediatric acquired heart disease in some countries
  • It can occur 1-5 weeks after initial infection
  • Symptoms: fever, arthritis, chest pain, shortness of breath, tachycardia, fatigue, chorea, nodules, rash, heart murmur, enlarged heart, fluid around the heart
  • Most common ages are 5-15 years old
  • Rheumatic fever can be treated with treatment of underlying GAS and symptom management
  • Goals of therapy:
  • Prevent spread of infection to others
  • Infection resolution
  • Minimize treatment adverse effects
  • Prevent rheumatic fever
  • Clinical Practice Guidelines include Infectious Diseases Society of America (IDSA) – 2012 regarding the management of Group A Streptococcal Pharyngitis

Bronchitis

  • Acute bronchitis involves inflammation and mucus in the airways in the lungs, and can last up to 3 weeks.
  • Bronchitis is characterized by persistent cough, and is also described as a "chest cold".
  • 5% of the U.S. population reports acute bronchitis annually.
  • Acute bronchitis accounts for > 10 million office visits annually.
  • Most cases of bronchitis is commonly caused by a virus.
  • A bacterial cause is seen in 1-10% of cases.
  • Symptoms include cough (+/- mucus), nasal congestion, chest soreness, fatigue, headache, body aches, sore throat, and fever.
  • Symptom duration is typically 2-3 weeks (18 days).
  • Laboratory testing is not indicated, and infrequent leukocytosis is seen.
  • Specific pathogen testing is only needed if highly suspicious and treatment would be impacted.
  • Treatment involves supportive care and symptom management.
  • It is recommended against the use of antibiotics, with the exception of pertussis (macrolide).
  • Symptomatic management: fluids, rest, humidifier/cool mist vaporizer, nasal saline, breathe in steam, lozenges, honey.
  • OTC medications can be used, such as (APAP, ibuprofen, antihistamines, decongestants), but there is minimal benefit.
  • Avoid antihistamines and antitussives in young children
  • Findings Suggestive of Pneumonia:
  • Tachypnea
  • Tachycardia
  • Dyspnea
  • Radiologic findings
  • Clinical Practice Resource: American Academy of Family Physician – Acute Bronchitis (2012).

Antibiotic Overprescribing

  • Risks of Overprescribing
  • Adverse effects
  • Antimicrobial resistance
  • Unnecessary costs
  • Strategies to Reduce Inappropriate Antibiotic Use
  • Delayed prescription strategies
  • Address patient concerns in a compassionate manner
  • Expected course of illness and cough duration
  • Explain that antibiotics do not significantly shorten illness duration and are associated with adverse effects and antibiotic resistance
  • Discuss the use of nonantibiotic medications to control symptoms
  • Describe the infection as a viral illness or chest cold

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