10 Questions
What is the state associated with pregnancy?
Hypercoagulable state
Why is warfarin not recommended for use in pregnancy?
It is associated with fetal abnormalities and haemorrhagic complications
What is the advantage of using low molecular weight heparins (LMWH) over heparin?
LMWH has better and more predictable pharmacokinetics
For how long can subcutaneous LMWH be continued in pregnant patients?
Throughout pregnancy and for six weeks post partum
In which patients is warfarin often given up to 36 weeks of pregnancy?
Patients with prosthetic heart valves
Heparin crosses the placenta.
False
Warfarin is a preferred option for pregnant women with prosthetic heart valves.
True
Low molecular weight heparins (LMWH) have unpredictable pharmacokinetics.
False
Pregnancy is associated with a hypocoagulable state.
False
Subcutaneous LMWH can only be continued until the end of pregnancy.
False
Study Notes
Pregnancy and Coagulation
- Pregnancy is associated with a hypercoagulable state.
Warfarin in Pregnancy
- Warfarin is associated with nasal hypoplasia and chondrodysplasia in the first trimester.
- Warfarin is linked to CNS abnormalities in late pregnancy.
- Warfarin use in pregnancy can lead to haemorrhagic complications.
- Warfarin is not recommended for use in pregnancy unless there are no other options.
Heparin in Pregnancy
- Heparin does not cross the placenta.
- Low molecular weight heparins (LMWH) are preferred due to better and more predictable pharmacokinetics.
- Subcutaneous LMWH can be continued throughout pregnancy and for the prothrombotic six weeks post partum.
Special Considerations
- Patients with prosthetic heart valves may require warfarin despite the risks to the fetus.
- Warfarin may be given up to 36 weeks in patients with prosthetic heart valves.
Pregnancy and Coagulation
- Pregnancy is associated with a hypercoagulable state.
Warfarin in Pregnancy
- Warfarin is associated with nasal hypoplasia and chondrodysplasia in the first trimester.
- Warfarin is linked to CNS abnormalities in late pregnancy.
- Warfarin use in pregnancy can lead to haemorrhagic complications.
- Warfarin is not recommended for use in pregnancy unless there are no other options.
Heparin in Pregnancy
- Heparin does not cross the placenta.
- Low molecular weight heparins (LMWH) are preferred due to better and more predictable pharmacokinetics.
- Subcutaneous LMWH can be continued throughout pregnancy and for the prothrombotic six weeks post partum.
Special Considerations
- Patients with prosthetic heart valves may require warfarin despite the risks to the fetus.
- Warfarin may be given up to 36 weeks in patients with prosthetic heart valves.
This quiz covers the effects of pregnancy on blood coagulation and the use of anticoagulants like warfarin and heparin during pregnancy. Learn about the risks and complications associated with their use.
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