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Questions and Answers
What is the state associated with pregnancy?
What is the state associated with pregnancy?
- Hypocoagulable state
- Thrombotic state
- Homeostatic state
- Hypercoagulable state (correct)
Why is warfarin not recommended for use in pregnancy?
Why is warfarin not recommended for use in pregnancy?
- It is not effective in preventing blood clots
- It is not approved by the FDA for use in pregnancy
- It is too expensive
- It is associated with fetal abnormalities and haemorrhagic complications (correct)
What is the advantage of using low molecular weight heparins (LMWH) over heparin?
What is the advantage of using low molecular weight heparins (LMWH) over heparin?
- LMWH is easier to administer
- LMWH has better and more predictable pharmacokinetics (correct)
- LMWH is cheaper
- LMWH is more effective in preventing blood clots
For how long can subcutaneous LMWH be continued in pregnant patients?
For how long can subcutaneous LMWH be continued in pregnant patients?
In which patients is warfarin often given up to 36 weeks of pregnancy?
In which patients is warfarin often given up to 36 weeks of pregnancy?
Heparin crosses the placenta.
Heparin crosses the placenta.
Warfarin is a preferred option for pregnant women with prosthetic heart valves.
Warfarin is a preferred option for pregnant women with prosthetic heart valves.
Low molecular weight heparins (LMWH) have unpredictable pharmacokinetics.
Low molecular weight heparins (LMWH) have unpredictable pharmacokinetics.
Pregnancy is associated with a hypocoagulable state.
Pregnancy is associated with a hypocoagulable state.
Subcutaneous LMWH can only be continued until the end of pregnancy.
Subcutaneous LMWH can only be continued until the end of pregnancy.
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Study Notes
Pregnancy and Coagulation
- Pregnancy is associated with a hypercoagulable state.
Warfarin in Pregnancy
- Warfarin is associated with nasal hypoplasia and chondrodysplasia in the first trimester.
- Warfarin is linked to CNS abnormalities in late pregnancy.
- Warfarin use in pregnancy can lead to haemorrhagic complications.
- Warfarin is not recommended for use in pregnancy unless there are no other options.
Heparin in Pregnancy
- Heparin does not cross the placenta.
- Low molecular weight heparins (LMWH) are preferred due to better and more predictable pharmacokinetics.
- Subcutaneous LMWH can be continued throughout pregnancy and for the prothrombotic six weeks post partum.
Special Considerations
- Patients with prosthetic heart valves may require warfarin despite the risks to the fetus.
- Warfarin may be given up to 36 weeks in patients with prosthetic heart valves.
Pregnancy and Coagulation
- Pregnancy is associated with a hypercoagulable state.
Warfarin in Pregnancy
- Warfarin is associated with nasal hypoplasia and chondrodysplasia in the first trimester.
- Warfarin is linked to CNS abnormalities in late pregnancy.
- Warfarin use in pregnancy can lead to haemorrhagic complications.
- Warfarin is not recommended for use in pregnancy unless there are no other options.
Heparin in Pregnancy
- Heparin does not cross the placenta.
- Low molecular weight heparins (LMWH) are preferred due to better and more predictable pharmacokinetics.
- Subcutaneous LMWH can be continued throughout pregnancy and for the prothrombotic six weeks post partum.
Special Considerations
- Patients with prosthetic heart valves may require warfarin despite the risks to the fetus.
- Warfarin may be given up to 36 weeks in patients with prosthetic heart valves.
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