Podcast
Questions and Answers
What is the most sensitive index of heparin therapy and disseminated intravascular coagulation (DIC)?
What is the most sensitive index of heparin therapy and disseminated intravascular coagulation (DIC)?
Which pathway(s) does the activated partial thromboplastin time (aPTT) screen for abnormalities in?
Which pathway(s) does the activated partial thromboplastin time (aPTT) screen for abnormalities in?
Which laboratory test is most commonly used to monitor oral anticoagulant therapy?
Which laboratory test is most commonly used to monitor oral anticoagulant therapy?
How can it be determined if a patient has an inhibitor instead of a factor deficiency?
How can it be determined if a patient has an inhibitor instead of a factor deficiency?
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What does the bleeding time test measure?
What does the bleeding time test measure?
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Which test is the basic principle of the fibrinogen test most similar to?
Which test is the basic principle of the fibrinogen test most similar to?
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What is the name of the reagent used for performing the prothrombin time test?
What is the name of the reagent used for performing the prothrombin time test?
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Which coagulation disorder is often characterized by decreased aggregation with ristocetin?
Which coagulation disorder is often characterized by decreased aggregation with ristocetin?
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Which of the following tests are usually abnormal in hemophilia A?
Which of the following tests are usually abnormal in hemophilia A?
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Elevated fibrin split products (FSP's) can be seen in all of the following EXCEPT:
Elevated fibrin split products (FSP's) can be seen in all of the following EXCEPT:
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What is the name of the coagulation test that measures the time it takes for blood to clot?
What is the name of the coagulation test that measures the time it takes for blood to clot?
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Which of the following is NOT a coagulation test?
Which of the following is NOT a coagulation test?
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Study Notes
Coagulation Studies
- The most sensitive index of heparin therapy and DIC is the thrombin time.
- Activated partial thromboplastin time (aPTT) screens for abnormalities in intrinsic and common pathways.
- Prothrombin time (PT) is the most common laboratory test to monitor oral anticoagulant therapy.
Bleeding Time
- Bleeding time test measures platelet adhesion and aggregation on locally injured vascular subendothelium.
- Bleeding time is not affected by coagulation factor cascade or platelet quantity and quality.
Fibrinogen Test
- The basic principle of the fibrinogen test is similar to the thrombin time test.
Mixing Studies
- Mixing studies can help distinguish between a factor deficiency and an inhibitor.
- If PT and aPTT are corrected, it suggests a factor deficiency, whereas if they remain prolonged, it suggests an inhibitor.
Ristocetin-Induced Platelet Aggregation
- Decreased aggregation with ristocetin is often found in patients with von Willebrand's disease.
Hemophilia A
- In hemophilia A, aPTT, factor VIII level, and vWF:Ag are usually abnormal.
Fibrin Split Products (FSP's)
- Fibrin split products (FSP's) can be elevated in sepsis, pulmonary embolism, and extreme exercise, but not in factor VIII deficiency.
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Description
This quiz tests your knowledge on blood coagulation, anticoagulant therapy, and laboratory tests used to monitor them. Questions cover topics such as heparin therapy, DIC, and oral anticoagulant therapy.
