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Questions and Answers
Which type of heparin has a greater activity against factor Xa?
Which type of heparin has a greater activity against factor Xa?
- Low Molecular Weight Heparin (LMWH (correct)
- Warfarin
- Fondaparinux
- Unfractionated heparin
Which type of heparin has a more predictable anticoagulant response and does not require routine monitoring in most patients?
Which type of heparin has a more predictable anticoagulant response and does not require routine monitoring in most patients?
- Unfractionated heparin
- Low Molecular Weight Heparin (LMWH (correct)
- Warfarin
- Fondaparinux
Which type of heparin has a longer plasma half-life, allowing once or twice-daily administration?
Which type of heparin has a longer plasma half-life, allowing once or twice-daily administration?
- Fondaparinux
- Unfractionated heparin
- Low Molecular Weight Heparin (LMWH (correct)
- Warfarin
Which type of heparin has a lower risk of bleeding, HIT, and heparin-induced osteoporosis compared to UFH?
Which type of heparin has a lower risk of bleeding, HIT, and heparin-induced osteoporosis compared to UFH?
What type of inhibitor is Fondaparinux?
What type of inhibitor is Fondaparinux?
What does Warfarin inhibit the production of?
What does Warfarin inhibit the production of?
What influences the dose requirements of Warfarin?
What influences the dose requirements of Warfarin?
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Study Notes
- Low Molecular Weight Heparin (LMWH) is obtained by depolymerization of UFH and has greater activity against factor Xa.
- LMWHs have a more predictable anticoagulant response and do not require routine monitoring in most patients.
- LMWHs have a longer plasma half-life, allowing once or twice-daily administration.
- LMWHs have a lower risk of bleeding, HIT, and heparin-induced osteoporosis compared to UFH.
- Fondaparinux is an indirect inhibitor of factor Xa and has a predictable and linear dose-response relationship.
- Fondaparinux does not require routine coagulation monitoring or dose adjustments and has a long half-life.
- Warfarin has a narrow therapeutic index and requires frequent dose adjustments and patient monitoring.
- Warfarin inhibits the production of vitamin K-dependent coagulation factors and anticoagulant proteins.
- Warfarin dose requirements are influenced by various factors, including genetic variations, diet, and drug interactions.
- The dose of warfarin must be determined by frequent clinical and laboratory monitoring, and the initial dose must be overlapped with UFH or LMWHs.
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