17 Questions
Which drug is metabolized through N-dealkylation?
Caffeine
Which drug undergoes amine oxidation in its metabolism?
Epinephrine
Which of the following drugs is metabolized by S-oxidation?
Chlorpromazine
Which type of reaction is involved in the metabolism of aspirin?
Hydrolysis
In humans, which process significantly induces P450-mediated drug metabolism?
Amphetamine oxidation
What is the main function of Cytochrome P450s in xenobiotic metabolism?
Oxidation and dealkylation
Which enzyme is responsible for the addition of glucuronic acid in Phase II reactions of xenobiotic metabolism?
UDP-glucuronosyltransferases
What is the main purpose of Glutathione-S-transferases (GST) in drug metabolism?
Addition of glutathione
Which enzyme is NOT involved in Phase I reactions of xenobiotic metabolism?
Sulfotransferases (SULT)
What is the primary function of Alcohol Dehydrogenase in xenobiotic metabolism?
Reduction of alcohols
Which enzyme category is responsible for the addition of methyl groups to xenobiotics?
Methyltransferases
What is the main purpose of Phase II metabolism in xenobiotics?
Convert xenobiotics to more polar hydroxylated derivatives
Which drug metabolism reaction involves the conjugation with glutathione?
Glutathione conjugation
In alcohol metabolism, what system is responsible for increased activity in chronic alcoholism?
Microsomal ethanol oxidizing system (MEOS)
Which type of drug metabolism reaction involves the addition of a sulfate group?
Sulfation
What happens to xenobiotics during Phase II metabolism?
They become more water-soluble and polar
Which reaction type involves conjugating drugs with glucuronic acid in Phase II metabolism?
Glucuronidation
Test your knowledge about the enzymes involved in xenobiotic metabolism, including Phase I 'Oxygenases' such as Cytochrome P450s and Flavin-containing monooxygenases, as well as Phase II 'Transferase' enzymes like Sulfotransferases, UDP-glucuronosyltransferases, Glutathione-S-transferases, and N-acetyltransferases.
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