Xenobiotic Metabolizing Enzyme Reactions Quiz
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Questions and Answers

Which drug is metabolized through N-dealkylation?

  • Caffeine (correct)
  • Barbiturates
  • Ibuprofen
  • Amphetamines
  • Which drug undergoes amine oxidation in its metabolism?

  • Ethanol
  • Chloral hydrate
  • Clonazepam
  • Epinephrine (correct)
  • Which of the following drugs is metabolized by S-oxidation?

  • Nicotine
  • Acetaminophen
  • Chlorpromazine (correct)
  • Thioridazine
  • Which type of reaction is involved in the metabolism of aspirin?

    <p>Hydrolysis</p> Signup and view all the answers

    In humans, which process significantly induces P450-mediated drug metabolism?

    <p>Amphetamine oxidation</p> Signup and view all the answers

    What is the main function of Cytochrome P450s in xenobiotic metabolism?

    <p>Oxidation and dealkylation</p> Signup and view all the answers

    Which enzyme is responsible for the addition of glucuronic acid in Phase II reactions of xenobiotic metabolism?

    <p>UDP-glucuronosyltransferases</p> Signup and view all the answers

    What is the main purpose of Glutathione-S-transferases (GST) in drug metabolism?

    <p>Addition of glutathione</p> Signup and view all the answers

    Which enzyme is NOT involved in Phase I reactions of xenobiotic metabolism?

    <p>Sulfotransferases (SULT)</p> Signup and view all the answers

    What is the primary function of Alcohol Dehydrogenase in xenobiotic metabolism?

    <p>Reduction of alcohols</p> Signup and view all the answers

    Which enzyme category is responsible for the addition of methyl groups to xenobiotics?

    <p>Methyltransferases</p> Signup and view all the answers

    What is the main purpose of Phase II metabolism in xenobiotics?

    <p>Convert xenobiotics to more polar hydroxylated derivatives</p> Signup and view all the answers

    Which drug metabolism reaction involves the conjugation with glutathione?

    <p>Glutathione conjugation</p> Signup and view all the answers

    In alcohol metabolism, what system is responsible for increased activity in chronic alcoholism?

    <p>Microsomal ethanol oxidizing system (MEOS)</p> Signup and view all the answers

    Which type of drug metabolism reaction involves the addition of a sulfate group?

    <p>Sulfation</p> Signup and view all the answers

    What happens to xenobiotics during Phase II metabolism?

    <p>They become more water-soluble and polar</p> Signup and view all the answers

    Which reaction type involves conjugating drugs with glucuronic acid in Phase II metabolism?

    <p>Glucuronidation</p> Signup and view all the answers

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