Xenobiotic Metabolism
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Questions and Answers

Which organ predominantly carries out xenobiotic metabolism?

  • Intestine
  • Lungs
  • Liver (correct)
  • Kidney

What are the routes of secretion for xenobiotics?

  • Saliva, urine, breath, and sweat
  • Urine, feces, breath, and tears
  • Tears, saliva, urine, and sweat
  • Urine, feces, breath, and sweat (correct)

Which enzymes play a crucial role in xenobiotic metabolism?

  • Amylase enzymes
  • Cytochrome P450 enzymes (correct)
  • Protease enzymes
  • Lipase enzymes

Which of the following is the most frequent conjugation reaction in Phase 2 metabolism?

<p>Glucuronidation (A)</p> Signup and view all the answers

Which enzyme is responsible for mediating sulfation in Phase 2 metabolism?

<p>Sulfotransferases (C)</p> Signup and view all the answers

Which molecule is commonly used as the methyl donor in methylation reactions during Phase 2 metabolism?

<p>S-adenosylmethionine (D)</p> Signup and view all the answers

Which of the following organs contains the highest amount of cytochrome P450 enzymes?

<p>Liver (A)</p> Signup and view all the answers

What is the main function of cytochrome P450 enzymes?

<p>Produce steroid hormones (B)</p> Signup and view all the answers

Which of the following compounds can be metabolized by cytochrome P450 enzymes?

<p>Fatty acids (C)</p> Signup and view all the answers

Which enzyme is estimated to act on approximately 50% of known drugs?

<p>CYP3A4 (C)</p> Signup and view all the answers

What are some of the effects of cytochrome P450 in medicine?

<p>All of the above (D)</p> Signup and view all the answers

Which factors can affect xenobiotic metabolism?

<p>Age and sex (D)</p> Signup and view all the answers

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