12 Questions
Which organ predominantly carries out xenobiotic metabolism?
Liver
What are the routes of secretion for xenobiotics?
Urine, feces, breath, and sweat
Which enzymes play a crucial role in xenobiotic metabolism?
Cytochrome P450 enzymes
Which of the following is the most frequent conjugation reaction in Phase 2 metabolism?
Glucuronidation
Which enzyme is responsible for mediating sulfation in Phase 2 metabolism?
Sulfotransferases
Which molecule is commonly used as the methyl donor in methylation reactions during Phase 2 metabolism?
S-adenosylmethionine
Which of the following organs contains the highest amount of cytochrome P450 enzymes?
Liver
What is the main function of cytochrome P450 enzymes?
Produce steroid hormones
Which of the following compounds can be metabolized by cytochrome P450 enzymes?
Fatty acids
Which enzyme is estimated to act on approximately 50% of known drugs?
CYP3A4
What are some of the effects of cytochrome P450 in medicine?
All of the above
Which factors can affect xenobiotic metabolism?
Age and sex
Test your knowledge on xenobiotic metabolism and its role in deactivating and secreting compounds in the liver. Explore the different secretion routes for xenobiotics and the crucial role hepatic enzymes play in this process. Learn about the two phases of xenobiotic metabolism and the main reactions involved.
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