T1 L23: Demyelination disorders, 3/11/23, JY

What is primarily affected in Multiple Sclerosis?

Which term is used to describe the spread of lesions in Multiple Sclerosis?

What are the common signs that might be found in Multiple Sclerosis?

Which condition is not primarily associated with demyelination?

'Axonal' involvement is commonly associated with which neurological condition?

What is the common symptom associated with the spinal cord in multiple sclerosis?

Which investigation is used to demonstrate dissemination in time in multiple sclerosis?

What is the main focus of disease modifying therapies in multiple sclerosis?

Which symptom is commonly treated with muscle relaxants in multiple sclerosis?

What is the typical acute treatment for relapse in multiple sclerosis?

What does a positive oligoclonal bands test indicate in multiple sclerosis?

Multiple Sclerosis Overview

In Multiple Sclerosis (MS), the primary affected area is the Central Nervous System (CNS), specifically the myelin sheath covering nerve fibers.

Lesion Spread and Characteristics

The term "dissemination in space" is used to describe the spread of lesions in Multiple Sclerosis.

Common Signs and Symptoms

Common signs that might be found in Multiple Sclerosis include:
- Visual disturbances
- Muscle weakness
- Numbness or tingling
- Cognitive impairment
- Bladder and bowel dysfunction
- Fatigue

Demyelination Association

Guillain-Barré syndrome is a condition not primarily associated with demyelination.

Axonal Involvement

Axonal involvement is commonly associated with Multiple Sclerosis.

Spinal Cord Involvement

The common symptom associated with the spinal cord in Multiple Sclerosis is weakness or paralysis.

Diagnostic Investigations

Magnetic Resonance Imaging (MRI) is used to demonstrate dissemination in time in Multiple Sclerosis.

Disease Modifying Therapies

The main focus of disease modifying therapies in Multiple Sclerosis is to reduce the frequency and severity of relapses.

Symptom Management

Spasticity is commonly treated with muscle relaxants in Multiple Sclerosis.

Relapse Treatment

The typical acute treatment for relapse in Multiple Sclerosis is corticosteroids.

Oligoclonal Bands Test

A positive oligoclonal bands test indicates the presence of abnormal antibodies in the cerebrospinal fluid, supporting the diagnosis of Multiple Sclerosis.

This quiz module covers the key concepts of multiple sclerosis (MS) including demyelination, dissemination, investigations, treatments, and the nursing perspective. It also discusses the impact of demyelination on the peripheral and central nervous systems, as well as the role of inflammation and axonal damage in MS.