T1 SYMPOSIUM Demyelination disorders (JY)
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Questions and Answers

Which part of the brain is responsible for coordinating movement and maintaining balance?

  • Optic nerves
  • Cerebrum
  • Cerebellum (correct)
  • Brainstem
  • Which part of the central nervous system do the optic nerves belong to?

  • Cerebrum (correct)
  • Brainstem
  • Spinal cord
  • Cerebellum
  • What term is used to describe unsteadiness, often associated with damage to the cerebellum?

  • Weakness
  • Ataxia (correct)
  • Double vision
  • Numbness
  • Which part of the central nervous system is responsible for coordinating cranial nerves and can cause problems such as double vision and swallowing difficulties when affected?

    <p>Brainstem</p> Signup and view all the answers

    What is the term used to refer to the phenomenon of damaging the myelin sheaths in the peripheral nerves?

    <p>Demyelination</p> Signup and view all the answers

    What is the term used to refer to the phenomenon of damaging the axon itself in the peripheral nerves?

    <p>Axonal neuropathy</p> Signup and view all the answers

    Which term is used to describe neuropathies caused by toxic damage to the nerves, such as excessive alcohol consumption?

    <p>Axonal neuropathy</p> Signup and view all the answers

    What is the term used to describe the neuropathies that occur when the nerves are damaged and the myelin sheaths are affected?

    <p>Demyelinating neuropathy</p> Signup and view all the answers

    Which type of multiple sclerosis is characterized by a gradual accumulation of disability over time without relapses?

    <p>Primary progressive MS</p> Signup and view all the answers

    What is the term used to describe the spread of multiple sclerosis attacks in different parts of the body over time?

    <p>Dissemination</p> Signup and view all the answers

    Which type of multiple sclerosis is characterized by periods of relapses and remissions, with attacks followed by periods of recovery?

    <p>Relapsing-remitting MS</p> Signup and view all the answers

    What is the main concern for patients diagnosed with multiple sclerosis?

    <p>Accumulation of disability</p> Signup and view all the answers

    Which part of the central nervous system is affected by demyelination in multiple sclerosis?

    <p>Both the brain and the spinal cord</p> Signup and view all the answers

    Which type of neuropathy is the most common?

    <p>Axonal neuropathy</p> Signup and view all the answers

    What causes the body to attack the myelin sheets of the nerves in Guillain-Barre syndrome?

    <p>Autoimmune condition</p> Signup and view all the answers

    What is the main difference between demyelination in the peripheral nervous system and demyelination in the central nervous system?

    <p>The location of the nerves affected</p> Signup and view all the answers

    Which test can be used to collect the fluid that bathes the spinal cord and brain?

    <p>Lumbar puncture</p> Signup and view all the answers

    What are the typical constituents of the cerebrospinal fluid (CSF) in patients with multiple sclerosis (M.S.)?

    <p>Glucose and protein</p> Signup and view all the answers

    What do the presence of oligoclonal bands in the spinal fluid indicate?

    <p>A typical immune reaction in the brain</p> Signup and view all the answers

    What did the introduction of CT scans revolutionize for neurologists?

    <p>Ability to see inside the brain of a living person</p> Signup and view all the answers

    Which neurologist is credited with laying down some of the original descriptions of multiple sclerosis?

    <p>Charcot</p> Signup and view all the answers

    What is a key feature of multiple sclerosis that is used for diagnosis?

    <p>Inflammation in different parts of the central nervous system at different times</p> Signup and view all the answers

    Which part of the body did the pathologists draw pictures of patients with suspected multiple sclerosis in the mid-1800s?

    <p>Spinal cord</p> Signup and view all the answers

    What is the analogy used by the speaker to explain the scarring from inflammation in multiple sclerosis?

    <p>Getting a splinter underneath your skin</p> Signup and view all the answers

    Which imaging technique was used to visualize the air patterns in the brain?

    <p>EMI</p> Signup and view all the answers

    What did the air patterns in the brain indicate in patients with a brain tumor?

    <p>The location of the brain tumor</p> Signup and view all the answers

    What company made the first CT scanner?

    <p>EMI</p> Signup and view all the answers

    What type of images did the first EMI pictures provide?

    <p>Cross-sectional images of the brain</p> Signup and view all the answers

    What imaging technique came after CT scan?

    <p>MRI</p> Signup and view all the answers

    What was the main limitation of using air patterns to visualize the brain?

    <p>It didn't provide any pictures at all</p> Signup and view all the answers

    Which part of the central nervous system is responsible for coordinating movement and maintaining balance?

    <p>Cerebellum</p> Signup and view all the answers

    What is the term used to describe the spread of multiple sclerosis attacks in different parts of the body over time?

    <p>Dissemination in time and space</p> Signup and view all the answers

    Which test can be used to collect the fluid that bathes the spinal cord and brain?

    <p>Lumbar puncture</p> Signup and view all the answers

    What is the term used to describe the neuropathies that occur when the nerves are damaged and the myelin sheaths are affected?

    <p>Demyelination</p> Signup and view all the answers

    What is the main difference between demyelination in the peripheral nervous system and demyelination in the central nervous system?

    <p>Location of the demyelination</p> Signup and view all the answers

    What do the presence of oligoclonal bands in the spinal fluid indicate?

    <p>Synthesis of IgG in the CNS</p> Signup and view all the answers

    What imaging technique is used to demonstrate dissemination in time and space in multiple sclerosis?

    <p>MRI</p> Signup and view all the answers

    Which term is used to describe the damage to the myelin sheaths in the peripheral nerves?

    <p>Demyelination</p> Signup and view all the answers

    What areas of the central nervous system are affected by demyelination in multiple sclerosis?

    <p>Central nervous system</p> Signup and view all the answers

    What is the term used to describe the spread of multiple sclerosis attacks in different parts of the body over time?

    <p>Dissemination</p> Signup and view all the answers

    Which part of the central nervous system is responsible for coordinating cranial nerves and can cause problems such as double vision and swallowing difficulties when affected?

    <p>Brainstem</p> Signup and view all the answers

    What is the term used to describe the neuropathies that occur when the nerves are damaged and the myelin sheaths are affected?

    <p>Neuropathy</p> Signup and view all the answers

    What are the typical areas affected by multiple sclerosis?

    <p>Brain</p> Signup and view all the answers

    What is the term used to describe unsteadiness, often associated with damage to the cerebellum?

    <p>Ataxia</p> Signup and view all the answers

    Study Notes

    Brain Functions and Anatomy

    • The cerebellum coordinates movement and maintains balance.
    • Optic nerves belong to the central nervous system (CNS).
    • Ataxia describes unsteadiness often linked to cerebellum damage.
    • The brainstem coordinates cranial nerves; damage can result in double vision and swallowing issues.

    Neuropathy and Demyelination

    • Demyelination in peripheral nerves refers to damage to the myelin sheaths.
    • Axo-damage is the term for damage to the axon itself in peripheral nerves.
    • Toxic neuropathies result from nerve damage caused by toxins, such as alcohol abuse.
    • Demyelinating neuropathies occur when both the nerves and myelin sheaths are damaged.

    Multiple Sclerosis (MS)

    • Primary progressive multiple sclerosis is marked by gradual disability accumulation without relapses.
    • Dissemination in time describes the spreading of MS attacks in different body parts over time.
    • Relapsing-remitting multiple sclerosis features cycles of attacks and recovery periods.
    • Patients with MS are primarily concerned about progressive disability.
    • Demyelination in MS affects areas of the central nervous system, specifically the brain and spinal cord.
    • Peripheral neuropathy is the most common type of neuropathy.

    Guillain-Barre Syndrome

    • In Guillain-Barre syndrome, the body attacks the myelin sheaths of the nerves.

    Diagnosis and Testing

    • A lumbar puncture can collect cerebrospinal fluid (CSF) that bathes the spinal cord and brain.
    • Typical CSF constituents in MS patients include elevated protein levels and lymphocytes.
    • Oligoclonal bands in spinal fluid indicate immune activity or chronic inflammation.

    Imaging Techniques in Neurology

    • The introduction of CT scans revolutionized diagnostics for neurologists.
    • Thomas Willis is recognized for original descriptions of multiple sclerosis.
    • A key MS diagnostic feature is lesion distribution in the CNS.
    • Pathologists in the mid-1800s documented lesions in the central nervous system for suspected MS patients.
    • An analogy for scarring in MS compares it to "spots" on a map due to inflammation.
    • CT scans visualized air patterns in the brain, indicating tumors or other lesions.
    • The first CT scanner was developed by EMI.
    • The first EMI images provided cross-sectional views of the brain.
    • Following CT scans, MRI became the next major imaging technique.
    • Air pattern visualization had a limitation in resolving fine details.

    Repetition of Key Points

    • Both cerebellum and brainstem play critical roles in movement coordination.
    • Terminology related to the types of neuropathies and the specifics of multiple sclerosis is essential for understanding diagnostics and treatment.

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