Podcast
Questions and Answers
What type of mutation may result in the acquisition of a novel property by the mutant protein?
What type of mutation may result in the acquisition of a novel property by the mutant protein?
- Deletion mutation
- Insertion mutation
- Loss-of-function mutation
- Gain-of-function mutation (correct)
Which condition is caused by a loss of a chromosome?
Which condition is caused by a loss of a chromosome?
- Turner syndrome (correct)
- Fragile X syndrome
- α-thalassemia
- Trisomy 21
In Fragile X syndrome, decreased mRNA is caused by the silencing of which gene due to methylation?
In Fragile X syndrome, decreased mRNA is caused by the silencing of which gene due to methylation?
- βAPP gene
- α-globin gene
- PMP22 gene
- FMR1 gene (correct)
Which mutation locks hemoglobin in its high oxygen affinity state?
Which mutation locks hemoglobin in its high oxygen affinity state?
What is generally the cause of Trisomy 21?
What is generally the cause of Trisomy 21?
Which condition generally results from the duplication of peripheral myelin protein 22 (PMP22)?
Which condition generally results from the duplication of peripheral myelin protein 22 (PMP22)?
What is the novel property mutation exemplified by sickle cell disease?
What is the novel property mutation exemplified by sickle cell disease?
Which condition arises from mutations associated with heterochronic gene expression?
Which condition arises from mutations associated with heterochronic gene expression?
What is the primary reason for the benign nature of hereditary persistence of fetal hemoglobin?
What is the primary reason for the benign nature of hereditary persistence of fetal hemoglobin?
Which is an example of allelic heterogeneity?
Which is an example of allelic heterogeneity?
What distinguishes locus heterogeneity from allelic heterogeneity?
What distinguishes locus heterogeneity from allelic heterogeneity?
How does sickle hemoglobin differ from normal hemoglobin?
How does sickle hemoglobin differ from normal hemoglobin?
