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Questions and Answers
What is drug addiction?
What is drug addiction?
A severe form of substance use disorder characterized by compulsive drug seeking and use despite adverse consequences. It's considered a brain disorder due to functional changes in brain circuits that persist even after stopping drug use.
What are some examples of psychostimulants?
What are some examples of psychostimulants?
Nicotine, cocaine, methamphetamines, amphetamines, methylphenidate, and cathinone.
What is the defining feature of SUDs according to the DSM-5?
What is the defining feature of SUDs according to the DSM-5?
A cluster of cognitive, behavioral, and physiological symptoms.
What are the two main categories of hallucinogens?
What are the two main categories of hallucinogens?
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Which of the following is NOT a type of abused drug?
Which of the following is NOT a type of abused drug?
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The Schedule 1 DEA drugs have the lowest potential for abuse.
The Schedule 1 DEA drugs have the lowest potential for abuse.
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Which of the following is a defining feature of psychological addiction?
Which of the following is a defining feature of psychological addiction?
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Which of the following is NOT a mechanism of action for psychostimulants?
Which of the following is NOT a mechanism of action for psychostimulants?
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What is the primary mechanism of action of ethanol?
What is the primary mechanism of action of ethanol?
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Explain the mechanism of action of opioids.
Explain the mechanism of action of opioids.
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Describe the two main dopaminergic pathways linked to addiction.
Describe the two main dopaminergic pathways linked to addiction.
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What is the role of the ventral striatum in addiction?
What is the role of the ventral striatum in addiction?
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What is the role of the prefrontal cortex in addiction?
What is the role of the prefrontal cortex in addiction?
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What are the three steps of the addiction cycle?
What are the three steps of the addiction cycle?
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What brain region is primarily involved in the preoccupation/anticipation stage of the addiction cycle?
What brain region is primarily involved in the preoccupation/anticipation stage of the addiction cycle?
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What are the two sources of the negative state of withdrawal?
What are the two sources of the negative state of withdrawal?
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What is the dopamine depletion hypothesis of addiction?
What is the dopamine depletion hypothesis of addiction?
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Explain the difference between the 'GO' and 'STOP' systems in the prefrontal cortex.
Explain the difference between the 'GO' and 'STOP' systems in the prefrontal cortex.
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Describe the role of dopamine in the nucleus accumbens in the context of addiction.
Describe the role of dopamine in the nucleus accumbens in the context of addiction.
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What are the two main types of receptors present on medium spiny neurons (MSNs) in the nucleus accumbens?
What are the two main types of receptors present on medium spiny neurons (MSNs) in the nucleus accumbens?
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What is the difference in function between D1Rs and D2Rs in the NAc?
What is the difference in function between D1Rs and D2Rs in the NAc?
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How does dopamine signaling differ in response to natural reinforcers versus drugs of abuse?
How does dopamine signaling differ in response to natural reinforcers versus drugs of abuse?
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What is the purpose of the short access model in addiction research?
What is the purpose of the short access model in addiction research?
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What is the long access model used to model in addiction research?
What is the long access model used to model in addiction research?
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What is the purpose of the progressive ratio in addiction research?
What is the purpose of the progressive ratio in addiction research?
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What does the 'extinction-reinstatement' model of relapse test?
What does the 'extinction-reinstatement' model of relapse test?
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Describe the concept of 'compulsive drug seeking' and how it is modeled in animals.
Describe the concept of 'compulsive drug seeking' and how it is modeled in animals.
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What is a 'breakpoint' in the context of drug self-administration?
What is a 'breakpoint' in the context of drug self-administration?
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Drug addiction is a primary brain disorder that primarily affects the brain and not the body.
Drug addiction is a primary brain disorder that primarily affects the brain and not the body.
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Study Notes
Drug Addiction
- Severe biomedical disorder marked by compulsive substance use.
- Substance use disorders (SUDs) are characterized by actions repeated despite negative consequences.
- SUDs are classified as psychiatric disorders in the DSM and ICD.
- Intoxication involves changes in consciousness, cognition, perception, and behavior caused by drug use.
- Tolerance is a response to repeated drug use, requiring increasing amounts for the desired effect.
- Withdrawal involves unpleasant symptoms when stopping prolonged substance use.
- Physical dependence is tolerance to drug effects and withdrawal symptoms.
- Psychological dependence involves behaviors interfering with daily life.
- Physical addiction involves brain's adaptation to drug chemicals, seeking to alleviate withdrawal symptoms.
- Psychological addiction associates drug use with people, places, activities, and moods, leading to situational triggers for relapse.
- A defining feature of SUD is psychological addiction.
- Defining SUDs (DSM-5) include a cluster of cognitive, behavioral, and physiological symptoms.
- Drug addiction is a severe form of SUD, defined by compulsive use despite consequences, and is a brain disorder involving lasting changes in brain circuits.
- The DEA classifies substances based on abuse potential and medical use.
DEA Drug Schedules
- Schedule 1 drugs have the highest abuse potential and no recognized medical use.
- Schedule V drugs have the lowest abuse potential and accepted medical use with minimal risk of dependence.
Types of Abused Drugs
- Psychostimulants (e.g., nicotine, cocaine, amphetamines, methamphetamines, methylphenidate, cathinones).
- Hallucinogens (classic and dissociative).
- Entactogens (e.g., MDMA, MDA).
- Inhalants.
- Cannabis and synthetic cannabinoids.
- Depressants (e.g., ethanol, sedative-hypnotics, opioids).
Mechanisms of Action
- Psychostimulants: Nicotine, cocaine, amphetamines, methamphetamines affect dopamine, norepinephrine, and serotonin transporters or reverse their flow.
- Hallucinogens: Distort sensory perception.
- Entactogens: Increase empathy and sympathy, affecting dopamine, norepinephrine, and serotonin.
- Inhalants: Cause euphoria, dizziness, etc., and are highly dangerous.
- Cannabis: Produces euphoria, memory problems, and anxiety. Main compounds are CBD and THC.
- Depressants: Increase sedation. Ethanol blocks glutamate and increases GABA functioning. Opioids activate mu-opioid receptors. Benzodiazepines and barbiturates are GABA agonists.
Brain Regions in Addiction
- Dopaminergic pathways (mesolimbic and mesocortical) are critical reward pathways.
- Ventral tegmental area (VTA) sends dopamine to the nucleus accumbens (NAcc).
- NAcc is the pleasure center & is involved in approach toward reward.
- Dorsal striatum is related to habitual behavior.
- Amygdala is involved in associative learning and negative emotions.
- Extended amygdala (NAcc shell and central nucleus of amygdala) is involved in reward and negative emotions.
- Prefrontal cortex (PFC) regulates executive functions, goal-directed behavior, and inhibitory control.
Addiction Cycle
- Binge/intoxication: Substance use and its pleasurable effects.
- Withdrawal/negative affect: Negative emotional state after substance use.
- Preoccupation/anticipation: Seeking the substance again after abstinence.
Addiction Models
- Reward prediction error: Repeated substance use creates associations between reward and cues.
- Dopamine depletion: Repeated drug use can deplete dopamine, leading to motivation to use more to maintain some dopamine.
- Progressive ratio, extinction-reinstatement, and short/long access models are used to study addiction processes.
Stigma and Access to Care
- Stigma, fear of bias, and mistreatment can prevent individuals with SUD from seeking or receiving appropriate care.
- Health professionals' biases may impact quality of care.
- Limited access to health programs and reduced quality of care due to stigma.
- Stigma related to addiction reinforcing drug-seeking behavior.
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Description
This quiz explores the complexities of drug addiction, including its classification as a biomedical disorder and its impact on both physical and psychological health. Test your knowledge on substance use disorders, withdrawal symptoms, and the mechanisms of tolerance and dependence as they relate to addiction. Gain a deeper understanding of how addiction shapes behavior and cognition.