Understanding Cytokines
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Questions and Answers

Which of the following best describes the function of cytokines?

  • Reduction of enzyme activity
  • Regulation of cell production
  • Induction of immune response (correct)
  • Inhibition of cellular communication

What is the primary mechanism by which cytokines affect adjacent cells?

  • Endocrine system
  • Induction of transcriptional program
  • Paracrine mechanism (correct)
  • Autocrine mechanism

Which group of cytokines includes types I and II interferons?

  • Tumor necrosis factors (TNF)
  • Interleukins (IL)
  • Chemokines
  • Interferons (IFN) (correct)

What is the main impact of cytokine production due to inducing stimulus?

<p>Activation, proliferation, or differentiation of target cells (D)</p> Signup and view all the answers

Which feature characterizes the regulation of cytokine production?

<p>Tightly regulated with post-transcription/translational modifications (D)</p> Signup and view all the answers

How do cytokines primarily affect distant cells?

<p>Through activation of B and T cells (C)</p> Signup and view all the answers

What characterizes the behavior of the producing cell in the context of cytokine function?

<p>Binding cytokines to their own receptors through autocrine mechanism (A)</p> Signup and view all the answers

Which outcome can be a result of cytokine production due to inducing stimulus?

<p>Modulation of effector functions through transcriptional program (A)</p> Signup and view all the answers

What is the primary function of interleukins (IL) among cytokines?

<p>Induction of immune response (D)</p> Signup and view all the answers

What is a characteristic feature of interferons (IFN) among cytokines?

<p>Type I (IFN-a, b) and Type II (IFN-g) (C)</p> Signup and view all the answers

What is the effect of cytokine cascade induction?

<p>Production of additional cytokines by target cells (C)</p> Signup and view all the answers

What is a distinguishing feature of membrane-bound cytokines?

<p>They bind to receptors on producing cells through autocrine mechanism (A)</p> Signup and view all the answers

What is the main function of TNF-alpha?

<p>Stimulates the migration of innate cells (C)</p> Signup and view all the answers

Which characteristic is associated with pleiotropism in cytokines?

<p>They can be produced by multiple different cell types (B)</p> Signup and view all the answers

What is a common effect of systemic inflammation?

<p>Increased total body inflammation due to widespread presence of TNF-alpha (B)</p> Signup and view all the answers

Which cytokines are responsible for inducing the acute phase response?

<p>TNF-alpha, IL-1, and IL-6 (B)</p> Signup and view all the answers

Which characteristic is associated with chemokines?

<p>Stimulating migration of dendritic cells to lymph nodes (C)</p> Signup and view all the answers

What is the main distinguishing feature of local inflammation?

<p>Recruitment of cells to site of infection (A)</p> Signup and view all the answers

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