Anticancer Chemotherapy Drugs
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Anticancer Chemotherapy Drugs

Learn about different types of anticancer chemotherapy drugs, including antineoplastic antibiotics and antimetabolites, their mechanisms of action and examples.

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@PolitePlot

Questions and Answers

What is the mechanism of action of Antineoplastic Antibiotics?

Interacting with DNA, leading to strand breaks

Which of the following is an example of Antimetabolites?

Methotrexate

What is the mechanism of action of Alkylating Agents?

Donating alkyl groups to DNA, leading to DNA damage

Which of the following is an example of Antimicrotubules?

<p>Vinblastine</p> Signup and view all the answers

What is the mechanism of action of Topoisomerase Inhibitors?

<p>Inhibiting topoisomerase I or II</p> Signup and view all the answers

Which of the following is an example of Antineoplastic Antibiotics?

<p>Doxorubicin</p> Signup and view all the answers

How do Antimetabolites inhibit DNA synthesis?

<p>By mimicking nucleotide bases and inhibiting enzymes involved in nucleotide synthesis</p> Signup and view all the answers

Study Notes

Anticancer Chemotherapy Drugs

Antineoplastic Antibiotics

  • Derived from Streptomyces bacteria
  • Inhibit DNA synthesis by:
    • Interacting with DNA, leading to strand breaks
    • Inhibiting topoisomerase II
  • Examples:
    • Doxorubicin (Adriamycin)
    • Daunorubicin
    • Mitomycin
    • Bleomycin

Antimetabolites

  • Inhibit DNA synthesis by:
    • Mimicking nucleotide bases
    • Inhibiting enzymes involved in nucleotide synthesis
  • Examples:
    • Methotrexate (antifolate)
    • 5-Fluorouracil (5-FU)
    • Cytarabine (Ara-C)
    • Gemcitabine

Alkylating Agents

  • Inhibit DNA synthesis by:
    • Donating alkyl groups to DNA, leading to DNA damage
    • Forming cross-links between DNA strands
  • Examples:
    • Cyclophosphamide
    • Ifosfamide
    • Chlorambucil
    • Busulfan

Antimicrotubules

  • Inhibit mitosis by:
    • Inhibiting microtubule formation
    • Disrupting spindle fibers
  • Examples:
    • Vinblastine
    • Vincristine
    • Paclitaxel
    • Docetaxel

Topoisomerase Inhibitors

  • Inhibit DNA synthesis by:
    • Inhibiting topoisomerase I or II
    • Preventing DNA relaxation
  • Examples:
    • Topotecan (inhibits topoisomerase I)
    • Etoposide (inhibits topoisomerase II)
    • Irinotecan (inhibits topoisomerase I)

Anticancer Chemotherapy Drugs

Antineoplastic Antibiotics

  • Derived from Streptomyces bacteria
  • Inhibit DNA synthesis by interacting with DNA, leading to strand breaks
  • Inhibit topoisomerase II
  • Examples:
    • Doxorubicin (Adriamycin)
    • Daunorubicin
    • Mitomycin
    • Bleomycin

Antimetabolites

  • Inhibit DNA synthesis by mimicking nucleotide bases
  • Inhibit enzymes involved in nucleotide synthesis
  • Examples:
    • Methotrexate (antifolate)
    • 5-Fluorouracil (5-FU)
    • Cytarabine (Ara-C)
    • Gemcitabine

Alkylating Agents

  • Inhibit DNA synthesis by donating alkyl groups to DNA, leading to DNA damage
  • Form cross-links between DNA strands
  • Examples:
    • Cyclophosphamide
    • Ifosfamide
    • Chlorambucil
    • Busulfan

Antimicrotubules

  • Inhibit mitosis by inhibiting microtubule formation
  • Disrupt spindle fibers
  • Examples:
    • Vinblastine
    • Vincristine
    • Paclitaxel
    • Docetaxel

Topoisomerase Inhibitors

  • Inhibit DNA synthesis by inhibiting topoisomerase I or II
  • Prevent DNA relaxation
  • Examples:
    • Topotecan (inhibits topoisomerase I)
    • Etoposide (inhibits topoisomerase II)
    • Irinotecan (inhibits topoisomerase I)

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