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Questions and Answers
What is the mechanism of action of Antineoplastic Antibiotics?
What is the mechanism of action of Antineoplastic Antibiotics?
- Disrupting spindle fibers
- Inhibiting topoisomerase I
- Interacting with DNA, leading to strand breaks (correct)
- Mimicking nucleotide bases
Which of the following is an example of Antimetabolites?
Which of the following is an example of Antimetabolites?
- Doxorubicin
- Vinblastine
- Cyclophosphamide
- Methotrexate (correct)
What is the mechanism of action of Alkylating Agents?
What is the mechanism of action of Alkylating Agents?
- Donating alkyl groups to DNA, leading to DNA damage (correct)
- Disrupting spindle fibers
- Mimicking nucleotide bases
- Inhibiting topoisomerase II
Which of the following is an example of Antimicrotubules?
Which of the following is an example of Antimicrotubules?
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What is the mechanism of action of Topoisomerase Inhibitors?
What is the mechanism of action of Topoisomerase Inhibitors?
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Which of the following is an example of Antineoplastic Antibiotics?
Which of the following is an example of Antineoplastic Antibiotics?
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How do Antimetabolites inhibit DNA synthesis?
How do Antimetabolites inhibit DNA synthesis?
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Study Notes
Anticancer Chemotherapy Drugs
Antineoplastic Antibiotics
- Derived from Streptomyces bacteria
- Inhibit DNA synthesis by:
- Interacting with DNA, leading to strand breaks
- Inhibiting topoisomerase II
- Examples:
- Doxorubicin (Adriamycin)
- Daunorubicin
- Mitomycin
- Bleomycin
Antimetabolites
- Inhibit DNA synthesis by:
- Mimicking nucleotide bases
- Inhibiting enzymes involved in nucleotide synthesis
- Examples:
- Methotrexate (antifolate)
- 5-Fluorouracil (5-FU)
- Cytarabine (Ara-C)
- Gemcitabine
Alkylating Agents
- Inhibit DNA synthesis by:
- Donating alkyl groups to DNA, leading to DNA damage
- Forming cross-links between DNA strands
- Examples:
- Cyclophosphamide
- Ifosfamide
- Chlorambucil
- Busulfan
Antimicrotubules
- Inhibit mitosis by:
- Inhibiting microtubule formation
- Disrupting spindle fibers
- Examples:
- Vinblastine
- Vincristine
- Paclitaxel
- Docetaxel
Topoisomerase Inhibitors
- Inhibit DNA synthesis by:
- Inhibiting topoisomerase I or II
- Preventing DNA relaxation
- Examples:
- Topotecan (inhibits topoisomerase I)
- Etoposide (inhibits topoisomerase II)
- Irinotecan (inhibits topoisomerase I)
Anticancer Chemotherapy Drugs
Antineoplastic Antibiotics
- Derived from Streptomyces bacteria
- Inhibit DNA synthesis by interacting with DNA, leading to strand breaks
- Inhibit topoisomerase II
- Examples:
- Doxorubicin (Adriamycin)
- Daunorubicin
- Mitomycin
- Bleomycin
Antimetabolites
- Inhibit DNA synthesis by mimicking nucleotide bases
- Inhibit enzymes involved in nucleotide synthesis
- Examples:
- Methotrexate (antifolate)
- 5-Fluorouracil (5-FU)
- Cytarabine (Ara-C)
- Gemcitabine
Alkylating Agents
- Inhibit DNA synthesis by donating alkyl groups to DNA, leading to DNA damage
- Form cross-links between DNA strands
- Examples:
- Cyclophosphamide
- Ifosfamide
- Chlorambucil
- Busulfan
Antimicrotubules
- Inhibit mitosis by inhibiting microtubule formation
- Disrupt spindle fibers
- Examples:
- Vinblastine
- Vincristine
- Paclitaxel
- Docetaxel
Topoisomerase Inhibitors
- Inhibit DNA synthesis by inhibiting topoisomerase I or II
- Prevent DNA relaxation
- Examples:
- Topotecan (inhibits topoisomerase I)
- Etoposide (inhibits topoisomerase II)
- Irinotecan (inhibits topoisomerase I)
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Description
Learn about different types of anticancer chemotherapy drugs, including antineoplastic antibiotics and antimetabolites, their mechanisms of action and examples.
