7 Questions
What is the mechanism of action of Antineoplastic Antibiotics?
Interacting with DNA, leading to strand breaks
Which of the following is an example of Antimetabolites?
Methotrexate
What is the mechanism of action of Alkylating Agents?
Donating alkyl groups to DNA, leading to DNA damage
Which of the following is an example of Antimicrotubules?
Vinblastine
What is the mechanism of action of Topoisomerase Inhibitors?
Inhibiting topoisomerase I or II
Which of the following is an example of Antineoplastic Antibiotics?
Doxorubicin
How do Antimetabolites inhibit DNA synthesis?
By mimicking nucleotide bases and inhibiting enzymes involved in nucleotide synthesis
Study Notes
Anticancer Chemotherapy Drugs
Antineoplastic Antibiotics
- Derived from Streptomyces bacteria
- Inhibit DNA synthesis by:
- Interacting with DNA, leading to strand breaks
- Inhibiting topoisomerase II
- Examples:
- Doxorubicin (Adriamycin)
- Daunorubicin
- Mitomycin
- Bleomycin
Antimetabolites
- Inhibit DNA synthesis by:
- Mimicking nucleotide bases
- Inhibiting enzymes involved in nucleotide synthesis
- Examples:
- Methotrexate (antifolate)
- 5-Fluorouracil (5-FU)
- Cytarabine (Ara-C)
- Gemcitabine
Alkylating Agents
- Inhibit DNA synthesis by:
- Donating alkyl groups to DNA, leading to DNA damage
- Forming cross-links between DNA strands
- Examples:
- Cyclophosphamide
- Ifosfamide
- Chlorambucil
- Busulfan
Antimicrotubules
- Inhibit mitosis by:
- Inhibiting microtubule formation
- Disrupting spindle fibers
- Examples:
- Vinblastine
- Vincristine
- Paclitaxel
- Docetaxel
Topoisomerase Inhibitors
- Inhibit DNA synthesis by:
- Inhibiting topoisomerase I or II
- Preventing DNA relaxation
- Examples:
- Topotecan (inhibits topoisomerase I)
- Etoposide (inhibits topoisomerase II)
- Irinotecan (inhibits topoisomerase I)
Anticancer Chemotherapy Drugs
Antineoplastic Antibiotics
- Derived from Streptomyces bacteria
- Inhibit DNA synthesis by interacting with DNA, leading to strand breaks
- Inhibit topoisomerase II
- Examples:
- Doxorubicin (Adriamycin)
- Daunorubicin
- Mitomycin
- Bleomycin
Antimetabolites
- Inhibit DNA synthesis by mimicking nucleotide bases
- Inhibit enzymes involved in nucleotide synthesis
- Examples:
- Methotrexate (antifolate)
- 5-Fluorouracil (5-FU)
- Cytarabine (Ara-C)
- Gemcitabine
Alkylating Agents
- Inhibit DNA synthesis by donating alkyl groups to DNA, leading to DNA damage
- Form cross-links between DNA strands
- Examples:
- Cyclophosphamide
- Ifosfamide
- Chlorambucil
- Busulfan
Antimicrotubules
- Inhibit mitosis by inhibiting microtubule formation
- Disrupt spindle fibers
- Examples:
- Vinblastine
- Vincristine
- Paclitaxel
- Docetaxel
Topoisomerase Inhibitors
- Inhibit DNA synthesis by inhibiting topoisomerase I or II
- Prevent DNA relaxation
- Examples:
- Topotecan (inhibits topoisomerase I)
- Etoposide (inhibits topoisomerase II)
- Irinotecan (inhibits topoisomerase I)
Learn about different types of anticancer chemotherapy drugs, including antineoplastic antibiotics and antimetabolites, their mechanisms of action and examples.
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