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Questions and Answers
Questions and Answers
What is the primary characteristic of UBD?
What is the primary characteristic of UBD?
- Humoral immunity deficiency (correct)
- T-cell hyperactivity
- Cell-mediated immunity deficiency
- Bone marrow suppression
Which of the following is a common feature of UBD?
Which of the following is a common feature of UBD?
- Increased susceptibility to bacterial infections (correct)
- Excessive inflammatory response
- Abundant levels of Ig
- Enhanced T-cell function
What is the cause of deficiency seen in UBD?
What is the cause of deficiency seen in UBD?
- B cell defects (correct)
- Overproduction of antibodies
- Increased apoptosis in T cells
- Excessive Ig levels
What is a notable feature related to growth and development in UBD?
What is a notable feature related to growth and development in UBD?
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What is a pathogenesis factor of UBD?
What is a pathogenesis factor of UBD?
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Questions and Answers
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Study Notes
Study Notes
UBD Characteristics
- UBD is characterized by humoral immunity deficiency
- 50-60% of UBD cases involve B cell defects
- B cell defects lead to deficiency of Ig and antibody
Clinical Features
- Increased susceptibility to bacteria, enterovirus, and intestine parasites
- Delayed growth and development
- Increased incidence of autoimmune diseases
- Increased incidence of malignant tumors
- Reduced numbers of peripheral blood B cells
- Absent or reduced levels of Ig
Pathogenesis of UBD
- Block of differentiation and development of B cells
- Reduced function of Th cells
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