UBD: Humoral Immunity Deficiency

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Questions and Answers

What is the primary characteristic of UBD?

  • Humoral immunity deficiency (correct)
  • T-cell hyperactivity
  • Cell-mediated immunity deficiency
  • Bone marrow suppression

Which of the following is a common feature of UBD?

  • Increased susceptibility to bacterial infections (correct)
  • Excessive inflammatory response
  • Abundant levels of Ig
  • Enhanced T-cell function

What is the cause of deficiency seen in UBD?

  • B cell defects (correct)
  • Overproduction of antibodies
  • Increased apoptosis in T cells
  • Excessive Ig levels

What is a notable feature related to growth and development in UBD?

<p>Delayed growth and development (A)</p> Signup and view all the answers

What is a pathogenesis factor of UBD?

<p>Block of differentiation &amp; development of B cells (A)</p> Signup and view all the answers

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Study Notes

UBD Characteristics

  • UBD is characterized by humoral immunity deficiency
  • 50-60% of UBD cases involve B cell defects
  • B cell defects lead to deficiency of Ig and antibody

Clinical Features

  • Increased susceptibility to bacteria, enterovirus, and intestine parasites
  • Delayed growth and development
  • Increased incidence of autoimmune diseases
  • Increased incidence of malignant tumors
  • Reduced numbers of peripheral blood B cells
  • Absent or reduced levels of Ig

Pathogenesis of UBD

  • Block of differentiation and development of B cells
  • Reduced function of Th cells

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