Adrenergic Drugs - Hernandez - Block 2
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Questions and Answers

In order for Tyrosine to be made into Epinephrine, Amino acid decarboxylase changes DOPA into...?

  • Valine
  • Dopamine (correct)
  • Carboxylic acid
  • Norepinephrine

    • Match the Generic/Brand names

    Dobutamine = Dobutrex Naphazoline = Naphcon Oxymetazoline = Afrin Pseudoephedrine = Sudafed PE, Vazculep, Preparation H

    Match the Generic/Brand names

    Tetrahydrozoline = Visine Phenylephrine (oral) = Sudafed PE Phenylephrine (topical) = Preparation H Phenylephrine (IV) = Vazculep

    Match the Generic/Brand names

    <p>Brimonidine (ophthalmic) = Alphagan-P Clonidine = Kapvay, Catapres Guanfacine = Intuniv Isoproterenol = Isuprel</p> Signup and view all the answers

    Match the Generic/Brand names

    <p>Formoterol + Budesonide = Symbicort Fluticasone + Salmeterol = Advair Diskus, Advair HFA, AirDuo, RespiClick, Wixela Inhub Ipratropium + Albuterol = Combivent Respimat Mirabegron = Myrbetriq</p> Signup and view all the answers

    Match the Generic/Brand names

    <p>Carvedilol = Coreg Labetalol = Normodyne Propranolol = Inderal Atenolol = Tenormin</p> Signup and view all the answers

    Match the Generic/Brand names

    <p>Bisoprolol = Zebeta Metoprolol succinate = Toprol, Kapsargo Metoprolol tartrate = Lopressor Nebivolol = Bystolic</p> Signup and view all the answers

    Match the Generic/Brand names.

    <p>Epinephrine = Epipen, Primatene Mist Norepinephrine = Levophed Naphazoline = Clear Eyes Doxazosin = Cardura</p> Signup and view all the answers

    Match the Generic/Brand names.

    <p>Terazosin = Hytrin Tamsulosin = Flomax Albuterol = Proventil, Ventolin Levalbuterol = Xopenex</p> Signup and view all the answers

    The brand names for Timolol are: Betimol, Istalol, Timoptic

    <p>True</p> Signup and view all the answers

    What is the class for these drugs: Dobutamine, Epinephrine, Norepinephrine, and Pseudoephedrine?

    <p>Alpha and Beta Agonist</p> Signup and view all the answers

    What is the class for these drugs: Naphazoline, Oxymetazoline, and Tetrahydrozoline?

    <p>Non-selective Alpha 1/2 Agonist</p> Signup and view all the answers

    What drug class is Phenylephrine?

    <p>Alpha 1 Agonist</p> Signup and view all the answers

    Which class are the following drugs in: Briminodine, Clonidine, Guanfacine

    <p>Alpha 2 Agonist</p> Signup and view all the answers

    What is the class for these drugs: Doxazosin, Terazosin?

    <p>Non-selective Alpha 1A/1B/1D-Blockers</p> Signup and view all the answers

    Which class is Tamsulosin in?

    <p>Alpha 1A-selective Blockers</p> Signup and view all the answers

    What class is Propranolol in?

    <p>Non-selective Beta Blockers</p> Signup and view all the answers

    What class are these drugs in: Carvedilol, Labetalol?

    <p>Beta blockers with alpha blockade</p> Signup and view all the answers

    Timolol is in which drug class?

    <p>Ophthalmic Beta Blockers</p> Signup and view all the answers

    All of these drugs (Atenolol, Bisoprolol, Metoprolol succinate, Metoprolol tartrate, and Nebivolol) are in the "Beta 1 (Cardio-selective) Beta Blockers class?

    <p>True</p> Signup and view all the answers

    What drug class is Isoproterenol in?

    <p>Nonselective Beta (1/2) Agonist</p> Signup and view all the answers

    What class do these drugs go in: Albuterol, Levalbuterol?

    <p>Short-acting Beta 2 Agonists (SABA)</p> Signup and view all the answers

    What class is Mirabegron in?

    <p>Beta 3 Agonists</p> Signup and view all the answers

    NE, EPI, Increase heart rate, Promote sweating, Vasodilation, and Stimulate glucose release are all associated with the Sympathetic Nervous System?

    <p>True</p> Signup and view all the answers

    Maintain steady heart rate, Stimulate bile release, ACh, Miosis, and Maintain digestion are all associated with the Parasympathetic NS?

    <p>True</p> Signup and view all the answers

    What are the Neurotransmitters (Ligands) with the Adrenergic Synapse?

    <p>NE, EPI</p> Signup and view all the answers

    NE synthesis in the CNS and periphery:

    <p>CNS = Locus Coeruleus Periphery = Chromaffin Cells (Adrenal Glands) NE is converted to = EPI NE is converted to... by = PNMT</p> Signup and view all the answers

    Match the following functions:

    <p>a1 Agonists will = Increase BP and prostate tone a1 Blockers will = Decrease BP and prostate tone a2 Agonists will = Decrease BP, pain, consciousness, anxiety, CNS activity a2 Blockers will = Increase BP, pain, consciousness, anxiety, and CNS activity</p> Signup and view all the answers

    Match the following functions:

    <p>B1 Agonists will = Increase HR, Increase cardiac contractility B1 Blockers will = Decrease HR, Decrease cardiac contractility B2 Agonists will = Vasodilate (Lower BP), Sphincter relaxation, Promote contraction (motility) B2 Blockers will = Vasoconstrict (Raise BP), Sphincter constriction, Promote relaxation (halt motility)</p> Signup and view all the answers

    B3 Agonists will promote urinary retention, whereas B3 Blockers will promote urination?

    <p>True</p> Signup and view all the answers

    What is the Pharmacologic Class and MOA of Metyrosine?

    <p>Tyrosine hydroxylase inhibitor</p> Signup and view all the answers

    What is the Therapeutic Class of Metyrosine?

    <p>Cardiovascular Agent, drugs to treat Pheochromocytoma</p> Signup and view all the answers

    What is the Pharm. Action of Metyrosine?

    <p>Reduce catecholamine synthesis</p> Signup and view all the answers

    The indication for Metyrosine is Pheochromocytoma?

    <p>True</p> Signup and view all the answers

    What is an ADR for Metyrosine?

    <p>CNS/CV depression</p> Signup and view all the answers

    Which two drugs are AADC Substrates?

    <p>Methyldopa and Droxidopa</p> Signup and view all the answers

    Which of the following is NOT correct regarding Methyldopa?

    <p>It has a Black Box Warning of &quot;Supine hypertension&quot;</p> Signup and view all the answers

    Which of the following is NOT correct regarding Droxidopa?

    <p>Its AR are: CNS/CV depression</p> Signup and view all the answers

    What is the Therapeutic Class for Alpha-Beta Agonists?

    <p>Antiglaucoma Agents</p> Signup and view all the answers

    What Pharmacologic Class is Dipivefrin in?

    <p>Alpha-Beta Agonist</p> Signup and view all the answers

    What is the MOA of Dipivefrin?

    <p>Prodrug hydrolyzed to EPI</p> Signup and view all the answers

    What is the Pharm. Action of Dipivefrin?

    <p>Reduce intraocular pressure</p> Signup and view all the answers

    What is the indication for Dipivefrin?

    <p>Ocular hypertension, Glaucoma</p> Signup and view all the answers

    What is the metabolism of Dipivefrin?

    <p>MAO, COMT</p> Signup and view all the answers

    The ADR of Dipivefrin is minimal (due to metabolism by local enzymes) and CNS/CV stimulation if it enters systemic circulation?

    <p>True</p> Signup and view all the answers

    Alpha-beta Agonists and Beta Blockers (ophthalmic) are first line agents

    <p>False</p> Signup and view all the answers

    What is the therapeutic class of Timolol?

    <p>Antiglaucoma Agent</p> Signup and view all the answers

    What is the Pharmacologic Class of Timolol?

    <p>Beta Blockers (Ophthalmic)</p> Signup and view all the answers

    What is the MOA of Timolol?

    <p>Bind Beta 1 and Beta 2</p> Signup and view all the answers

    What is the Pharm. Action of Timolol?

    <p>Reduce intraocular pressure</p> Signup and view all the answers

    The indication AND ADR for Timolol (Ocular hypertension and Glaucoma) is the same as Dipivefrin?

    <p>True</p> Signup and view all the answers

    Dipivefrin is used for its beta-adrenergic receptor activity-aqueous humor

    <p>False</p> Signup and view all the answers

    The goal for Ophthalmic Adrenergic Drugs is to contract or relax any muscle that controls drainage or pupil diameter?

    <p>True</p> Signup and view all the answers

    What is the therapeutic class of Norepinephrine and Epinephrine?

    <p>CV Stimulants</p> Signup and view all the answers

    MOA of NE and EPI?

    <p>Alpha-Beta Agonist</p> Signup and view all the answers

    What is the Pharm. Action of NE and EPI?

    <p>Vasoconstriction and Increase inotropy</p> Signup and view all the answers

    The Metabolism of NE and EPI are MAO and COMT

    <p>True</p> Signup and view all the answers

    The indications for NE (usually to increase BP): Shock

    <p>True</p> Signup and view all the answers

    The indications for EPI (usually to increase inotropy): Bradycardia, Hypotensive shock, Cardiac arre.st, Anaphylaxis

    <p>True</p> Signup and view all the answers

    Which of the following is INCORRECT regarding NE and EPI (Alpha-Beta Agonists)?

    <p>Does cross the blood-brain barrier</p> Signup and view all the answers

    Which is an ADR for NE and EPI?

    <p>CNS and CV stimulation</p> Signup and view all the answers

    Which of the following is a BBB for NE ONLY?

    <p>Extravasation (Increased ischemia and necrosis risk)</p> Signup and view all the answers

    What Pharmacologic Class does Dobutamine belong in?

    <p>Alpha-Beta Agonist</p> Signup and view all the answers

    Match the following information about Dobutamine:

    <p>MOA = Major Beta 1 Agonist (Minor Alpha 1 and Beta 2 Agonist) Therapeutic Class = Positive Inotropic Agent and Vasoconstrictor Pharm. Action = Increase sympathetic outflow (but its specifically used for its actions on the heart) Indication = Acute treatment of low cardia output states</p> Signup and view all the answers

    Dobutamine's metabolism is : COMT substrate

    <p>True</p> Signup and view all the answers

    What is the Pharmacologic Class of Pseudoephedrine?

    <p>Alpha-Beta Agonist</p> Signup and view all the answers

    Match the following information on Pseudoephedrine:

    <p>MOA = Non-specific, Alpha-Beta Agonist (Alpha affinity &gt; Beta affinity, which is why it is used as a decongestant) Therapeutic Class = Decongestant Pharm. Action = Increase sympathetic outflow but it is specifically used for its actions: Nasal mucosa relaxation and Vasoconstriction to sinus vasculature Indication = Nasal Congestion</p> Signup and view all the answers

    Pseudoephedrine causes a false negative amphetamine urine test?

    <p>False</p> Signup and view all the answers

    Which of the following drugs is NOT a Non-selective Alpha 1/2 Agonist?

    <p>Antazoline</p> Signup and view all the answers

    Match the following information regarding Non-selective Alpha 1/2 Agonists.

    <p>Therapeutic Class = Vasoconstrictor, Decongestant Pharm. Action = Localized vasoconstriction and decongestion but used for its actions at alpha 1 receptors Clinical Use = Ocular hyperemia, Nasal congestion ADR = Ocular hypertension, localized irritation (Benzalkonium - CONTACT LENSES OUT!!)</p> Signup and view all the answers

    The ROA of Non-selective Alpha 1/2 Agonists is Topical (Ophthalmic, Nasal spray)

    <p>True</p> Signup and view all the answers

    What drug belongs in the Alpha 1-selective Agonist class?

    <p>Phenylephrine</p> Signup and view all the answers

    Match the following information regarding Phenylephrine:

    <p>Therapeutic Class = Vasoconstrictor, Decongestant Metabolism = MAO Drug-Drug Interaction = MAO Inhibitor, Any drug that targets alpha 1 adrenergic receptors Black Box Warning = Avoid extravasation, Must be administer by experienced clinician</p> Signup and view all the answers

    Phenylephrine's routes of administration determines its clinical use

    <p>True</p> Signup and view all the answers

    Do NOT use Alpha 1 Agonists with: Kids, anyone with Cardiovascular & Cerebrovascular disease, Urinary retention, Diabetes, and BHP

    <p>True</p> Signup and view all the answers

    Do NOT use Alpha Agonists with anyone: Breastfeeding, Has hypersensitivity to Phenylalanine & Sulfites, and with Contact Lenses

    <p>True</p> Signup and view all the answers

    Which two drugs are Alpha 2 Agonists?

    <p>Clonidine, Guanfacine</p> Signup and view all the answers

    Match the following information regarding Alpha 2 Agonists:

    <p>Therapeutic Class = Antihypertensive Pharm. Action = Reduce sympathetic outflow and Reduce blood pressure Indications = Hypertension Precautions &amp; Warnings = BEERS LIST, Avoid abrupt discontinuation, Pre-existing CV disease</p> Signup and view all the answers

    Which drug class does Brimonidine (Mirvaso) belong to?

    <p>Alpha 2 Agonist</p> Signup and view all the answers

    Match the following information regarding Brimonidine (Mirvaso):

    <p>Therapeutic Class = Dermatological Agent Pharm. Action = Promote localized vasoconstriction of subcutaneous blood vessels ROA = Topical Indication = Dermal, Facial erythema (Rosacea)</p> Signup and view all the answers

    Which of the following Pharm. Classes does Phentolamine and Phenoxybenzamine belong to?

    <p>Non-selective Alpha Blockers</p> Signup and view all the answers

    Match the following information regarding Non-selective Alpha Blockers:

    <p>MOA = Competitive, non-selective Alpha (Alpha 1 + Alpha 2) antagonist Pharm. Action = Reduce alpha-adrenergic-driven sympathetic outflow Indication = Pheochromocytoma, Antidote for extravasation of injectable drug with alpha agonist activity ADR = Hypotension, Nasal Congestion</p> Signup and view all the answers

    Match the following information regarding Non-selective Alpha Blockers

    <p>Phentolamine = Injectable for shorter procedures Phenoxybenzamine = Oral for symptomatic treatment Drug-Drug Interactions = Drug that targets alpha-adrenergic receptors, Antihypertensives ADR = Related to Vasodilation</p> Signup and view all the answers

    Match the following information regarding Alpha 1-selective Blockers:

    <p>Pharm: = Blocks actions of NE to promote smooth muscle. If it binds: Alpha 1A = In prostate, it will receive bladder outlet obstruction Alpha 1B = In vascular smooth it will lead to vasodilation Alpha 1D = In bladder neck, it will relieve bladder outlet resistance</p> Signup and view all the answers

    The MOA of Alpha 1-selective blocker is "Competitive Alpha 1-Adrenergic Antagonist"

    <p>True</p> Signup and view all the answers

    Tamsulosin binds to Alpha 1A in Prostate

    <p>True</p> Signup and view all the answers

    Which of the following drugs are Non-selective Alpha 1 Blockers?

    <p>Both B and C</p> Signup and view all the answers

    Which drug is an Alpha 1A-Selective Blocker?

    <p>Tamsulosin</p> Signup and view all the answers

    Match the following information regarding Alpha 1-selective Blockers

    <p>Beers Critera = Avoid in women with incontinence, Avoid to treat hypertension Contraindications = Angina, Hepatic impairment, Cataract Surgery, Advanced age ADR = Male sexual dysfunction Drug Interactions = Drugs that: Treat hypertension, Treat BPH, Substrate, inhibitor, or activator of CYP2D6 or CYP3A4</p> Signup and view all the answers

    Match the following subtypes and locations:

    <p>B2 = Lungs B3 = Bladder . = . B1 = Heart</p> Signup and view all the answers

    Which drug is a Beta 1/2 Agonist?

    <p>Isoproterenol</p> Signup and view all the answers

    Match the following information regarding Beta 1/2 Agonists:

    <p>Therapeutic Class = Positive Inotropic Agent Pharm. Action = Increase sympathetic outflow, Beta 1 activation: Increase heart rate and contractility Indication = Critically low cardiac output due to bradycardia and AV block Metabolism = COMT substrate</p> Signup and view all the answers

    The Beta 2 Agonists are: Short-acting and Less selective than the SABAs

    <p>True</p> Signup and view all the answers

    Which class/MOA is Metaproterenol?

    <p>Beta 2 Agonist</p> Signup and view all the answers

    Match the following information regarding Beta 2 Agonists:

    <p>Pharm. Action = Bronchodilation ROA = Oral tablet, solution, syrup, inhaled Indication = Acute bronchospasm ADR = CNS/CV stimulation</p> Signup and view all the answers

    Beta Blockers end with -OLOL

    <p>True</p> Signup and view all the answers

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