Adrenergic Drugs - Hernandez

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In order for Tyrosine to be made into Epinephrine, Amino acid decarboxylase changes DOPA into...?

Valine
Dopamine (correct)
Carboxylic acid
Norepinephrine

Match the Generic/Brand names

Dobutamine = Dobutrex Naphazoline = Naphcon Oxymetazoline = Afrin Pseudoephedrine = Sudafed PE, Vazculep, Preparation H

Match the Generic/Brand names

Tetrahydrozoline = Visine Phenylephrine (oral) = Sudafed PE Phenylephrine (topical) = Preparation H Phenylephrine (IV) = Vazculep

Match the Generic/Brand names

Brimonidine (ophthalmic) = Alphagan-P Clonidine = Kapvay, Catapres Guanfacine = Intuniv Isoproterenol = Isuprel Signup and view all the answers

Match the Generic/Brand names

Formoterol + Budesonide = Symbicort Fluticasone + Salmeterol = Advair Diskus, Advair HFA, AirDuo, RespiClick, Wixela Inhub Ipratropium + Albuterol = Combivent Respimat Mirabegron = Myrbetriq Signup and view all the answers

Match the Generic/Brand names

Carvedilol = Coreg Labetalol = Normodyne Propranolol = Inderal Atenolol = Tenormin Signup and view all the answers

Match the Generic/Brand names

Bisoprolol = Zebeta Metoprolol succinate = Toprol, Kapsargo Metoprolol tartrate = Lopressor Nebivolol = Bystolic Signup and view all the answers

Match the Generic/Brand names.

Epinephrine = Epipen, Primatene Mist Norepinephrine = Levophed Naphazoline = Clear Eyes Doxazosin = Cardura Signup and view all the answers

Match the Generic/Brand names.

Terazosin = Hytrin Tamsulosin = Flomax Albuterol = Proventil, Ventolin Levalbuterol = Xopenex Signup and view all the answers

The brand names for Timolol are: Betimol, Istalol, Timoptic

True (A) Signup and view all the answers

What is the class for these drugs: Dobutamine, Epinephrine, Norepinephrine, and Pseudoephedrine?

Alpha and Beta Agonist (B) Signup and view all the answers

What is the class for these drugs: Naphazoline, Oxymetazoline, and Tetrahydrozoline?

Non-selective Alpha 1/2 Agonist (A) Signup and view all the answers

What drug class is Phenylephrine?

Alpha 1 Agonist (B) Signup and view all the answers

Which class are the following drugs in: Briminodine, Clonidine, Guanfacine

Alpha 2 Agonist (D) Signup and view all the answers

What is the class for these drugs: Doxazosin, Terazosin?

Non-selective Alpha 1A/1B/1D-Blockers (A) Signup and view all the answers

Which class is Tamsulosin in?

Alpha 1A-selective Blockers (C) Signup and view all the answers

What class is Propranolol in?

Non-selective Beta Blockers (A) Signup and view all the answers

What class are these drugs in: Carvedilol, Labetalol?

Beta blockers with alpha blockade (C) Signup and view all the answers

Timolol is in which drug class?

Ophthalmic Beta Blockers (B) Signup and view all the answers

All of these drugs (Atenolol, Bisoprolol, Metoprolol succinate, Metoprolol tartrate, and Nebivolol) are in the "Beta 1 (Cardio-selective) Beta Blockers class?

True (A) Signup and view all the answers

What drug class is Isoproterenol in?

Nonselective Beta (1/2) Agonist (D) Signup and view all the answers

What class do these drugs go in: Albuterol, Levalbuterol?

Short-acting Beta 2 Agonists (SABA) (A) Signup and view all the answers

What class is Mirabegron in?

Beta 3 Agonists (C) Signup and view all the answers

NE, EPI, Increase heart rate, Promote sweating, Vasodilation, and Stimulate glucose release are all associated with the Sympathetic Nervous System?

True (A) Signup and view all the answers

Maintain steady heart rate, Stimulate bile release, ACh, Miosis, and Maintain digestion are all associated with the Parasympathetic NS?

True (A) Signup and view all the answers

What are the Neurotransmitters (Ligands) with the Adrenergic Synapse?

NE, EPI (A) Signup and view all the answers

NE synthesis in the CNS and periphery:

CNS = Locus Coeruleus Periphery = Chromaffin Cells (Adrenal Glands) NE is converted to = EPI NE is converted to... by = PNMT Signup and view all the answers

Match the following functions:

a1 Agonists will = Increase BP and prostate tone a1 Blockers will = Decrease BP and prostate tone a2 Agonists will = Decrease BP, pain, consciousness, anxiety, CNS activity a2 Blockers will = Increase BP, pain, consciousness, anxiety, and CNS activity Signup and view all the answers

Match the following functions:

B1 Agonists will = Increase HR, Increase cardiac contractility B1 Blockers will = Decrease HR, Decrease cardiac contractility B2 Agonists will = Vasodilate (Lower BP), Sphincter relaxation, Promote contraction (motility) B2 Blockers will = Vasoconstrict (Raise BP), Sphincter constriction, Promote relaxation (halt motility) Signup and view all the answers

B3 Agonists will promote urinary retention, whereas B3 Blockers will promote urination?

True (A) Signup and view all the answers

What is the Pharmacologic Class and MOA of Metyrosine?

Tyrosine hydroxylase inhibitor (B) Signup and view all the answers

What is the Therapeutic Class of Metyrosine?

Cardiovascular Agent, drugs to treat Pheochromocytoma (C) Signup and view all the answers

What is the Pharm. Action of Metyrosine?

Reduce catecholamine synthesis (B) Signup and view all the answers

The indication for Metyrosine is Pheochromocytoma?

True (A) Signup and view all the answers

What is an ADR for Metyrosine?

CNS/CV depression (D) Signup and view all the answers

Which two drugs are AADC Substrates?

Methyldopa and Droxidopa (A) Signup and view all the answers

Which of the following is NOT correct regarding Methyldopa?

It has a Black Box Warning of "Supine hypertension" (C) Signup and view all the answers

Which of the following is NOT correct regarding Droxidopa?

Its AR are: CNS/CV depression (A) Signup and view all the answers

What is the Therapeutic Class for Alpha-Beta Agonists?

Antiglaucoma Agents (C) Signup and view all the answers

What Pharmacologic Class is Dipivefrin in?

Alpha-Beta Agonist (B) Signup and view all the answers

What is the MOA of Dipivefrin?

Prodrug hydrolyzed to EPI (A) Signup and view all the answers

What is the Pharm. Action of Dipivefrin?

Reduce intraocular pressure (B) Signup and view all the answers

What is the indication for Dipivefrin?

Ocular hypertension, Glaucoma (B) Signup and view all the answers

What is the metabolism of Dipivefrin?

MAO, COMT (A) Signup and view all the answers

The ADR of Dipivefrin is minimal (due to metabolism by local enzymes) and CNS/CV stimulation if it enters systemic circulation?

True (A) Signup and view all the answers

Alpha-beta Agonists and Beta Blockers (ophthalmic) are first line agents

False (B) Signup and view all the answers

What is the therapeutic class of Timolol?

Antiglaucoma Agent (C) Signup and view all the answers

What is the Pharmacologic Class of Timolol?

Beta Blockers (Ophthalmic) (A) Signup and view all the answers

What is the MOA of Timolol?

Bind Beta 1 and Beta 2 (D) Signup and view all the answers

What is the Pharm. Action of Timolol?

Reduce intraocular pressure (C) Signup and view all the answers

The indication AND ADR for Timolol (Ocular hypertension and Glaucoma) is the same as Dipivefrin?

True (A) Signup and view all the answers

Dipivefrin is used for its beta-adrenergic receptor activity-aqueous humor

False (B) Signup and view all the answers

The goal for Ophthalmic Adrenergic Drugs is to contract or relax any muscle that controls drainage or pupil diameter?

True (A) Signup and view all the answers

What is the therapeutic class of Norepinephrine and Epinephrine?

CV Stimulants (B) Signup and view all the answers

MOA of NE and EPI?

Alpha-Beta Agonist (A) Signup and view all the answers

What is the Pharm. Action of NE and EPI?

Vasoconstriction and Increase inotropy (C) Signup and view all the answers

The Metabolism of NE and EPI are MAO and COMT

True (A) Signup and view all the answers

The indications for NE (usually to increase BP): Shock

True (A) Signup and view all the answers

The indications for EPI (usually to increase inotropy): Bradycardia, Hypotensive shock, Cardiac arre.st, Anaphylaxis

True (A) Signup and view all the answers

Which of the following is INCORRECT regarding NE and EPI (Alpha-Beta Agonists)?

Does cross the blood-brain barrier (C) Signup and view all the answers

Which is an ADR for NE and EPI?

CNS and CV stimulation (A) Signup and view all the answers

Which of the following is a BBB for NE ONLY?

Extravasation (Increased ischemia and necrosis risk) (D) Signup and view all the answers

What Pharmacologic Class does Dobutamine belong in?

Alpha-Beta Agonist (B) Signup and view all the answers

Match the following information about Dobutamine:

MOA = Major Beta 1 Agonist (Minor Alpha 1 and Beta 2 Agonist) Therapeutic Class = Positive Inotropic Agent and Vasoconstrictor Pharm. Action = Increase sympathetic outflow (but its specifically used for its actions on the heart) Indication = Acute treatment of low cardia output states Signup and view all the answers

Dobutamine's metabolism is : COMT substrate

True (A) Signup and view all the answers

What is the Pharmacologic Class of Pseudoephedrine?

Alpha-Beta Agonist (C) Signup and view all the answers

Match the following information on Pseudoephedrine:

MOA = Non-specific, Alpha-Beta Agonist (Alpha affinity > Beta affinity, which is why it is used as a decongestant) Therapeutic Class = Decongestant Pharm. Action = Increase sympathetic outflow but it is specifically used for its actions: Nasal mucosa relaxation and Vasoconstriction to sinus vasculature Indication = Nasal Congestion Signup and view all the answers

Pseudoephedrine causes a false negative amphetamine urine test?

False (B) Signup and view all the answers

Which of the following drugs is NOT a Non-selective Alpha 1/2 Agonist?

Antazoline (B) Signup and view all the answers

Match the following information regarding Non-selective Alpha 1/2 Agonists.

Therapeutic Class = Vasoconstrictor, Decongestant Pharm. Action = Localized vasoconstriction and decongestion but used for its actions at alpha 1 receptors Clinical Use = Ocular hyperemia, Nasal congestion ADR = Ocular hypertension, localized irritation (Benzalkonium - CONTACT LENSES OUT!!) Signup and view all the answers

The ROA of Non-selective Alpha 1/2 Agonists is Topical (Ophthalmic, Nasal spray)

True (A) Signup and view all the answers

What drug belongs in the Alpha 1-selective Agonist class?

Phenylephrine (D) Signup and view all the answers

Match the following information regarding Phenylephrine:

Therapeutic Class = Vasoconstrictor, Decongestant Metabolism = MAO Drug-Drug Interaction = MAO Inhibitor, Any drug that targets alpha 1 adrenergic receptors Black Box Warning = Avoid extravasation, Must be administer by experienced clinician Signup and view all the answers

Phenylephrine's routes of administration determines its clinical use

True (A) Signup and view all the answers

Do NOT use Alpha 1 Agonists with: Kids, anyone with Cardiovascular & Cerebrovascular disease, Urinary retention, Diabetes, and BHP

True (A) Signup and view all the answers

Do NOT use Alpha Agonists with anyone: Breastfeeding, Has hypersensitivity to Phenylalanine & Sulfites, and with Contact Lenses

True (A) Signup and view all the answers

Which two drugs are Alpha 2 Agonists?

Clonidine, Guanfacine (B) Signup and view all the answers

Match the following information regarding Alpha 2 Agonists:

Therapeutic Class = Antihypertensive Pharm. Action = Reduce sympathetic outflow and Reduce blood pressure Indications = Hypertension Precautions & Warnings = BEERS LIST, Avoid abrupt discontinuation, Pre-existing CV disease Signup and view all the answers

Which drug class does Brimonidine (Mirvaso) belong to?

Alpha 2 Agonist (B) Signup and view all the answers

Match the following information regarding Brimonidine (Mirvaso):

Therapeutic Class = Dermatological Agent Pharm. Action = Promote localized vasoconstriction of subcutaneous blood vessels ROA = Topical Indication = Dermal, Facial erythema (Rosacea) Signup and view all the answers

Which of the following Pharm. Classes does Phentolamine and Phenoxybenzamine belong to?

Non-selective Alpha Blockers (D) Signup and view all the answers

Match the following information regarding Non-selective Alpha Blockers:

MOA = Competitive, non-selective Alpha (Alpha 1 + Alpha 2) antagonist Pharm. Action = Reduce alpha-adrenergic-driven sympathetic outflow Indication = Pheochromocytoma, Antidote for extravasation of injectable drug with alpha agonist activity ADR = Hypotension, Nasal Congestion Signup and view all the answers

Match the following information regarding Non-selective Alpha Blockers

Phentolamine = Injectable for shorter procedures Phenoxybenzamine = Oral for symptomatic treatment Drug-Drug Interactions = Drug that targets alpha-adrenergic receptors, Antihypertensives ADR = Related to Vasodilation Signup and view all the answers

Match the following information regarding Alpha 1-selective Blockers:

Pharm: = Blocks actions of NE to promote smooth muscle. If it binds: Alpha 1A = In prostate, it will receive bladder outlet obstruction Alpha 1B = In vascular smooth it will lead to vasodilation Alpha 1D = In bladder neck, it will relieve bladder outlet resistance Signup and view all the answers

The MOA of Alpha 1-selective blocker is "Competitive Alpha 1-Adrenergic Antagonist"

True (A) Signup and view all the answers

Tamsulosin binds to Alpha 1A in Prostate

True (A) Signup and view all the answers

Which of the following drugs are Non-selective Alpha 1 Blockers?

Both B and C (D) Signup and view all the answers

Which drug is an Alpha 1A-Selective Blocker?

Tamsulosin (A) Signup and view all the answers

Match the following information regarding Alpha 1-selective Blockers

Beers Critera = Avoid in women with incontinence, Avoid to treat hypertension Contraindications = Angina, Hepatic impairment, Cataract Surgery, Advanced age ADR = Male sexual dysfunction Drug Interactions = Drugs that: Treat hypertension, Treat BPH, Substrate, inhibitor, or activator of CYP2D6 or CYP3A4 Signup and view all the answers

Match the following subtypes and locations:

B2 = Lungs B3 = Bladder . = . B1 = Heart Signup and view all the answers

Which drug is a Beta 1/2 Agonist?

Isoproterenol (C) Signup and view all the answers

Match the following information regarding Beta 1/2 Agonists:

Therapeutic Class = Positive Inotropic Agent Pharm. Action = Increase sympathetic outflow, Beta 1 activation: Increase heart rate and contractility Indication = Critically low cardiac output due to bradycardia and AV block Metabolism = COMT substrate Signup and view all the answers

The Beta 2 Agonists are: Short-acting and Less selective than the SABAs

True (A) Signup and view all the answers

Which class/MOA is Metaproterenol?

Beta 2 Agonist (B) Signup and view all the answers

Match the following information regarding Beta 2 Agonists:

Pharm. Action = Bronchodilation ROA = Oral tablet, solution, syrup, inhaled Indication = Acute bronchospasm ADR = CNS/CV stimulation Signup and view all the answers

Beta Blockers end with -OLOL

True (A) Signup and view all the answers

Adrenergic Drugs - Hernandez - Block 2

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Questions and Answers

In order for Tyrosine to be made into Epinephrine, Amino acid decarboxylase changes DOPA into...?

Match the Generic/Brand names

Match the Generic/Brand names

Match the Generic/Brand names

Match the Generic/Brand names

Match the Generic/Brand names

Match the Generic/Brand names

Match the Generic/Brand names.

Match the Generic/Brand names.

The brand names for Timolol are: Betimol, Istalol, Timoptic

What is the class for these drugs: Dobutamine, Epinephrine, Norepinephrine, and Pseudoephedrine?

What is the class for these drugs: Naphazoline, Oxymetazoline, and Tetrahydrozoline?

What drug class is Phenylephrine?

Which class are the following drugs in: Briminodine, Clonidine, Guanfacine

What is the class for these drugs: Doxazosin, Terazosin?

Which class is Tamsulosin in?

What class is Propranolol in?

What class are these drugs in: Carvedilol, Labetalol?

Timolol is in which drug class?

All of these drugs (Atenolol, Bisoprolol, Metoprolol succinate, Metoprolol tartrate, and Nebivolol) are in the "Beta 1 (Cardio-selective) Beta Blockers class?

What drug class is Isoproterenol in?

What class do these drugs go in: Albuterol, Levalbuterol?

What class is Mirabegron in?

NE, EPI, Increase heart rate, Promote sweating, Vasodilation, and Stimulate glucose release are all associated with the Sympathetic Nervous System?

Maintain steady heart rate, Stimulate bile release, ACh, Miosis, and Maintain digestion are all associated with the Parasympathetic NS?

What are the Neurotransmitters (Ligands) with the Adrenergic Synapse?

NE synthesis in the CNS and periphery:

Match the following functions:

Match the following functions:

B3 Agonists will promote urinary retention, whereas B3 Blockers will promote urination?

What is the Pharmacologic Class and MOA of Metyrosine?

What is the Therapeutic Class of Metyrosine?

What is the Pharm. Action of Metyrosine?

The indication for Metyrosine is Pheochromocytoma?

What is an ADR for Metyrosine?

Which two drugs are AADC Substrates?

Which of the following is NOT correct regarding Methyldopa?

Which of the following is NOT correct regarding Droxidopa?

What is the Therapeutic Class for Alpha-Beta Agonists?

What Pharmacologic Class is Dipivefrin in?

What is the MOA of Dipivefrin?

What is the Pharm. Action of Dipivefrin?

What is the indication for Dipivefrin?

What is the metabolism of Dipivefrin?

The ADR of Dipivefrin is minimal (due to metabolism by local enzymes) and CNS/CV stimulation if it enters systemic circulation?

Alpha-beta Agonists and Beta Blockers (ophthalmic) are first line agents

What is the therapeutic class of Timolol?

What is the Pharmacologic Class of Timolol?

What is the MOA of Timolol?

What is the Pharm. Action of Timolol?

The indication AND ADR for Timolol (Ocular hypertension and Glaucoma) is the same as Dipivefrin?

Dipivefrin is used for its beta-adrenergic receptor activity-aqueous humor

The goal for Ophthalmic Adrenergic Drugs is to contract or relax any muscle that controls drainage or pupil diameter?

What is the therapeutic class of Norepinephrine and Epinephrine?

MOA of NE and EPI?

What is the Pharm. Action of NE and EPI?

The Metabolism of NE and EPI are MAO and COMT

The indications for NE (usually to increase BP): Shock

The indications for EPI (usually to increase inotropy): Bradycardia, Hypotensive shock, Cardiac arre.st, Anaphylaxis

Which of the following is INCORRECT regarding NE and EPI (Alpha-Beta Agonists)?

Which is an ADR for NE and EPI?

Which of the following is a BBB for NE ONLY?

What Pharmacologic Class does Dobutamine belong in?

Match the following information about Dobutamine:

Dobutamine's metabolism is : COMT substrate

What is the Pharmacologic Class of Pseudoephedrine?

Match the following information on Pseudoephedrine:

Pseudoephedrine causes a false negative amphetamine urine test?

Which of the following drugs is NOT a Non-selective Alpha 1/2 Agonist?

Match the following information regarding Non-selective Alpha 1/2 Agonists.

The ROA of Non-selective Alpha 1/2 Agonists is Topical (Ophthalmic, Nasal spray)

What drug belongs in the Alpha 1-selective Agonist class?

Match the following information regarding Phenylephrine:

Phenylephrine's routes of administration determines its clinical use

Do NOT use Alpha 1 Agonists with: Kids, anyone with Cardiovascular & Cerebrovascular disease, Urinary retention, Diabetes, and BHP

Do NOT use Alpha Agonists with anyone: Breastfeeding, Has hypersensitivity to Phenylalanine & Sulfites, and with Contact Lenses