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Questions and Answers
Which type of seizures typically results in a brief lapse of awareness without loss of posture?
Which type of seizures typically results in a brief lapse of awareness without loss of posture?
- Focal onset seizures
- Myoclonic seizures
- Absence seizures (correct)
- Tonic-clonic seizures
What is a common adverse effect of both carbamazepine and oxcarbazepine?
What is a common adverse effect of both carbamazepine and oxcarbazepine?
- Hyponatremia (correct)
- Gingival hyperplasia
- Respiratory depression
- Weight gain
Which medication is considered first line for treating absence seizures?
Which medication is considered first line for treating absence seizures?
- Oxcarbazepine
- Ethosuximide (correct)
- Gabapentin
- Lamotrigine
What is the mechanism of action of phenytoin in the treatment of seizures?
What is the mechanism of action of phenytoin in the treatment of seizures?
What adverse effect is specifically associated with lamotrigine?
What adverse effect is specifically associated with lamotrigine?
Which seizure type is characterized by a rapid loss of muscle tone?
Which seizure type is characterized by a rapid loss of muscle tone?
What is a notable adverse effect of benzodiazepines when suddenly withdrawn?
What is a notable adverse effect of benzodiazepines when suddenly withdrawn?
Which medication has a mechanism of action unrelated to GABA, despite its name?
Which medication has a mechanism of action unrelated to GABA, despite its name?
Phenytoin is particularly effective for which type of seizures?
Phenytoin is particularly effective for which type of seizures?
What is a significant adverse effect of valproic acid?
What is a significant adverse effect of valproic acid?
What is a primary action of calcium (Ca+) channel blockers in the treatment of seizures?
What is a primary action of calcium (Ca+) channel blockers in the treatment of seizures?
Which medication is noted for having a mechanism of action that includes inhibiting voltage-gated Na+ channels?
Which medication is noted for having a mechanism of action that includes inhibiting voltage-gated Na+ channels?
What is a severe potential adverse effect associated with carbamazepine?
What is a severe potential adverse effect associated with carbamazepine?
Why is it important to treat the cause of seizures?
Why is it important to treat the cause of seizures?
What characterizes generalized onset seizures as more problematic than focal onset seizures?
What characterizes generalized onset seizures as more problematic than focal onset seizures?
What is a characteristic adverse effect of lamotrigine?
What is a characteristic adverse effect of lamotrigine?
What effect does phenytoin have at therapeutic doses?
What effect does phenytoin have at therapeutic doses?
Which of the following drugs is primarily used to manage absence seizures?
Which of the following drugs is primarily used to manage absence seizures?
What is a common side effect of benzodiazepines when used for managing status epilepticus?
What is a common side effect of benzodiazepines when used for managing status epilepticus?
What side effect is associated with long-term use of gabapentin?
What side effect is associated with long-term use of gabapentin?
What is the primary effect of blocking Na+ channels in the treatment of seizures?
What is the primary effect of blocking Na+ channels in the treatment of seizures?
Which medication is known to have higher risks for hyponatremia among antiepileptics?
Which medication is known to have higher risks for hyponatremia among antiepileptics?
What is a potential consequence of abruptly stopping benzodiazepines in patients with epilepsy?
What is a potential consequence of abruptly stopping benzodiazepines in patients with epilepsy?
Which adverse effect is associated with lamotrigine?
Which adverse effect is associated with lamotrigine?
What characterizes focal onset seizures compared to generalized onset seizures?
What characterizes focal onset seizures compared to generalized onset seizures?
Which of the following medications is utilized for a broad range of seizure types, including generalized and myoclonic seizures?
Which of the following medications is utilized for a broad range of seizure types, including generalized and myoclonic seizures?
What is a characteristic feature of absence seizures?
What is a characteristic feature of absence seizures?
What is a notable adverse effect of the drug gabapentin?
What is a notable adverse effect of the drug gabapentin?
What role do calcium (Ca+) channel blockers play in the management of seizures?
What role do calcium (Ca+) channel blockers play in the management of seizures?
What is the mechanism of action of ethosuximide in treating seizures?
What is the mechanism of action of ethosuximide in treating seizures?
Flashcards
Action Potential Transmission
Action Potential Transmission
The speed at which electrical signals travel along neurons, impacting seizure activity.
Focal Onset Seizure
Focal Onset Seizure
A seizure that starts in one part of the brain (one hemisphere)
Generalized Onset Seizure
Generalized Onset Seizure
Seizures that start throughout the brain, more widespread than focal.
Absence Seizure
Absence Seizure
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Tonic-Clonic Seizure
Tonic-Clonic Seizure
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Antiepileptic Adverse Effects
Antiepileptic Adverse Effects
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Phenytoin MOA
Phenytoin MOA
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Valproic Acid MOA
Valproic Acid MOA
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Ethosuximide MOA
Ethosuximide MOA
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Benzodiazepines MOA
Benzodiazepines MOA
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What is the effect of slowing down Na+ channels?
What is the effect of slowing down Na+ channels?
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How do Ca+ channel blockers treat absence seizures?
How do Ca+ channel blockers treat absence seizures?
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What is the difference between focal and generalized seizures?
What is the difference between focal and generalized seizures?
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What is the mechanism of Phenytoin?
What is the mechanism of Phenytoin?
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What are the primary effects of Carbamazepine?
What are the primary effects of Carbamazepine?
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What drug is traditionally used for absent seizures?
What drug is traditionally used for absent seizures?
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Why is Valproic Acid considered a 'broad-spectrum' antiepileptic?
Why is Valproic Acid considered a 'broad-spectrum' antiepileptic?
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What are benzodiazepines used for in epilepsy?
What are benzodiazepines used for in epilepsy?
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What are some common adverse effects of antiepileptic medications?
What are some common adverse effects of antiepileptic medications?
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Action Potential and Seizures
Action Potential and Seizures
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Calcium Channels and Absence Seizures
Calcium Channels and Absence Seizures
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Focal vs. Generalized Seizures
Focal vs. Generalized Seizures
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Carbamazepine MOA
Carbamazepine MOA
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Valproic Acid: Broad Spectrum
Valproic Acid: Broad Spectrum
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GABA and Benzodiazepines
GABA and Benzodiazepines
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Common Antiepileptic Adverse Effects
Common Antiepileptic Adverse Effects
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Study Notes
Types of Seizures
- Focal onset seizures: Stay within one hemisphere of the brain. May or may not involve impaired awareness.
- Generalized onset seizures: More problematic, originating in core brain areas (thalamus or brainstem), transmitting signals throughout the brain.
- Absence seizures: Characterized by a brief lapse of awareness (seconds), without loss of posture. Typically childhood onset and resolve in adulthood. Breathing can stop briefly.
- Tonic-clonic seizures: Involve muscle stiffness followed by rhythmic jerking movements.
- Atonic seizures: Sudden, rapid loss of muscle tone.
- Myoclonic seizures: Brief, sudden muscle contractions.
Action Potential and Channel Modulation
- Sodium (Na+) channels are crucial for action potentials. Slowing Na+ channels can slow action potential transmission and suppress seizures.
- Calcium (Ca+) channels are targeted for absence seizure treatment. Blocking Ca+ channels in the hypothalamus can prevent these seizures.
Antiepileptic Drugs (AEDs) and Adverse Effects
- AEDs aim to control seizures, not cure them.
- Common adverse effects: Increased suicidal thoughts, fetal abnormalities, dermatological issues (rashes, Stevens-Johnson syndrome).
Antiepileptic Drug Mechanisms and Uses
- Phenytoin: Inhibits voltage-gated Na+ channels; slows repetitive firing; treats tonic-clonic and focal onset seizures. Adverse effects include gingival hyperplasia and interactions with other drugs.
- Carbamazepine: Inhibits voltage-gated Na+ channels; slows neuron firing; treats focal, focal bilateral and tonic-clonic seizures. Adverse effects: hyponatremia, skin issues, Stevens-Johnson syndrome and drug interactions.
- Oxcarbazepine: Similar to carbamazepine but primarily for focal seizures. Higher risk of hyponatremia, fewer drug interactions, better tolerated.
- Lamotrigine: Inhibits Na+ channels, effective for focal, generalized and tonic-clonic seizures. Adverse effects include suicidal ideation, and Stevens-Johnson syndrome.
- Levetiracetam: Mechanism unknown; treats focal, tonic-clonic, generalized, and myoclonic seizures. Adverse effects include mood and behavior changes.
- Valproic acid: Broad-spectrum AED affecting multiple channels (Na+, Ca+, and influencing GABA); treats generalized, tonic-clonic and myoclonic seizures. Adverse effects: toxicity, liver problems (hepatotoxicity), pancreatitis, pregnancy concerns and metabolic interactions with other medications.
- Ethosuximide: Targets voltage-gated Ca+ channels, first line treatment for absence seizures. Better tolerated.
- Gabapentin: Blocks voltage-gated Ca+ and K+channels; used for focal and tonic seizures, neuropathic pain, and migraine. Well tolerated.
- Pregabalin: Similar mechanism to gabapentin, used for similar applications, but potentially higher risk of adverse effects (weight gain and dry mouth).
- Benzodiazepines: Positive allosteric modulators of GABA receptors. Uses: managing status epilepticus and alcohol withdrawal. Significant adverse effects (sedation, anesthesia, lethargy, behavior problems, GI upset). Sudden withdrawal may increase risk of status epilepticus.
- Drug group ending in "PAM" (e.g. Diazepam) used to manage status epilepticus. Significant adverse effects include respiratory depression.
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