Seizure Types and Classification

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Questions and Answers

What type of seizure is characterized by a brief, shocklike contraction of muscles that may be generalized or restricted to one extremity?

  • Generalized Tonic-Clonic seizure
  • Myoclonic seizure (correct)
  • Focal with Impaired Awareness seizure
  • Absence seizure

What is the main goal of treating seizures with anti-epileptic drugs?

  • To completely eliminate seizures
  • To cure epilepsy
  • To reduce the frequency and severity of seizures (correct)
  • To treat the underlying cause of seizures

What is the typical duration of a Tonic-Clonic seizure?

  • 1-2 minutes (correct)
  • Less than 30 seconds
  • 5-10 minutes
  • More than 30 minutes

What is the term for a seizure that lasts more than 5 minutes or multiple prolonged seizures without full recovery between episodes?

<p>Status Epilepticus (C)</p> Signup and view all the answers

What type of seizure is characterized by a loss of consciousness and a bilaterally synchronous, 3/second spike-and-wave EEG pattern?

<p>Absence seizure (C)</p> Signup and view all the answers

What is the main difference between a Focal seizure and a Generalized seizure?

<p>Location of the seizure (B)</p> Signup and view all the answers

What is the treatment for Status Epilepticus?

<p>All of the above (D)</p> Signup and view all the answers

What is the potential consequence of prolonged seizures?

<p>Permanent neuronal changes and brain damage (B)</p> Signup and view all the answers

What is the primary goal of prophylaxis in epilepsy treatment?

<p>To control seizures in 60-80% of patients (A)</p> Signup and view all the answers

Which ion is involved in enhanced excitatory activity in epilepsy?

<p>Na+ (C)</p> Signup and view all the answers

What is the result of Na+ channel inactivation gate being CLOSED?

<p>Action potential is inhibited (C)</p> Signup and view all the answers

How do anti-epileptic drugs affect GABA transmission?

<p>Inactivate GABAA and decrease GABA reuptake (D)</p> Signup and view all the answers

What is the mechanism of action of anti-epileptic drugs that block Na+ channels?

<p>Promoting the inactive state of Na+ channels (B)</p> Signup and view all the answers

What is the result of the balance between Na+ influx and K+ efflux being disrupted in epilepsy?

<p>Membrane potential increases (C)</p> Signup and view all the answers

Which type of neurotransmitter is involved in reduced inhibitory activity in epilepsy?

<p>GABA (A)</p> Signup and view all the answers

What is the effect of anti-epileptic drugs on Ca2+ channels with a2d subunit?

<p>Inhibition of Ca2+ channels (C)</p> Signup and view all the answers

What is the mechanism of action of phenytoin?

<p>Blockade of Na+ channels (B)</p> Signup and view all the answers

What type of seizures is phenytoin NOT effective against?

<p>Absence seizures (D)</p> Signup and view all the answers

What is a common side effect of carbamazepine?

<p>Dry mouth (D)</p> Signup and view all the answers

What is the mechanism of action of lamotrigine?

<p>Blockade of Na+ channels (A)</p> Signup and view all the answers

What is a potential skin reaction associated with lamotrigine?

<p>Potentially fatal skin reactions (A)</p> Signup and view all the answers

What psychiatric disorder is carbamazepine also used to treat?

<p>Bipolar disorder (C)</p> Signup and view all the answers

What is a common side effect of phenytoin?

<p>All of the above (D)</p> Signup and view all the answers

What is the brand name of carbamazepine?

<p>Tegretol (A)</p> Signup and view all the answers

Which of the following anticonvulsant drugs enhances the length of opening of GABAA receptors?

<p>Phenobarbital (Luminal) (A)</p> Signup and view all the answers

What is the major side effect of Phenobarbital (Luminal)?

<p>Sedation (B)</p> Signup and view all the answers

Which of the following anticonvulsant drugs is used to treat absence and myoclonic seizures?

<p>Clonazepam (Klonopin) (A)</p> Signup and view all the answers

Which of the following anticonvulsant drugs is metabolized to Phenobarbital?

<p>Primidone (Mysoline) (D)</p> Signup and view all the answers

Which of the following anticonvulsant drugs produces physical dependence?

<p>All of the above (D)</p> Signup and view all the answers

Which of the following anticonvulsant drugs has a mechanism of action that is not clear?

<p>Valproic Acid (Valparin) (D)</p> Signup and view all the answers

Which of the following anticonvulsant drugs is used in emergency treatment of Status Epilepticus?

<p>Midazolam (Versed) (B)</p> Signup and view all the answers

Which of the following anticonvulsant drugs is used to treat complex and simple seizures?

<p>Phenobarbital (Luminal) (C)</p> Signup and view all the answers

What is the primary mechanism by which vigabatrin increases GABA concentrations in the brain?

<p>By binding to and inactivating GABA-T (D)</p> Signup and view all the answers

What is the most common side effect of vigabatrin, affecting approximately 30-60% of people?

<p>Permanent vision damage (A)</p> Signup and view all the answers

How does tiagabine increase GABA concentrations in the brain?

<p>By binding to GABA recognition sites on the GAT-1 GABA reuptake transporter (A)</p> Signup and view all the answers

What is the primary mechanism by which vigabatrin and tiagabine increase GABA concentrations in the brain?

<p>Irreversible inhibition of GABA-T and inhibition of GABA reuptake carriers (C)</p> Signup and view all the answers

What is the common side effect of vigabatrin and the anti-epileptic drug mentioned in the text?

<p>Hepatic toxicity and fatal pancreatitis (C)</p> Signup and view all the answers

What is the primary mechanism by which the anti-epileptic drug mentioned in the text increases GABA concentrations?

<p>By enhancing the opening of GABAA receptor Cl- channels (D)</p> Signup and view all the answers

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