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Questions and Answers
Which characteristic differentiates chronic inflammation from acute inflammation?
Which characteristic differentiates chronic inflammation from acute inflammation?
What main type of cell is predominantly involved in chronic inflammation?
What main type of cell is predominantly involved in chronic inflammation?
What is a common outcome of prolonged chronic inflammation regarding tissue appearance?
What is a common outcome of prolonged chronic inflammation regarding tissue appearance?
What is a type of wound characterized by skin being broken and exposing underlying tissues?
What is a type of wound characterized by skin being broken and exposing underlying tissues?
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What happens when the host defense cannot clear the insult in chronic inflammation?
What happens when the host defense cannot clear the insult in chronic inflammation?
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Which of the following factors does NOT influence tissue healing?
Which of the following factors does NOT influence tissue healing?
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Which of these factors contributes to chronic inflammation?
Which of these factors contributes to chronic inflammation?
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During which stage of wound healing does the inflammation response primarily occur?
During which stage of wound healing does the inflammation response primarily occur?
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What is one potential systemic impact of chronic inflammation?
What is one potential systemic impact of chronic inflammation?
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What is the role of angiogenesis in chronic inflammation?
What is the role of angiogenesis in chronic inflammation?
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Which type of wound is classified as unintentional?
Which type of wound is classified as unintentional?
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How does the duration of inflammation influence tissue damage?
How does the duration of inflammation influence tissue damage?
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Which medical therapy is commonly associated with increased risk of wound development?
Which medical therapy is commonly associated with increased risk of wound development?
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Which statement best contrasts acute and chronic inflammation?
Which statement best contrasts acute and chronic inflammation?
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What is NOT a complication associated with wound healing?
What is NOT a complication associated with wound healing?
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What is a possible challenge faced by clinicians treating patients with chronic inflammation?
What is a possible challenge faced by clinicians treating patients with chronic inflammation?
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Which type of wound healing involves the wound edges being brought together?
Which type of wound healing involves the wound edges being brought together?
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What term describes a wound that is clean but may become contaminated?
What term describes a wound that is clean but may become contaminated?
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Which of the following is a risk factor for developing a wound?
Which of the following is a risk factor for developing a wound?
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Which type of wound is characterized by bruising without broken skin?
Which type of wound is characterized by bruising without broken skin?
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What is the first step in the healing process of a wound during primary intention?
What is the first step in the healing process of a wound during primary intention?
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Which phase of wound healing begins when collagen production equals degradation?
Which phase of wound healing begins when collagen production equals degradation?
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During secondary healing, what characterizes the inflammatory phase?
During secondary healing, what characterizes the inflammatory phase?
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What is the role of fibroblasts in the proliferative phase of secondary healing?
What is the role of fibroblasts in the proliferative phase of secondary healing?
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In secondary healing, how is collagen typically laid down?
In secondary healing, how is collagen typically laid down?
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Which of the following is a characteristic of tertiary healing?
Which of the following is a characteristic of tertiary healing?
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What factor does NOT affect wound healing?
What factor does NOT affect wound healing?
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What is the purpose of angiogenesis during the proliferative phase?
What is the purpose of angiogenesis during the proliferative phase?
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Which of the following statements best describes how scar tissue appears after the maturation stage?
Which of the following statements best describes how scar tissue appears after the maturation stage?
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During which phase do increased blood vessels begin to be removed in wound healing?
During which phase do increased blood vessels begin to be removed in wound healing?
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Which of the following is NOT a complication of wound healing?
Which of the following is NOT a complication of wound healing?
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What is the term for a surgical wound that has reopened?
What is the term for a surgical wound that has reopened?
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Which complication of wound healing involves an abnormal tissue growth at the repair site?
Which complication of wound healing involves an abnormal tissue growth at the repair site?
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Which complication is characterized by an abnormal passageway between organs due to wound healing?
Which complication is characterized by an abnormal passageway between organs due to wound healing?
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Which of the following complications could potentially result from poor wound care?
Which of the following complications could potentially result from poor wound care?
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In the context of wound healing, which condition refers to excessive bleeding?
In the context of wound healing, which condition refers to excessive bleeding?
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Which complication of wound healing may require surgical intervention to correct?
Which complication of wound healing may require surgical intervention to correct?
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What can increase the risk of developing a keloid scar following a wound?
What can increase the risk of developing a keloid scar following a wound?
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Which of the following factors is commonly associated with infection in wound healing?
Which of the following factors is commonly associated with infection in wound healing?
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What might be a consequence of excessive dehiscence in a surgical patient?
What might be a consequence of excessive dehiscence in a surgical patient?
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Study Notes
Types of Inflammation
- Inflammation is a natural bodily response to injury or infection.
- Inflammation can be acute or chronic.
- Acute inflammation is a short-term response involving mainly neutrophils as the primary inflammatory cells.
- Chronic inflammation is a long-term response involving mainly lymphocytes as the primary inflammatory cells.
Chronic Inflammation
- It is a delayed response that lasts longer.
- It results in more tissue damage than acute inflammation.
- The body is unable to clear the insult so a granuloma may form as a protective process.
- Granulomas are collections of macrophages that form in response to chronic inflammation.
- Granulomas have their own blood supply allowing them to survive.
Comparison of Acute & Chronic Inflammation
- Acute inflammation is a short-term response, while chronic inflammation lasts longer.
- Neutrophils are the main cells involved in acute inflammation, while lymphocytes are the main cells involved in chronic inflammation.
- Acute inflammation is characterized by redness, heat, swelling, and pain, while chronic inflammation often has less obvious symptoms.
Wound Healing
- Wound healing is a complex process involving different stages and factors.
- There are many causes for wounds, both intentional and unintentional.
- Wounds can be classified into different types based on their characteristics, including open or closed, clean or contaminated.
- Age, gender, nutrition, and systemic diseases can all influence wound healing.
Stages of Wound Healing
- Wound healing can occur by primary, secondary, or tertiary intention.
- Primary intention (first intention) refers to the healing of a clean, closed wound, such as a surgical incision.
- Secondary intention (second intention) refers to the healing of an open wound, such as a deep burn.
- Tertiary intention healing involves intentionally delaying the closure of a wound.
Primary Healing
- Primary intention healing involves three stages: inflammation, proliferation, and maturation.
- The inflammatory stage involves the formation of a blood clot, migration of phagocytes, and fibroblasts.
- The proliferation stage sees epithelial cell proliferation, angiogenesis (formation of new blood vessels), granulation tissue formation, and contraction.
- The maturation stage involves collagen degradation and remodeling, leading to a stronger scar.
Secondary Healing
- The stages of secondary intention healing are similar to those of primary intention, but more intense.
- There is more necrotic tissue present, leading to sloughing.
- Secondary intention healing involves a more abundant blood supply to reduce or prevent infection.
Comparing Primary & Secondary Intention
- Primary intention healing involves the healing of a closed wound, while secondary intention healing involves the healing of an open wound.
- Primary intention healing results in a smaller scar, while secondary intention healing results in a larger scar.
Tertiary Healing
- Tertiary intention healing involves intentional delay of wound closure.
- It is often used for wounds that are contaminated or infected.
- Wound closure is delayed until the infection is controlled.
Factors Affecting Wound Healing
- Wound healing can be affected by both local and systemic factors.
- Local factors include the presence of foreign bodies or infection.
- Systemic factors include age, gender, smoking, nutrition, and diseases.
Complications of Wound Healing
- Complications of wound healing can include hemorrhage, infection, dehiscence (wound opening), fistula (abnormal passage), and keloid scar.
- These complications can be caused by various factors, including inadequate closure, infection, and poor blood supply.
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Description
This quiz covers the essential differences between acute and chronic inflammation, focusing on their characteristics and consequences. You'll explore the role of neutrophils and lymphocytes in these responses, as well as the formation of granulomas. Test your understanding of how inflammation impacts the body.
