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Questions and Answers
What type of passive transfer mechanism is characterized by the movement of drugs along a concentration gradient without the need for a carrier or energy?
What type of passive transfer mechanism is characterized by the movement of drugs along a concentration gradient without the need for a carrier or energy?
- Facilitated diffusion
- Filtration
- Simple diffusion (correct)
- Active transport
Which of the following factors does NOT affect the rate of drug passage across the cell membrane via simple diffusion?
Which of the following factors does NOT affect the rate of drug passage across the cell membrane via simple diffusion?
- Solubility in water
- Presence of a carrier protein (correct)
- Molecular weight and size
- Concentration gradient
What type of passive transport mechanism involves the movement of drugs through water-filled pores in the cell membrane?
What type of passive transport mechanism involves the movement of drugs through water-filled pores in the cell membrane?
- Simple diffusion
- Filtration (correct)
- Facilitated diffusion
- Active transport
Which of the following statements about simple diffusion is NOT correct?
Which of the following statements about simple diffusion is NOT correct?
Which of the following factors can increase the rate of drug passage across the cell membrane via simple diffusion?
Which of the following factors can increase the rate of drug passage across the cell membrane via simple diffusion?
In which medium are basic drugs ionized?
In which medium are basic drugs ionized?
What state are acidic drugs in when present in an acid medium?
What state are acidic drugs in when present in an acid medium?
What happens to basic drugs in an acidic medium?
What happens to basic drugs in an acidic medium?
Which type of drugs are ionized in an acidic medium?
Which type of drugs are ionized in an acidic medium?
What type of medium turns basic drugs into ionized form?
What type of medium turns basic drugs into ionized form?
Which form of weak acid and base drugs is more lipid-soluble and easily absorbed?
Which form of weak acid and base drugs is more lipid-soluble and easily absorbed?
Which of the following factors primarily determines the absorption of weak acid and base drugs?
Which of the following factors primarily determines the absorption of weak acid and base drugs?
For a weak base drug, which form is more likely to be absorbed in the acidic environment of the stomach?
For a weak base drug, which form is more likely to be absorbed in the acidic environment of the stomach?
Which form of a weak acid drug is more likely to undergo renal excretion?
Which form of a weak acid drug is more likely to undergo renal excretion?
Which statement is correct regarding the effect of pH on drug absorption and excretion?
Which statement is correct regarding the effect of pH on drug absorption and excretion?
In which type of media are weak base drugs more unionized?
In which type of media are weak base drugs more unionized?
In which type of media are weak base drugs more ionized?
In which type of media are weak base drugs more ionized?
What happens to the ionization state of weak base drugs in acidic media?
What happens to the ionization state of weak base drugs in acidic media?
What is the predominant form of weak base drugs in alkaline media?
What is the predominant form of weak base drugs in alkaline media?
How does the ionization of weak base drugs change in basic media?
How does the ionization of weak base drugs change in basic media?
What is the significance of the oil/water partition coefficient for a drug?
What is the significance of the oil/water partition coefficient for a drug?
What is the relationship between ionization and lipid solubility of a drug?
What is the relationship between ionization and lipid solubility of a drug?
What is the significance of the pKa value for a drug?
What is the significance of the pKa value for a drug?
Which statement is true regarding the relationship between pH and ionization of a drug?
Which statement is true regarding the relationship between pH and ionization of a drug?
Which factor is NOT directly related to the absorption of a drug?
Which factor is NOT directly related to the absorption of a drug?
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