Types of Drug Passage: Simple Diffusion vs Facilitated Diffusion
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Questions and Answers

What type of passive transfer mechanism is characterized by the movement of drugs along a concentration gradient without the need for a carrier or energy?

  • Facilitated diffusion
  • Filtration
  • Simple diffusion (correct)
  • Active transport

Which of the following factors does NOT affect the rate of drug passage across the cell membrane via simple diffusion?

  • Solubility in water
  • Presence of a carrier protein (correct)
  • Molecular weight and size
  • Concentration gradient

What type of passive transport mechanism involves the movement of drugs through water-filled pores in the cell membrane?

  • Simple diffusion
  • Filtration (correct)
  • Facilitated diffusion
  • Active transport

Which of the following statements about simple diffusion is NOT correct?

<p>It requires a carrier protein (B)</p> Signup and view all the answers

Which of the following factors can increase the rate of drug passage across the cell membrane via simple diffusion?

<p>Increasing the concentration gradient (C)</p> Signup and view all the answers

In which medium are basic drugs ionized?

<p>Alkaline medium (C)</p> Signup and view all the answers

What state are acidic drugs in when present in an acid medium?

<p>Non-ionized (A)</p> Signup and view all the answers

What happens to basic drugs in an acidic medium?

<p>They remain non-ionized (D)</p> Signup and view all the answers

Which type of drugs are ionized in an acidic medium?

<p>Acidic drugs (B)</p> Signup and view all the answers

What type of medium turns basic drugs into ionized form?

<p>Alkaline medium (C)</p> Signup and view all the answers

Which form of weak acid and base drugs is more lipid-soluble and easily absorbed?

<p>The non-ionized (unionized) form (B)</p> Signup and view all the answers

Which of the following factors primarily determines the absorption of weak acid and base drugs?

<p>The pH of the absorption site (D)</p> Signup and view all the answers

For a weak base drug, which form is more likely to be absorbed in the acidic environment of the stomach?

<p>The non-ionized form (D)</p> Signup and view all the answers

Which form of a weak acid drug is more likely to undergo renal excretion?

<p>The ionized form (D)</p> Signup and view all the answers

Which statement is correct regarding the effect of pH on drug absorption and excretion?

<p>Increasing pH favors ionization and excretion of weak acids (D)</p> Signup and view all the answers

In which type of media are weak base drugs more unionized?

<p>Alkaline (D)</p> Signup and view all the answers

In which type of media are weak base drugs more ionized?

<p>Acidic (A)</p> Signup and view all the answers

What happens to the ionization state of weak base drugs in acidic media?

<p>Increase (B)</p> Signup and view all the answers

What is the predominant form of weak base drugs in alkaline media?

<p>Unionized (B)</p> Signup and view all the answers

How does the ionization of weak base drugs change in basic media?

<p>Decreases (A)</p> Signup and view all the answers

What is the significance of the oil/water partition coefficient for a drug?

<p>A higher partition coefficient indicates better lipid solubility and absorption. (D)</p> Signup and view all the answers

What is the relationship between ionization and lipid solubility of a drug?

<p>Decreased ionization leads to higher lipid solubility. (D)</p> Signup and view all the answers

What is the significance of the pKa value for a drug?

<p>It represents the pH at which the drug is 50% ionized and 50% unionized. (B)</p> Signup and view all the answers

Which statement is true regarding the relationship between pH and ionization of a drug?

<p>Drugs are more ionized at pH values below their pKa. (C)</p> Signup and view all the answers

Which factor is NOT directly related to the absorption of a drug?

<p>Molecular weight of the drug (C)</p> Signup and view all the answers

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