8 Questions
What happens when allergens are inhaled for the first time?
IgE antibodies are formed and fixed to mast cells in bronchial mucosa
What happens if these allergens are inhaled again?
They will bind to the fixed antibodies leading to release of mediators from the mast cells
Which type of hypersensitivity reaction is initiated by the process described?
Type I hypersensitivity reaction
Which cells cause inflammation and progression of asthma?
Eosinophils
Which mediators may be responsible for asthma?
Histamines
What is the provocation dose of methacholine necessary to produce a 20% fall in FEV1 known as?
PC20
Which non-antigenic factor is a precipitating factor for asthma?
Exercise
"In extrinsic asthma, the condition is paroxysmal & the patient is free in-between". What characterizes intrinsic asthma?
"The condition is persistent with exacerbations"
Test your knowledge on the pathogenesis of Type I hypersensitivity reaction, which involves the formation of IgE antibodies and the subsequent release of mediators from mast cells upon re-exposure to allergens.
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