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Type I Hypersensitivity Reaction Pathogenesis

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Type I Hypersensitivity Reaction Pathogenesis

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Questions and Answers

What happens when allergens are inhaled for the first time?

IgE antibodies are formed and fixed to mast cells in bronchial mucosa (correct)
IgG antibodies are formed and fixed to mast cells in bronchial mucosa
IgA antibodies are formed and fixed to mast cells in bronchial mucosa
IgM antibodies are formed and fixed to mast cells in bronchial mucosa

What happens if these allergens are inhaled again?

They will be neutralized by the mast cells
They will lead to formation of IgG antibodies
They will not bind to the fixed antibodies
They will bind to the fixed antibodies leading to release of mediators from the mast cells (correct)

Which type of hypersensitivity reaction is initiated by the process described?

Type IV hypersensitivity reaction
Type I hypersensitivity reaction (correct)
Type III hypersensitivity reaction
Type II hypersensitivity reaction

Which cells cause inflammation and progression of asthma?

Eosinophils (A) Signup and view all the answers

Which mediators may be responsible for asthma?

Histamines (D) Signup and view all the answers

What is the provocation dose of methacholine necessary to produce a 20% fall in FEV1 known as?

PC20 (C) Signup and view all the answers

Which non-antigenic factor is a precipitating factor for asthma?

Exercise (C) Signup and view all the answers

"In extrinsic asthma, the condition is paroxysmal & the patient is free in-between". What characterizes intrinsic asthma?

"The condition is persistent with exacerbations" (D) Signup and view all the answers