Podcast
Questions and Answers
Which cells produce allergen specific IgE antibodies?
Which cells produce allergen specific IgE antibodies?
- Basophils
- Mast cells
- B cells (correct)
- T cells
What happens when IgE receptors on mast cells are crosslinked by allergen specific IgE antibodies?
What happens when IgE receptors on mast cells are crosslinked by allergen specific IgE antibodies?
- Mast cells produce IgE antibodies
- Mast cells undergo degranulation (correct)
- Mast cells release their mediators
- Mast cells become sensitized to the allergen
Which of the following symptoms are associated with mast cell mediators?
Which of the following symptoms are associated with mast cell mediators?
- Red, itchy watery eyes
- Sneezing, congestion, runny nose
- Itchy or sore throat, post-nasal drip, cough
- All of the above (correct)
What is the role of allergen-specific IgE antibodies in IgE-mediated allergies?
What is the role of allergen-specific IgE antibodies in IgE-mediated allergies?
What is the typical sequence of events in IgE-mediated allergies?
What is the typical sequence of events in IgE-mediated allergies?
Which of the following is the most appropriate treatment for allergic rhinitis and urticaria?
Which of the following is the most appropriate treatment for allergic rhinitis and urticaria?
Which of the following is NOT a use of H1 antagonists?
Which of the following is NOT a use of H1 antagonists?
What is the main cause of death in anaphylactic shock?
What is the main cause of death in anaphylactic shock?
What is the first step in the treatment of anaphylaxis?
What is the first step in the treatment of anaphylaxis?
Which of the following is the mechanism of action of glucocorticoids in the treatment of anaphylaxis?
Which of the following is the mechanism of action of glucocorticoids in the treatment of anaphylaxis?
Besides treating allergic rhinitis and urticaria, H1 antagonists are also used for which purposes?
Besides treating allergic rhinitis and urticaria, H1 antagonists are also used for which purposes?
What is the mechanism of action of adrenaline in the treatment of anaphylactic shock?
What is the mechanism of action of adrenaline in the treatment of anaphylactic shock?
Which medication is no longer recommended in routine treatment of anaphylaxis?
Which medication is no longer recommended in routine treatment of anaphylaxis?
What is the effect of histamine release on the airways during anaphylactic shock?
What is the effect of histamine release on the airways during anaphylactic shock?
Which complication can arise due to laryngeal edema during anaphylactic shock?
Which complication can arise due to laryngeal edema during anaphylactic shock?
What is the main consequence of the widespread increase in vascular permeability during anaphylactic shock?
What is the main consequence of the widespread increase in vascular permeability during anaphylactic shock?
Which receptor does adrenaline primarily act on to cause vasoconstriction during anaphylaxis?
Which receptor does adrenaline primarily act on to cause vasoconstriction during anaphylaxis?
What happens when adrenaline binds to the β2 adrenergic receptor during anaphylaxis?
What happens when adrenaline binds to the β2 adrenergic receptor during anaphylaxis?
Which receptor is primarily targeted by adrenaline to increase heart rate and contractility during the treatment of anaphylaxis?
Which receptor is primarily targeted by adrenaline to increase heart rate and contractility during the treatment of anaphylaxis?
Which conformational state does the H1 receptor tend towards in the basal state?
Which conformational state does the H1 receptor tend towards in the basal state?
What is the effect of histamine binding to the H1 receptor?
What is the effect of histamine binding to the H1 receptor?
What is the mechanism of action of H1 antagonists?
What is the mechanism of action of H1 antagonists?
What is the main difference between histamine and antihistamine in terms of receptor activation?
What is the main difference between histamine and antihistamine in terms of receptor activation?
What is the primary effect of H1 antagonists on the equilibrium of the H1 receptor?
What is the primary effect of H1 antagonists on the equilibrium of the H1 receptor?
Which generation of H1 antagonists readily crosses the blood-brain barrier to block histaminergic actions in the CNS?
Which generation of H1 antagonists readily crosses the blood-brain barrier to block histaminergic actions in the CNS?
Which generation of H1 antagonists is less selective for the H1 receptor and may bind to cholinergic, alpha-adrenergic, and serotonergic receptors?
Which generation of H1 antagonists is less selective for the H1 receptor and may bind to cholinergic, alpha-adrenergic, and serotonergic receptors?
Which category of H1 antagonists is more selective for the H1 receptor and less likely to bind to other receptors?
Which category of H1 antagonists is more selective for the H1 receptor and less likely to bind to other receptors?
What is a characteristic of topical H1 antagonists in terms of onset of action and administration frequency?
What is a characteristic of topical H1 antagonists in terms of onset of action and administration frequency?
Which generation of H1 antagonists is associated with CNS depression (drowsiness) and dry mouth as adverse effects?
Which generation of H1 antagonists is associated with CNS depression (drowsiness) and dry mouth as adverse effects?
Which second-generation H1 antagonist is ionized at physiological pH and does not cross the BBB?
Which second-generation H1 antagonist is ionized at physiological pH and does not cross the BBB?
How long does it typically take for oral H1 antagonists to reach peak plasma concentrations after administration?
How long does it typically take for oral H1 antagonists to reach peak plasma concentrations after administration?
Where are most H1 antagonists metabolized?
Where are most H1 antagonists metabolized?
What adverse effect is commonly associated with first-generation H1 antagonists?
What adverse effect is commonly associated with first-generation H1 antagonists?
Which adverse effect is NOT commonly associated with antihistamines?
Which adverse effect is NOT commonly associated with antihistamines?
What is the key mediator in atopy and anaphylaxis?
What is the key mediator in atopy and anaphylaxis?
Which receptor antagonist is used to treat dyspepsia?
Which receptor antagonist is used to treat dyspepsia?
