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Type I Hypersensitivity Mediators Quiz

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Questions and Answers

Which pharmacotherapy option inhibits degranulation in mast cells by prolonging or increasing cAMP levels?

Steroids

Antihistamines

Epinephrine (correct)

Non-steroidal anti-inflammatories

In Type II hypersensitivity reactions, what is the mechanism that causes lysis of red blood cells?

Antibody binds to the drug

Antibody binds to RBCs surface and causes lysis (correct)

Drug binds to histamine receptors

Theophylline level increases in mast cells

What is the characteristic of Type III hypersensitivity reactions?

Inhibition of complement activation

Antigen binds directly to mast cells

Antibody mediated cytotoxicity

Immune complex formation of antigens and antibodies (correct)

In Rh factor incompatibility, why does the mother receive antibodies to the Rh antigen after birth?

To avoid hemolytic disease in subsequent pregnancies Signup and view all the answers

How do antihistamines contribute to pharmacotherapy in Type I hypersensitivity reactions?

By blocking histamine receptors Signup and view all the answers

Which type of mediators are pre-formed in granules in Type I Hypersensitivity?

Histamine, Cytokines, Chemoattractants Signup and view all the answers

Which mediators are formed after activation in Type I Hypersensitivity?

Leukotrienes, Prostaglandins, Th2 cytokines Signup and view all the answers

What is the key role of eosinophils in Type I Hypersensitivity?

Production of enzymes and cytokines Signup and view all the answers

What are the effects of systemic anaphylaxis?

Severe bronchiole constriction, edema, and shock Signup and view all the answers

Which cells provide CD40L and IL-4 for B cell activation in Type I Hypersensitivity?

Eosinophils Signup and view all the answers