41 Questions
What is the nature of viruses?
Small intracellular parasites
Which type of viruses first discovered cellular oncogenes in animal retroviruses?
Avian retroviruses
Which of the following is an example of a cellular oncogene first discovered in retroviruses?
Abl1
What type of kinases were first discovered through oncogenic virus research?
Non-Receptor Tyrosine kinases
What is the primary focus of the research on viral oncogenesis mentioned in the text?
Genetic basis of cancer
Approximately what percentage of human cancers are caused by infections according to the text?
18%
Which virus is responsible for the highest percentage of infection-related cancers?
Human papillomaviruses (HPV)
Which virus is associated with Kaposi’s sarcoma and primary effusion lymphoma?
Kaposi’s sarcoma herpesvirus (KSHV)
In which year was the human immunodeficiency virus (HIV) first identified as causing AIDS-associated tumors?
1980
Who discovered a novel type of Papillomavirus DNA (HPV16) detected in HeLa cells and in cervical cancer biopsy samples?
Dürst … zur Hausen
What is the focus of the topic 'Human oncogenic viruses' mentioned in the text?
Biological functions of various viral oncogenic proteins
'Polyomaviruses' are classified under which type of tumour viruses according to the text?
DNA tumour viruses
'Merkel cell carcinoma' is associated with which virus according to the text?
Merkel cell polyomavirus (MCPyV)
When was the discovery of papillomaviruses in skin warts made?
405 BCE
Who developed the cervical smear test known as 'Pap'?
George Papanicolaou
Which virus is responsible for the most cases of infection-related cancers?
Human papillomaviruses (HPV)
What is the primary focus of research on human oncogenic viruses?
The biological functions of various viral oncogenic proteins
Which virus is associated with adult T-cell leukemia?
Human T-lymphotropic virus-1 (HTLV-1)
What is the genomic structure of hepatitis B virus (HBV)?
Double stranded DNA
In which year was the Nobel Prize awarded to Harald zur Hausen for his work related to viruses?
2008
Which virus is responsible for causing posttransplant lymphoma?
Epstein-Barr virus (EBV)
What is the primary cellular target of the HCV core protein?
Mature hepatocytes
Who first proposed Herpes simplex virus type 2 as a cause of cervical cancer?
Fred Rapp
What percentage of human cancers are caused by infections according to the text?
18%
What did Margaret and George Gye develop from a cervical cancer biopsy?
HeLa cell line
Which cellular oncogene was first discovered in retroviruses?
Abl1
What is the primary focus of research on viral oncogenesis mentioned in the text?
Cancer activation pathways
Approximately what diameter are small intracellular parasites, such as viruses, mentioned in the text?
50 nanometers
Which type of kinases were first discovered through oncogenic virus research?
Src
What percentage of human cancers are caused by infections according to the text?
75%
Which virus is associated with Kaposi’s sarcoma and primary effusion lymphoma?
HIV
Who developed the cervical smear test known as 'Pap'?
George Papanicolaou
What is the focus of the topic 'Human oncogenic viruses' mentioned in the text?
Virus-host interactions
Which virus causes malignancies in both immunocompetent and immunosuppressed individuals?
Epstein Barr virus (EBV)
Which virus is responsible for causing Kaposi’s sarcoma and primary effusion lymphoma?
Kaposi’s sarcoma herpesvirus (KSHV/HHV8)
Which virus is associated with nasopharyngeal carcinoma and lymphoma?
Epstein Barr virus (EBV)
Which virus causes adult T-cell leukemia and degenerative neurological disease tropical spastic paraparesis?
Human T-cell leukemia virus type 1 (HTLV-1)
Which virus is responsible for Merkel cell carcinoma, an aggressive rare skin cancer?
Merkel Cell Polyoma virus (MCPyV)
Which virus causes malignancies originating from epithelial cells, lymphocytes, and mesenchymal cells?
Epstein Barr virus (EBV)
Which virus is transmitted via milk and by leukocytes, and can also cause degenerative neurological disease tropical spastic paraparesis?
Human T-cell leukemia virus type 1 (HTLV-1)
'Adult T-cell leukemia' is primarily caused by which virus?
Human T-cell leukemia virus type 1 (HTLV-1)
This quiz covers the learning outcomes for the topic 'Virus-host interactions' in the MSc Cancer 2 Part 1 course at UCL Cancer Institute. It includes understanding the nature of viruses, their interactions with host cells, and the insights they provide about oncogenes, tumour suppressor genes, and the oncogenic process.
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