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Tumor Antigens and Mutated Genes Quiz

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Questions and Answers

What is the concept of immune surveillance proposed by Macfarlane Burnet?

To grow tumors after they are formed

To activate external stimuli to kill tumor cells

To recognize and destroy transformed cells before they grow into tumors (correct)

To stimulate specific, adaptive immune responses

What evidence supports the concept of tumor immunity?

Lymphocyte proliferation in the bloodstream

Cancer risk decreases after immunosuppression

Tumors are always surrounded by red blood cells

Metastases regress after primary tumor removal (correct)

Why is it important to identify tumor antigens in humans?

To prevent immune responses

To cause antibody overproduction

To decrease NK cell presence in tumors

To use as components of tumor vaccines (correct)

Which statement accurately describes tumor-specific antigens?

Expressed on tumor cells but not on normal cells (D) Signup and view all the answers

What is the function of the immune system in relation to tumors?

To recognize and destroy transformed cells before they grow into tumors (C) Signup and view all the answers

What is observed in tumors regarding immune cell infiltrates?

Mononuclear cell infiltrates containing T lymphocytes, NK cells, and macrophages (B) Signup and view all the answers

How do tumors stimulate immune responses?

By stimulating specific, adaptive immune responses (B) Signup and view all the answers

What is the role of tumor antigens in immunotherapy?

Generate effector T cells for immunotherapy (B) Signup and view all the answers

Why do immune responses frequently fail to prevent tumor growth?

Tumors can evade immune detection or suppression by producing inhibitory molecules (C) Signup and view all the answers

What are the implications of recognizing and destroying transformed cells before they grow into tumors?

Preventing the formation of malignant tumors (D) Signup and view all the answers