Tumors of the Skin - Dr. H. Reid

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Questions and Answers

Where do Basal Cell Carcinomas usually occur?

  • Groin area
  • Sun-exposed sites (correct)
  • Palms of the hands
  • Under the feet

What is a common characteristic of actinic keratosis lesions on the lips?

  • Cutaneous horns
  • Rough, sandpaper-like consistency (correct)
  • Yellow coloration
  • Smooth surface

What skin feature is associated with actinic keratosis producing a 'cutaneous horn'?

  • Moist appearance
  • Pigmented appearance
  • Excessive scale formation (correct)
  • Smooth texture

What is a characteristic of the stratum corneum in actinic keratosis?

<p>Thickened with parakeratosis (A)</p> Signup and view all the answers

Who is at high risk of developing Basal Cell Carcinomas?

<p>Middle-aged to older adults (B)</p> Signup and view all the answers

What is the main characteristic of an actinic keratosis lesion?

<p>Rough, sandpaper-like consistency (D)</p> Signup and view all the answers

Which skin tumor type is associated with a 'jigsaw puzzle' pattern of basaloid cells?

<p>Cylindroma (B)</p> Signup and view all the answers

Which of the following skin tumors is associated with a 'frothy or bubbly' cytoplasm due to lipid vesicle content?

<p>Sebaceous adenoma (C)</p> Signup and view all the answers

Which gene mutation is associated with Apocrine carcinoma?

<p>Mutations in CTNNB1 (D)</p> Signup and view all the answers

Which of the following is considered a premalignant skin tumor?

<p>Actinic keratosis (A)</p> Signup and view all the answers

Which of the following is a benign epithelial tumor of the skin?

<p>Seborrheic keratosis (C)</p> Signup and view all the answers

Which skin tumor type shows ductal differentiation and basaloid cell proliferation?

<p>Apocrine carcinoma (D)</p> Signup and view all the answers

Which of the following tumors arise from the apocrine glands?

<p>Cylindroma (B)</p> Signup and view all the answers

Which skin tumor type involves lobular proliferation of sebocytes?

<p>Sebaceous adenoma (A)</p> Signup and view all the answers

Which of the following is a pre-malignant epidermal tumor?

<p>Actinic keratosis (D)</p> Signup and view all the answers

Which of the following tumors arises from the eccrine glands?

<p>Syringoma (C)</p> Signup and view all the answers

Which of the following is a cutaneous manifestation of a tumor of cellular migrants to the skin?

<p>Mycosis fungoides (B)</p> Signup and view all the answers

Which of the following tumors arises from the hair follicles?

<p>Trichoepithelioma (B)</p> Signup and view all the answers

What is the pathogenesis of seborrheic keratosis?

<p>Mutation in FGFR3 (A)</p> Signup and view all the answers

Which of the following is a characteristic feature of seborrheic keratosis?

<p>Uniformly tan to dark brown color (A)</p> Signup and view all the answers

What is the Leser-Trelat sign associated with?

<p>Carcinomas of the gastrointestinal tract (A)</p> Signup and view all the answers

Which of the following is a characteristic appearance of seborrheic keratosis on inspection with a hand lens?

<p>Small, round, pore-like ostia impacted with keratin (C)</p> Signup and view all the answers

Which age group is most commonly affected by seborrheic keratosis?

<p>Middle-aged or older individuals (D)</p> Signup and view all the answers

Which of the following is NOT a common location for seborrheic keratosis lesions?

<p>Palms and soles (D)</p> Signup and view all the answers

What is the term for the redness and swelling that can occur when manipulating a tumor due to the release of mast cell granules?

<p>Darier's sign (B)</p> Signup and view all the answers

Which symptom is associated with a highly malignant tumor in the context of mastocytosis?

<p>Loss of appetite (C)</p> Signup and view all the answers

What gastrointestinal complications may result from the release of a large amount of histamine in mastocytosis?

<p>Ulceration of the stomach and duodenum (A)</p> Signup and view all the answers

In cytology, what staining method reveals purple 'metachromatic' granules within the cytoplasm of mast cells?

<p>Giemsa stain (D)</p> Signup and view all the answers

What term describes the phenomenon where mast cells release histamine, resulting in allergic reactions?

<p>Anaphylaxis (A)</p> Signup and view all the answers

Which condition might occur due to disseminated intravascular coagulation (DIC) in mastocytosis?

<p>Thrombocytopenia (D)</p> Signup and view all the answers

What are the signs associated with a solitary mastocytoma in a 1-year-old child?

<p>&quot;Metachromatic&quot; granules (D)</p> Signup and view all the answers

What might be observed by histology in cases of mastocytosis?

<p>&quot;Oval&quot; cells with centralized nuclei (A)</p> Signup and view all the answers

Which type of cell is responsible for the release of histamine in allergic reactions?

<p>&quot;Mast cells&quot; (B)</p> Signup and view all the answers

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