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Questions and Answers
Tumoral calcinosis is always associated with extreme pain.
Tumoral calcinosis is always associated with extreme pain.
False (B)
A significant proportion of tumoral calcinosis cases are inherited in an autosomal dominant manner.
A significant proportion of tumoral calcinosis cases are inherited in an autosomal dominant manner.
True (A)
The knees are commonly affected by tumoral calcinosis.
The knees are commonly affected by tumoral calcinosis.
False (B)
The skin over the tumoral calcinosis mass can ulcerate and release a milky fluid.
The skin over the tumoral calcinosis mass can ulcerate and release a milky fluid.
In tumoral calcinosis, the underlying bones are typically abnormal.
In tumoral calcinosis, the underlying bones are typically abnormal.
Flashcards
Tumoral Calcinosis
Tumoral Calcinosis
A condition where calcium deposits form around joints, causing painless, calcified soft tissue masses.
Tumoral Calcinosis Location
Tumoral Calcinosis Location
Most commonly affects the hips, shoulders, and elbows, but notably spares the knees.
Tumoral Calcinosis Bone Involvement
Tumoral Calcinosis Bone Involvement
The underlying bone structure remains normal, differentiating it from conditions like gout or pseudogout.
Tumoral Calcinosis Inheritance
Tumoral Calcinosis Inheritance
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Tumoral Calcinosis Cause
Tumoral Calcinosis Cause
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Study Notes
Tumoral Calcinosis
- Presents as painless, calcified soft tissue masses, often around joints.
- Primarily affects Black individuals in their teens and 20s.
- Approximately 33% of cases have an autosomal dominant inheritance pattern.
- Biochemical abnormality in phosphorus metabolism leads to hydroxyapatite deposition.
- This deposition triggers a granulomatous reaction and fibrous capsule formation.
- Imaging shows a progressive, calcified soft tissue mass.
- Skin overlying the mass may ulcerate and secrete a chalky/milky fluid.
- Commonly affects hips, shoulders, and elbows, but typically spares the knees.
- Underlying bone structure remains normal, distinguishing it from conditions like gout and pseudogout.
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