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Tumor Invasion and Spread

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Questions and Answers

What is the characteristic route of metastasis for carcinomas?

Lymphatic spread (correct)

Seeding of body cavities

Direct invasion of adjacent tissues

Hematogenous spread

What is the initial site of spread for lymphatic metastasis?

Bone marrow

Liver

Lungs

Regional draining lymph nodes (correct)

Which molecule downregulation leads to dissociation of attached epithelial tumor cells?

Collagenase

Fibronectin

E-cadherin (correct)

Laminin

What is the characteristic route of metastasis for sarcomas and some carcinomas?

Hematogenous spread Signup and view all the answers

Which type of carcinoma often involves the peritoneum?

Ovarian carcinoma Signup and view all the answers

What is a key characteristic of malignant tumors?

Rapid growth and infiltration Signup and view all the answers

What is a characteristic feature of benign tumors?

Low nuclear to cytoplasmic ratio Signup and view all the answers

What is the hallmark of malignancy?

Metastatic potential Signup and view all the answers

What is the purpose of immunohistochemistry in tumor characterization?

To characterize tumors that are difficult to classify on histology Signup and view all the answers

What is the importance of grading in cancer assessment?

Determining prognosis based on differentiation Signup and view all the answers