Tubulointerstitial Disease: Causes and Pathological Changes

Drug-induced acute interstitial nephritis can be reversed by withdrawing the offending drug.

30% to 40% of affected patients of acute interstitial nephritis have an identified offending drug or mechanism.

NSAIDs can lead to acute tubular injury and acute kidney injury by increasing secretion of prostaglandins.

Acute interstitial nephritis can present with both acute kidney injury and nephrotic syndrome.

Uric acid crystals in tubules can lead to obstruction and acute kidney injury in acute uric acid nephropathy.

Chronic urate nephropathy is caused by acute hyperuricemia in gout.

Nephrocalcinosis is associated with chronic tubulointerstitial disease and renal insufficiency.

CKDu stands for Chronic Kidney Disease of Unique Aetiology.

CKDu is predominantly found in agricultural communities in Sri Lanka and North America.

CKDu primarily affects women between 40-60 years old.