Tuberculosis Throughout History

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Questions and Answers

Which of the following is the top cause of infectious death worldwide, excluding COVID-19?

  • Infectious pulmonary TB
  • Tuberculosis (correct)
  • Bacteria of the Mycobacterium tuberculosis complex
  • Mycobacterial Diseases

What is the curability rate of TB caused by drug-susceptible strains when properly treated?

  • Nearly 100% (correct)
  • Less than 50%
  • Around 30%
  • Over 70%

How is TB most commonly transmitted?

  • Through direct skin-to-skin contact
  • Through sexual contact
  • Through contaminated food
  • Through the airborne spread of droplet nuclei (correct)

What is the genetic variability among M. tuberculosis strains from different parts of the world important for?

<p>Identifying outbreaks (C)</p> Signup and view all the answers

What is the likely age of emergence of M. tuberculosis based on population genomic studies?

<p>70,000 years ago (D)</p> Signup and view all the answers

In how many cases can TB be eventually fatal if left untreated?

<p>Over 70% (C)</p> Signup and view all the answers

Which organs are involved in up to one-third of TB cases?

<p>Other organs besides the lungs (B)</p> Signup and view all the answers

What is the purpose of pharmacological prophylaxis in relation to TB?

<p>Preventing the development of the disease in those who have contracted TB infection (A)</p> Signup and view all the answers

What lifestyle is indicated by the content (65.6%) of M. tuberculosis?

<p>Aerobic (A)</p> Signup and view all the answers

When did M. tuberculosis start to expand globally?

<p>During the Neolithic Age (D)</p> Signup and view all the answers

Which method was initially used for genotyping the bacterium in the 1990s?

<p>IS6110 (C)</p> Signup and view all the answers

In 2019, how many new cases of TB were reported to the World Health Organization (WHO)?

<p>7.1 million (A)</p> Signup and view all the answers

Which countries accounted for two-thirds of all new TB cases in 2019?

<p>India, Indonesia, China, Philippines (D)</p> Signup and view all the answers

What percentage of TB cases occurred in male patients?

<p>57% (C)</p> Signup and view all the answers

Which species of Mycobacteria is the most common and important agent of human disease?

<p>M. tuberculosis (A)</p> Signup and view all the answers

Which organism is characteristically resistant to pyrazinamide and was once transmitted by unpasteurized milk?

<p>M. bovis (A)</p> Signup and view all the answers

What is the size of M. tuberculosis, measured in micrometers?

<p>0.5 μm by 3 μm (B)</p> Signup and view all the answers

What characteristic justifies the classification of mycobacteria as acid-fast bacilli (AFB)?

<p>Their high content of mycolic acids (B)</p> Signup and view all the answers

What is the estimated number of deaths from TB in 2019, including deaths among people with HIV co-infection?

<p>1.4 million (D)</p> Signup and view all the answers

Which of the following organisms is NOT a member of the M. tuberculosis complex?

<p>M. pinnipedii (B)</p> Signup and view all the answers

According to the text, what were some factors that contributed to the increase in reported cases of TB in high-income countries in the late 1980s and early 1990s?

<p>All of the above (D)</p> Signup and view all the answers

According to the text, what was the average decline rate of reported TB cases in the United States between 2007 and 2012?

<p>6.5% (A)</p> Signup and view all the answers

According to the text, what is the annual decline rate of reported TB cases in the United States between 2012 and 2019?

<p>2.1% (B)</p> Signup and view all the answers

According to the text, what were the TB mortality rates in HIV-negative people in 2018?

<p>5-19 per 100,000 population per year (C)</p> Signup and view all the answers

According to the text, what percentage of the MDR-TB cases worldwide may be XDR-TB?

<p>6.2% (A)</p> Signup and view all the answers

According to the text, why do the vast majority of XDR-TB cases remain undiagnosed?

<p>Both A and B (C)</p> Signup and view all the answers

According to the text, what is the most common mode of transmission of M. tuberculosis?

<p>Through airborne droplets (B)</p> Signup and view all the answers

According to the text, what is the legal status of the countries, territories, cities, or areas mentioned in the text?

<p>The text does not provide information about the legal status of these places (A)</p> Signup and view all the answers

According to the text, why must information about cases deemed resistant to all anti-TB drugs be interpreted with caution?

<p>Because susceptibility testing for several second-line drugs is both inaccurate and not reproducible (D)</p> Signup and view all the answers

According to the text, what are the new definitions published by WHO?

<p>Pre-XDR-TB and XDR-TB (C)</p> Signup and view all the answers

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