Trazodone (Desyrel) Flashcards

Study Notes

Trazodone (Desyrel) Overview

Trazodone is categorized as a Serotonin Antagonist Reuptake Inhibitor (SARI).
It falls under Cat C for pregnancy classification and is administered orally (PO).

Indications

Primarily used for major depression and insomnia.
Also indicated for chronic pain, diabetic neuropathy, and anxiety disorders.

Side Effects

Common side effects include drowsiness, confusion, dizziness, and fatigue.
Serious risks: suicidality, hallucinations, arrhythmias, and increased blood pressure (QT interval increase).
Other potential side effects: dry mouth, gastrointestinal disturbances (constipation, diarrhea), sexual dysfunction (erectile dysfunction, priapism), and rashes.

Nursing Responsibilities

Monitor vital signs: blood pressure, pulse, and ECG.
Assess for signs of depression and potential sexual dysfunction.
Conduct CBC and evaluate renal and hepatic function.
Be aware of serotonin syndrome symptoms.

Mechanism of Action

Alters serotonin's effects in the central nervous system (CNS) to achieve therapeutic outcomes.

Contraindications

Contraindicated in individuals with a known allergy, recent myocardial infarction (MI), or those undergoing electroconvulsive therapy.
Use with MAO inhibitors, linezolid, or methylene blue is prohibited due to severe interactions.

Cautions

Use cautiously in patients with cardiovascular disease, a history of suicidality, or renal and hepatic impairments.

Drug Interactions

Combines dangerously with MAOIs, potentially leading to severe reactions.
Concomitant use with linezolid or methylene blue can trigger serotonin syndrome.
Other drug interactions include increased levels of digoxin and phenytoin, CNS depressants leading to enhanced sedation, and nitrates causing lower blood pressure.
Fluoxetine may elevate toxicity levels; ketoconazole and ritonavir also increase levels and toxicity risk.
Carbamazepine can decrease trazodone levels, while NSAIDs and anticoagulants like warfarin increase bleeding risks.
Herbal supplements like kava and St. John’s wort can elevate CNS depression risk and lead to serotonin syndrome.

Description

Test your knowledge on Trazodone, also known as Desyrel, with these flashcards. Covering its classification, indications, and potential side effects, this quiz will help reinforce your understanding of this medication. Perfect for students of pharmacology or anyone interested in medication management.