Questions and Answers
What is the classification of Trazodone (Desyrel)?
Which of the following are indications for Trazodone (Desyrel)?
What are some common side effects of Trazodone (Desyrel)?
What is a nursing responsibility when administering Trazodone (Desyrel)?
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What is the action of Trazodone (Desyrel)?
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Trazodone (Desyrel) is contraindicated in patients with an allergy.
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In which scenarios should caution be used when administering Trazodone (Desyrel)?
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Which of the following could interact with Trazodone (Desyrel)?
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Study Notes
Trazodone (Desyrel) Overview
- Trazodone is categorized as a Serotonin Antagonist Reuptake Inhibitor (SARI).
- It falls under Cat C for pregnancy classification and is administered orally (PO).
Indications
- Primarily used for major depression and insomnia.
- Also indicated for chronic pain, diabetic neuropathy, and anxiety disorders.
Side Effects
- Common side effects include drowsiness, confusion, dizziness, and fatigue.
- Serious risks: suicidality, hallucinations, arrhythmias, and increased blood pressure (QT interval increase).
- Other potential side effects: dry mouth, gastrointestinal disturbances (constipation, diarrhea), sexual dysfunction (erectile dysfunction, priapism), and rashes.
Nursing Responsibilities
- Monitor vital signs: blood pressure, pulse, and ECG.
- Assess for signs of depression and potential sexual dysfunction.
- Conduct CBC and evaluate renal and hepatic function.
- Be aware of serotonin syndrome symptoms.
Mechanism of Action
- Alters serotonin's effects in the central nervous system (CNS) to achieve therapeutic outcomes.
Contraindications
- Contraindicated in individuals with a known allergy, recent myocardial infarction (MI), or those undergoing electroconvulsive therapy.
- Use with MAO inhibitors, linezolid, or methylene blue is prohibited due to severe interactions.
Cautions
- Use cautiously in patients with cardiovascular disease, a history of suicidality, or renal and hepatic impairments.
Drug Interactions
- Combines dangerously with MAOIs, potentially leading to severe reactions.
- Concomitant use with linezolid or methylene blue can trigger serotonin syndrome.
- Other drug interactions include increased levels of digoxin and phenytoin, CNS depressants leading to enhanced sedation, and nitrates causing lower blood pressure.
- Fluoxetine may elevate toxicity levels; ketoconazole and ritonavir also increase levels and toxicity risk.
- Carbamazepine can decrease trazodone levels, while NSAIDs and anticoagulants like warfarin increase bleeding risks.
- Herbal supplements like kava and St. John’s wort can elevate CNS depression risk and lead to serotonin syndrome.
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Description
Test your knowledge on Trazodone, also known as Desyrel, with these flashcards. Covering its classification, indications, and potential side effects, this quiz will help reinforce your understanding of this medication. Perfect for students of pharmacology or anyone interested in medication management.
