Trazodone (Desyrel) Flashcards
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Questions and Answers

What is the classification of Trazodone (Desyrel)?

  • Benzodiazepine
  • Monoamine oxidase inhibitor (MAOI)
  • Selective serotonin reuptake inhibitor (SSRI)
  • Serotonin antagonist reuptake inhibitor (SARI) (correct)
  • Which of the following are indications for Trazodone (Desyrel)?

  • Major depression
  • Insomnia
  • Chronic pain
  • All of the above (correct)
  • What are some common side effects of Trazodone (Desyrel)?

  • Insomnia and confusion
  • Drowsiness and dizziness
  • Nausea and vomiting
  • All of the above (correct)
  • What is a nursing responsibility when administering Trazodone (Desyrel)?

    <p>Monitor blood pressure and pulse.</p> Signup and view all the answers

    What is the action of Trazodone (Desyrel)?

    <p>Alters effects of serotonin in the CNS.</p> Signup and view all the answers

    Trazodone (Desyrel) is contraindicated in patients with an allergy.

    <p>True</p> Signup and view all the answers

    In which scenarios should caution be used when administering Trazodone (Desyrel)?

    <p>All of the above</p> Signup and view all the answers

    Which of the following could interact with Trazodone (Desyrel)?

    <p>All of the above</p> Signup and view all the answers

    Study Notes

    Trazodone (Desyrel) Overview

    • Trazodone is categorized as a Serotonin Antagonist Reuptake Inhibitor (SARI).
    • It falls under Cat C for pregnancy classification and is administered orally (PO).

    Indications

    • Primarily used for major depression and insomnia.
    • Also indicated for chronic pain, diabetic neuropathy, and anxiety disorders.

    Side Effects

    • Common side effects include drowsiness, confusion, dizziness, and fatigue.
    • Serious risks: suicidality, hallucinations, arrhythmias, and increased blood pressure (QT interval increase).
    • Other potential side effects: dry mouth, gastrointestinal disturbances (constipation, diarrhea), sexual dysfunction (erectile dysfunction, priapism), and rashes.

    Nursing Responsibilities

    • Monitor vital signs: blood pressure, pulse, and ECG.
    • Assess for signs of depression and potential sexual dysfunction.
    • Conduct CBC and evaluate renal and hepatic function.
    • Be aware of serotonin syndrome symptoms.

    Mechanism of Action

    • Alters serotonin's effects in the central nervous system (CNS) to achieve therapeutic outcomes.

    Contraindications

    • Contraindicated in individuals with a known allergy, recent myocardial infarction (MI), or those undergoing electroconvulsive therapy.
    • Use with MAO inhibitors, linezolid, or methylene blue is prohibited due to severe interactions.

    Cautions

    • Use cautiously in patients with cardiovascular disease, a history of suicidality, or renal and hepatic impairments.

    Drug Interactions

    • Combines dangerously with MAOIs, potentially leading to severe reactions.
    • Concomitant use with linezolid or methylene blue can trigger serotonin syndrome.
    • Other drug interactions include increased levels of digoxin and phenytoin, CNS depressants leading to enhanced sedation, and nitrates causing lower blood pressure.
    • Fluoxetine may elevate toxicity levels; ketoconazole and ritonavir also increase levels and toxicity risk.
    • Carbamazepine can decrease trazodone levels, while NSAIDs and anticoagulants like warfarin increase bleeding risks.
    • Herbal supplements like kava and St. John’s wort can elevate CNS depression risk and lead to serotonin syndrome.

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    Description

    Test your knowledge on Trazodone, also known as Desyrel, with these flashcards. Covering its classification, indications, and potential side effects, this quiz will help reinforce your understanding of this medication. Perfect for students of pharmacology or anyone interested in medication management.

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