Travel and Bloody Diarrhea Quiz
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Questions and Answers

What is the primary acid-base disturbance observed during the first 20 minutes of aspirin toxicity?

  • Mixed metabolic acidosis-respiratory alkalosis
  • Respiratory alkalosis (correct)
  • Metabolic alkalosis
  • Respiratory acidosis
  • What is the treatment for hypercalcemia when the calcium level is between 10.2 to 12 mEq/L?

  • Normal saline (0.9% NaCl) regardless of symptoms (correct)
  • Normal saline (0.9% NaCl) only if symptomatic
  • Calcium supplementation
  • Bisphosphonate immediately
  • What type of incontinence is characterized by a need to rush to the bathroom triggered by the sound of a key in a door?

  • Functional incontinence
  • Stress incontinence
  • Urge incontinence (correct)
  • Overflow incontinence
  • Which of the following symptoms is indicative of Wernicke encephalopathy?

    <p>Ataxia and confusion</p> Signup and view all the answers

    What is the expected calcium and PTH status in a patient with hypercalcemia due to sarcoidosis?

    <p>High calcium and low PTH</p> Signup and view all the answers

    What is the pharmacological treatment for urge incontinence?

    <p>Oxybutynin</p> Signup and view all the answers

    In cases of chronic respiratory acidosis accompanied by confusion, which electrolyte disturbance may be suspected?

    <p>Hypercalcemia</p> Signup and view all the answers

    What is the treatment approach for TCA toxicity?

    <p>Sodium bicarbonate</p> Signup and view all the answers

    What is the most common cause of otitis media?

    <p>Streptococcus pneumoniae</p> Signup and view all the answers

    What is the appropriate treatment for recurrent otitis media?

    <p>Amoxicillin/clavulanate</p> Signup and view all the answers

    In which situation should tympanostomy tubes be considered?

    <p>Three or more episodes of otitis media in 6 months</p> Signup and view all the answers

    What indicates iron deficiency anemia based on hematocrit and serum markers?

    <p>Low hematocrit + low MCV + high transferrin</p> Signup and view all the answers

    Which condition is characterized by microcytic anemia that does not improve with iron supplementation?

    <p>Thalassemia</p> Signup and view all the answers

    What is the recommended treatment for anemia of chronic disease if renal failure is the cause?

    <p>Erythropoietin (EPO)</p> Signup and view all the answers

    In a patient with normotensive stroke, what diagnostic test should be performed first?

    <p>Electrocardiogram (ECG)</p> Signup and view all the answers

    What is a common cause of anovulation accompanied by hirsutism in females?

    <p>Polycystic ovary syndrome (PCOS)</p> Signup and view all the answers

    What is the effect of abnormal GnRH pulsation in terms of LH/FSH ratio in anovulation?

    <p>It leads to a high LH/FSH ratio.</p> Signup and view all the answers

    What primary role does FSH play in the female reproductive system?

    <p>Stimulates granulosa cells to produce aromatase.</p> Signup and view all the answers

    Which treatment approach is recommended first for a patient with PCOS and a high BMI?

    <p>Weight loss.</p> Signup and view all the answers

    How does PCOS increase the risk of endometrial cancer?

    <p>Due to high levels of unopposed estrogen.</p> Signup and view all the answers

    Which treatment is appropriate for acute gout if indomethacin is not effective?

    <p>Colchicine.</p> Signup and view all the answers

    What type of crystals is diagnosed in pseudogout?

    <p>Calcium pyrophosphate crystals.</p> Signup and view all the answers

    What is the genetic basis of Lesch-Nyhan syndrome?

    <p>X-linked HGPRT deficiency.</p> Signup and view all the answers

    What is the primary role of leuprolide in the treatment of prostate cancer?

    <p>Inhibits testosterone production.</p> Signup and view all the answers

    What is the most specific antibody for systemic lupus erythematosus (SLE)?

    <p>Anti-Sm (anti-Smith)</p> Signup and view all the answers

    Which is the next best step in diagnosing viral-induced aplastic anemia?

    <p>Bone marrow aspiration</p> Signup and view all the answers

    What is the mechanism behind immune thrombocytopenic purpura (ITP)?

    <p>Antibodies against GpIIb/IIIa on platelets</p> Signup and view all the answers

    What treatment is considered the most effective way to decrease recurrence of ITP episodes?

    <p>Splenectomy</p> Signup and view all the answers

    Which laboratory finding is characteristic of hemophilia?

    <p>Normal PT and increased aPTT</p> Signup and view all the answers

    What is the main role of von Willebrand Factor (vWF)?

    <p>Promoting platelet adhesion</p> Signup and view all the answers

    Which of these statements about the heme findings in immune thrombocytopenic purpura (ITP) is accurate?

    <p>Increased bleeding time, normal PT, normal aPTT</p> Signup and view all the answers

    Which of the following drugs is associated with drug-induced lupus?

    <p>Penicillamine</p> Signup and view all the answers

    Which treatment is considered a last resort for asthma management?

    <p>Oral steroids</p> Signup and view all the answers

    What is the confirmatory diagnostic method for Goodpasture syndrome?

    <p>Renal biopsy showing linear immunofluorescence</p> Signup and view all the answers

    Which condition is indicated by hematuria combined with eosinophilia?

    <p>Churg-Strauss syndrome</p> Signup and view all the answers

    A patient with chronic mucocutaneous candidiasis has impaired cell-mediated immunity due to which dysfunction?

    <p>T cell dysfunction</p> Signup and view all the answers

    In the case of acute pancreatitis, which diagnostic marker is most indicative of choledocholithiasis?

    <p>High ALP with high direct bilirubin and normal amylase</p> Signup and view all the answers

    Which imaging technique is best suited for viewing gallbladder disease?

    <p>Ultrasound</p> Signup and view all the answers

    What is the most effective way to decrease the recurrence of asthma symptoms in a pediatric patient already using a SABA?

    <p>Initiating ICS therapy</p> Signup and view all the answers

    What is the typical test to diagnose primary biliary cirrhosis (PBC)?

    <p>Anti-mitochondrial antibodies test</p> Signup and view all the answers

    Which fungal infection is characterized by a history of a rose thorn injury?

    <p>Sporotrichosis</p> Signup and view all the answers

    In a patient presenting with fever and abdominal pain post-cholecystectomy, which condition should be suspected?

    <p>Post-operative bile leak</p> Signup and view all the answers

    In patients with SCID, what is the most common infectious presentation?

    <p>Bacterial, fungal, protozoal, and viral infections</p> Signup and view all the answers

    Which test is next best after identifying antibodies in Goodpasture syndrome?

    <p>Renal biopsy</p> Signup and view all the answers

    What is the hallmark histological feature of Wegener's granulomatosis?

    <p>C-ANCA positivity</p> Signup and view all the answers

    With high ALP, high direct bilirubin, and normal amylase or lipase after a remote cholecystectomy, what is the likely diagnosis?

    <p>Pancreatic cancer</p> Signup and view all the answers

    What is the primary role of von Willebrand factor (vWF) in platelet function?

    <p>To bridge platelet GpIb to collagen</p> Signup and view all the answers

    Which of the following is an expected clinical manifestation of von Willebrand disease (vWD)?

    <p>Menorrhagia</p> Signup and view all the answers

    What underlying condition often causes vitamin K deficiency in adults?

    <p>Chronic antibiotic use</p> Signup and view all the answers

    What mutation is responsible for sickle cell disease?

    <p>Glutamic acid to valine</p> Signup and view all the answers

    Which drug is commonly used to increase the release of von Willebrand factor?

    <p>Desmopressin</p> Signup and view all the answers

    What is the strongest indication for anticoagulation therapy?

    <p>Prosthetic valve in the heart</p> Signup and view all the answers

    Which class of antibiotics is often used for the treatment of febrile neutropenia?

    <p>Broad-spectrum IV antibiotics</p> Signup and view all the answers

    How is ganciclovir primarily used in medical treatment?

    <p>Treatment of cytomegalovirus infections</p> Signup and view all the answers

    At what age should the first dose of the MMR vaccine be administered?

    <p>12-15 months</p> Signup and view all the answers

    What is the correct follow-up vaccine for individuals aged 65 or older who received the Pneumo PCV13?

    <p>PPSV23</p> Signup and view all the answers

    In individuals with centri-acinar emphysema, what is the most likely contributing factor?

    <p>Cigarette smoking</p> Signup and view all the answers

    What characteristic of emphysema is typically observed in a young adult non-smoker with a family history of hepatic cirrhosis?

    <p>Pan-acinar emphysema</p> Signup and view all the answers

    In cases of restrictive lung disease, how is the FEV1/FVC ratio typically affected?

    <p>Normal or increased</p> Signup and view all the answers

    What is the primary result of the acid-base disturbance in aspirin toxicity after the first 20 minutes?

    <p>Mixed metabolic acidosis-respiratory alkalosis</p> Signup and view all the answers

    Which treatment is recommended for symptomatic hypercalcemia with levels above 14 mEq/L?

    <p>Normal saline with additional therapies</p> Signup and view all the answers

    What is the underlying cause of low calcium or potassium levels that do not respond to supplementation?

    <p>Hypomagnesemia</p> Signup and view all the answers

    Which condition is primarily indicated by ataxia, confusion, and ophthalmoplegia?

    <p>Wernicke encephalopathy</p> Signup and view all the answers

    What is the main characteristic symptoms of urge incontinence in a patient with multiple sclerosis?

    <p>Sudden urge to urinate</p> Signup and view all the answers

    In a young African American woman presenting with a dry cough and normal chest X-ray findings, what is the most likely diagnosis?

    <p>Asthma</p> Signup and view all the answers

    Which treatment is commonly used for urge incontinence if pelvic floor exercises are insufficient?

    <p>Oxybutynin</p> Signup and view all the answers

    What is the reasoning behind hypercalcemia seen in sarcoidosis with low PTH levels?

    <p>Vitamin D related hypercalcemia</p> Signup and view all the answers

    What is the most common cause of otitis externa?

    <p>Pseudomonas aeruginosa</p> Signup and view all the answers

    What is the typical treatment for earwax buildup?

    <p>Carbamide peroxide drops</p> Signup and view all the answers

    Which laboratory findings are indicative of iron deficiency anemia?

    <p>Low hematocrit, low MCV, low ferritin</p> Signup and view all the answers

    In a patient presenting with anemia and low hematocrit, what abnormality is expected in thalassemia?

    <p>Normal iron and normal ferritin</p> Signup and view all the answers

    Which treatment is appropriate for patients with anemia of chronic disease when renal failure is not the cause?

    <p>Treating the underlying condition</p> Signup and view all the answers

    What characterizes the hematological profile in iron deficiency anemia compared to thalassemia?

    <p>Increased RDW</p> Signup and view all the answers

    In patients with recurrent otitis media, when is a tympanostomy tube indicated?

    <p>Four or more episodes in a year</p> Signup and view all the answers

    What is the treatment for otitis media caused by Streptococcus pneumoniae?

    <p>Oral amoxicillin</p> Signup and view all the answers

    What causes hirsutism in women experiencing anovulation?

    <p>High LH/FSH ratio due to abnormal GnRH pulsation</p> Signup and view all the answers

    Why does a high LH/FSH ratio contribute to anovulation and PCOS?

    <p>It causes follicular maturation without ovulation</p> Signup and view all the answers

    What is the role of FSH in the female reproductive system?

    <p>Promotes the production of aromatase in granulosa cells</p> Signup and view all the answers

    What is the first-line treatment for a patient with PCOS and a high BMI?

    <p>Weight loss</p> Signup and view all the answers

    Which treatment should be avoided in patients with a history of uric acid stones?

    <p>Probenecid</p> Signup and view all the answers

    In patients with pseudogout, what is the main crystal type found?

    <p>Calcium pyrophosphate crystals</p> Signup and view all the answers

    What is the most effective drug for acute gout treatment in patients with renal insufficiency?

    <p>Steroids</p> Signup and view all the answers

    What is the genetic cause of Lesch-Nyhan syndrome?

    <p>HGPRT deficiency</p> Signup and view all the answers

    What symptom is typically associated with a platelet problem in von Willebrand disease (vWD)?

    <p>Petechiae</p> Signup and view all the answers

    What is the secondary function of von Willebrand factor (vWF) in the blood?

    <p>Stabilizes factor VIII in plasma</p> Signup and view all the answers

    Which of the following drugs is associated with causing agranulocytosis?

    <p>Clozapine</p> Signup and view all the answers

    What is a common clinical presentation of sickle cell disease related to the kidneys?

    <p>Renal papillary necrosis</p> Signup and view all the answers

    What is the recommended treatment for febrile neutropenia?

    <p>Immediate broad-spectrum IV antibiotics</p> Signup and view all the answers

    Which condition is indicated by a deficiency of vitamin K?

    <p>Increased PT and aPTT with normal bleeding time</p> Signup and view all the answers

    What inherent genetic inheritance pattern does sickle cell disease possess?

    <p>Autosomal recessive</p> Signup and view all the answers

    Which of the following best describes the role of desmopressin in the treatment of von Willebrand disease?

    <p>Increases release of von Willebrand factor</p> Signup and view all the answers

    What is the primary treatment for sarcoidosis?

    <p>Steroids</p> Signup and view all the answers

    Which of the following conditions is characterized by hematuria and hemoptysis?

    <p>Goodpasture syndrome</p> Signup and view all the answers

    In the diagnosis of primary biliary cirrhosis (PBC), which antibody is most indicative?

    <p>Anti-mitochondrial antibodies</p> Signup and view all the answers

    Which treatment is recommended as a last resort for managing asthma symptoms?

    <p>Oral steroids</p> Signup and view all the answers

    What is the most effective way to decrease the recurrence of asthma in a child already using a SABA?

    <p>Inhaled corticosteroids</p> Signup and view all the answers

    What type of imaging is preferred for viewing gallbladder in suspected cholecystitis?

    <p>Ultrasound</p> Signup and view all the answers

    Which finding is typical in a patient with chronic mucocutaneous candidiasis?

    <p>T cell dysfunction</p> Signup and view all the answers

    What is the mechanism of action for Bruton’s agammaglobulinemia?

    <p>Tyrosine kinase mutation</p> Signup and view all the answers

    Which condition is associated with eosinophilia in an asthma patient?

    <p>Churg-Strauss syndrome</p> Signup and view all the answers

    In a patient who had a recent cholecystectomy with fever and abdominal pain, what condition should be suspected?

    <p>Post-op bile leak</p> Signup and view all the answers

    What is the confirmatory test for Goodpasture syndrome?

    <p>Renal biopsy</p> Signup and view all the answers

    What is the next best step for a patient diagnosed with choledocholithiasis?

    <p>ERCP</p> Signup and view all the answers

    In Churg-Strauss syndrome, which laboratory marker is typically observed?

    <p>p-ANCA</p> Signup and view all the answers

    Which condition is typically characterized by greasy, scaly scalp with itchy papules in adults?

    <p>Seborrheic dermatitis</p> Signup and view all the answers

    Study Notes

    Travel Diarrhea

    • Traveler diarrhea is often caused by ETEC, HL or HS toxins. Bloody diarrhea after poultry consumption is often Campylobacter jejuni or Salmonella.
    • Antibiotic use associated with diarrhea can cause C. difficile.
    • Fever of 104°F + abdominal distension with C.diff suggests toxic megacolon and warrants a laparotomy.
    • Treatment for C.diff is vancomycin, not metronidazole.
    • Bloody diarrhea and travel history could be Entamoeba histolytica.
    • Treatment is metronidazole + iodoquinol or paromomycin.
    • Close quarters, military, cruise ship or other similar environments + watery diarrhea could be Norwalk virus.
    • Children <5 years with watery diarrhea, Rotavirus is likely.

    Bloody Diarrhea

    • Few organisms causing bloody diarrhea are Shigella.
    • Bloody diarrhea +appendicitis-like pain in a child might be Yersinia enterocolitica.
    • Bloody diarrhea + reactive arthritis in a adult could be related to Y. enterocolitica, Campylobacter, Shigella or Salmonella.
    • Diarrhea and Guillain-Barré syndrome might indicate Campylobacter infection.

    Cardiac Ischemia

    • ECG stress test is first-line for evaluating suspected cardiac ischemia.
    • If baseline ECG shows abnormalities (e.g., BBB), an echo stress test may be necessary.
    • A dobutamine stress echo is indicated for those unable to exercise on an ECG stress test.

    Pericarditis

    • Diffuse ST-segment elevations on ECG suggest pericarditis.
    • Pericarditis is often associated with central chest pain that is worsened when lying supine and improved when leaning forward.
    • Pericarditis following viral infection can lead to increased creatine kinase.
    • Posterior MI is suggested by ST-segment depressions in anterior ECG leads.
    • Pericardial effusion or tamponade presents with pulsus paradoxus (systolic blood pressure drop >10 mmHg with inspiration).
    • Beck's triad (hypotension; muffled heart sounds; jugular venous distension) strongly suggests pericardial tamponade.

    Pneumonia

    • Pneumonia in CF patients <10 years is most commonly caused by S. aureus and >10yrs by Pseudomonas.
    • Pneumonia following influenza infection is commonly caused by S. aureus.
    • Pneumonia associated with rabbits is F. tularensis
    • Pneumonia associated with cattle is Coxiella (Q fever)
    • Pneumonia associated with birds is Chlamydia psittaci

    Pulmonary Embolism

    • Leg swelling, pain, shortness of breath signifies pulmonary embolism potentially caused by deep vein thrombosis.
    • In pregnant women, V/Q scan instead of CT is required for PE diagnosis and management.
    • Someone already on warfarin (blood thinner) needs a spiral CT to confirm and an IVC filter for treatment.

    Acid-base disturbances

    • Respiratory alkalosis (low CO2, high pH) is common in PE and asthma.
    • Aspirin toxicity also causes respiratory alkalosis during the initial 20 minutes.

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