30 Questions
What is the volume of oxygen in ml present in chemical combination with Hb in 100ml blood when fully saturated?
25 ml
Which factor determines the rate and direction of oxygen diffusion in the blood?
Oxygen tension
What is the nature of oxygen when it combines with iron (Fe+2) of hemoglobin?
HbO2
Which form of oxygen constitutes about 2% in blood?
O2 in physical solution
What determines the percentage of hemoglobin saturation?
Oxygen tension
What is the volume of oxygen in ml present in 100ml arterial blood with a PO2 of 100mmHg?
0.3 ml
Which compound determines the O2 capacity and O2 content present in blood?
Hemoglobin
What is the shape of the myoglobin dissociation curve?
Rectangular hyperbola
At what pO2 level is myoglobin fully saturated with oxygen during rest?
40 mmHg
What is the role of myoglobin in skeletal muscle?
It acts as an oxygen store
What happens to myoglobin's oxygen during muscle exercise?
It decreases
In which form does myoglobin combine with oxygen?
Cubic
What happens to the p50 value in a left shift of the oxygen dissociation curve?
It decreases
What tests should be ordered to calculate a patient's blood oxygen concentration?
Blood draw, arterial blood gas, pulse oximetry, hemoglobin level
What kind of pigment is myoglobin?
Iron-containing pigment
At what tissue level does myoglobin give its oxygen to the muscles?
pO2 below 40 mmHg
At which partial pressure of oxygen (PO2) does hemoglobin (Hb) become 90% saturated with oxygen?
$PO_2 = 60$ mmHg
What is the oxygen content of arterial blood at a $PO_2$ of 100 mmHg?
19 ml/100 ml blood
What is the percentage of hemoglobin saturation with oxygen in venous blood at a $PO_2$ of 40 mmHg?
70%
Which part of the oxygen-hemoglobin dissociation curve represents the release of oxygen to tissues?
The steep portion
What is the significance of the sigmoid shape of the oxygen-hemoglobin dissociation curve?
It allows easy and almost complete saturation of hemoglobin at the lungs, even when oxygen tension is low.
At high altitudes, what is the approximate partial pressure of oxygen (PO2) in the lungs?
$PO_2 = 60$ mmHg
What is the oxygen capacity of hemoglobin?
20 ml/100 ml blood
What is the primary function of the steep portion of the oxygen-hemoglobin dissociation curve?
To allow easy and rapid release of oxygen from hemoglobin to the tissues at low partial pressures of oxygen
What is the significance of the p50 value in the oxygen-hemoglobin dissociation curve?
It represents the partial pressure of oxygen at which hemoglobin is 50% saturated with oxygen
Which of the following factors causes a right shift in the oxygen-hemoglobin dissociation curve, decreasing the affinity of hemoglobin for oxygen?
All of the above
What is the effect of a left shift in the oxygen-hemoglobin dissociation curve?
Increased affinity of hemoglobin for oxygen, leading to decreased oxygen release to tissues
Which form of hemoglobin has a higher affinity for oxygen?
Relaxed form
What is the effect of carbon monoxide poisoning on the oxygen-hemoglobin dissociation curve?
It causes a left shift in the curve
Which of the following statements is true about the shape of the oxygen-hemoglobin dissociation curve?
The S-shape is due to the presence of four heme groups in hemoglobin, each with different affinities for oxygen
Prepare for Dr. Ghada Elgarawany's lecture on the transport of oxygen in the human body. Test your knowledge on diffusion of respiratory gases, mechanisms of oxygen transport, the oxygen-hemoglobin dissociation curve, and its significance.
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