Podcast
Questions and Answers
What is the main characteristic of graft rejection?
What is the main characteristic of graft rejection?
- It involves the acceptance of transplanted tissue by the immune system
- It leads to the destruction of the transplanted tissue (correct)
- It is irreversible
- It can recur even after successful transplant
Which type of mice exhibit no functional, mature T-cells due to a lack of thymus?
Which type of mice exhibit no functional, mature T-cells due to a lack of thymus?
- Inbred mouse Strain A
- Nude mice (correct)
- Mice with homozygous gene loci
- Strain B mouse
What is the role of CD4+ and CD8+ cells in graft rejection?
What is the role of CD4+ and CD8+ cells in graft rejection?
- CD4+ cells lead to rejection while CD8+ cells prevent rejection
- CD8+ cells lead to rejection while CD4+ cells prevent rejection
- Both CD4+ and CD8+ cells have no role in graft rejection
- Both CD4+ and CD8+ cells have a role in graft rejection (correct)
Which pathway involves T cell recognition of intact alloantigen on host dendritic cells?
Which pathway involves T cell recognition of intact alloantigen on host dendritic cells?
What must be minimized to reduce the chances of rejection in transplantation?
What must be minimized to reduce the chances of rejection in transplantation?
What does graft rejection display in terms of specificity and memory?
What does graft rejection display in terms of specificity and memory?
What is the key characteristic of graft rejection?
What is the key characteristic of graft rejection?
In graft rejection, which pathway involves recipient T cells recognizing allogeneic MHC plus associated peptides directly?
In graft rejection, which pathway involves recipient T cells recognizing allogeneic MHC plus associated peptides directly?
What is the role of dendritic cells in graft rejection?
What is the role of dendritic cells in graft rejection?
What is the consequence of removing both CD4+ and CD8+ cells in graft rejection?
What is the consequence of removing both CD4+ and CD8+ cells in graft rejection?
Why is it important for the donor to be as close as possible in HLA match to the recipient in transplantation?
Why is it important for the donor to be as close as possible in HLA match to the recipient in transplantation?
What is the main characteristic of Nude mice regarding graft rejection?
What is the main characteristic of Nude mice regarding graft rejection?
What type of mice exhibit no functional, mature T-cells due to a lack of thymus?
What type of mice exhibit no functional, mature T-cells due to a lack of thymus?
Why must a patient take immunosuppressive treatment post-transplantation?
Why must a patient take immunosuppressive treatment post-transplantation?
