Transplantation Immunology Quiz

Determinants of Immune Response in Transplantation

• The type and severity of the immune response in transplantation are determined by the degree of HLA mismatch between the donor and recipient

Role of HLA Proteins in Transplantation

• The major histocompatibility complex (MHC) system encodes for HLA proteins, which are recognized as foreign by the recipient immune system

Types of Grafts

• Autograft: involves grafting from one area to another in the same individual
• Other types of grafts: allograft, xenograft, and isograft

Immune Privileged Sites

• Transplanted organs at immune privileged sites (e.g. the eye, brain, and pregnant uterus) are generally accepted without significant immune reaction due to the local immune suppression mechanisms

Tissue Compatibility in Transplantation

• The compatibility (or incompatibility) of transplanted tissue is determined by the degree of HLA matching between the donor and recipient
• HLA matching is critical for successful transplantation, as it affects the risk of graft rejection and immunological complications