Guyton 36 book. Transfusion Reactions and Blood Types Quiz
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Questions and Answers

Which blood type contains both A and B agglutinogens but lacks agglutinins?

  • Type AB (correct)
  • Type O
  • Type B
  • Type A
  • What is the primary cause of agglutination in a transfusion reaction?

  • The presence of agglutinogens in the recipient's plasma.
  • The destruction of RBC membranes by phagocytes.
  • The presence of agglutinins in the donor's RBCs.
  • The interaction of agglutinins in the plasma with corresponding agglutinogens on RBCs. (correct)
  • What is the significance of agglutinins having multiple binding sites?

  • It ensures that only specific agglutinins bind to their corresponding agglutinogens.
  • It allows for faster destruction of agglutinated RBCs.
  • It enables a single agglutinin to bind to multiple RBCs, enhancing agglutination. (correct)
  • It increases the likelihood of a transfusion reaction.
  • Immediately after birth, what is the typical quantity of agglutinins present in an infant's plasma?

    <p>Low, with almost zero agglutinins present. (C)</p> Signup and view all the answers

    What is the primary mechanism behind hemolysis in a transfusion reaction?

    <p>All of the above. (D)</p> Signup and view all the answers

    How does agglutination lead to the plugging of small blood vessels?

    <p>The presence of agglutinins in the plasma triggers vasoconstriction, narrowing the blood vessels. (B)</p> Signup and view all the answers

    In a transfusion reaction, what happens to the agglutinated RBCs?

    <p>They are transported to the spleen for destruction. (D)</p> Signup and view all the answers

    What is the primary cause of death in infants with erythroblastosis fetalis?

    <p>Severe anemia (B)</p> Signup and view all the answers

    What is the mechanism by which bilirubin causes damage to the brain in infants with erythroblastosis fetalis?

    <p>Bilirubin precipitates in neuronal cells, causing cell death (D)</p> Signup and view all the answers

    What is the primary goal of blood transfusions in treating erythroblastosis fetalis?

    <p>To prevent the buildup of bilirubin in the infant's blood (B), To increase the infant's red blood cell count (C)</p> Signup and view all the answers

    What is the rationale for using Rh-negative blood for transfusions in infants with erythroblastosis fetalis?

    <p>Rh-negative blood does not contain the Rh factor that the mother's antibodies target (C)</p> Signup and view all the answers

    How does the body typically eliminate bilirubin?

    <p>Through the liver and bile (B)</p> Signup and view all the answers

    What is the main reason why jaundice is less common in adults compared to infants?

    <p>Adults have more efficient liver function (C)</p> Signup and view all the answers

    Why is kidney failure a potentially lethal consequence of transfusion reactions?

    <p>Kidney failure can lead to a buildup of toxins in the blood (B)</p> Signup and view all the answers

    What is the primary mechanism by which transfusion reactions cause hemolysis?

    <p>Agglutination of red blood cells, leading to their destruction (C)</p> Signup and view all the answers

    What is the primary cause of acute renal shutdown in the context of hemoglobinuria?

    <p>All of the above. (D)</p> Signup and view all the answers

    What is the primary mechanism by which hemoglobin is removed from the bloodstream in the context of minor cases of hemoglobinuria?

    <p>It is reabsorbed by the tubular epithelium back into the blood. (A)</p> Signup and view all the answers

    Why can foreign cells transplanted into a recipient's body produce an immune reaction?

    <p>Foreign cells have antigens that are recognized as foreign by the recipient's immune system. (A)</p> Signup and view all the answers

    What is the role of the HLA complex in tissue transplantation?

    <p>It determines the likelihood of a transplant being rejected due to immune response. (C)</p> Signup and view all the answers

    Why is it so difficult to find a perfect match for tissue or organ transplantation?

    <p>Because each individual possesses a unique combination of HLA antigens. (B)</p> Signup and view all the answers

    What is the purpose of tissue typing in organ transplantation?

    <p>To assess the compatibility of the donor and recipient's HLA antigens. (B)</p> Signup and view all the answers

    Why are lymphocytes used for tissue typing in organ transplantation?

    <p>Lymphocytes express the same HLA antigens as other cells in the body. (C)</p> Signup and view all the answers

    Why is it important to identify the HLA antigens of both donor and recipient before transplantation?

    <p>To minimize the chances of rejection due to immune response. (D)</p> Signup and view all the answers

    What is the primary reason why most blood transfusion reactions occur?

    <p>The presence of strong antigens, such as the O-A-B system. (D)</p> Signup and view all the answers

    Why is the O allele considered recessive to both A and B alleles?

    <p>The O allele does not produce any agglutinogens, while A and B alleles do. (C)</p> Signup and view all the answers

    What is the primary function of the antigens on the surface of red blood cells (RBCs)?

    <p>Trigger immune responses and potentially cause blood transfusion reactions. (C)</p> Signup and view all the answers

    What is the significance of the O-A-B system of antigens in relation to blood transfusions?

    <p>It allows for the classification of blood types and helps prevent incompatible transfusions. (A)</p> Signup and view all the answers

    Which of the following genotypes is NOT a possible combination in the O-A-B blood group system?

    <p>AO (A)</p> Signup and view all the answers

    Which blood type is associated with the production of both type A and type B agglutinogens?

    <p>Blood type AB (D)</p> Signup and view all the answers

    What is the significance of the statement that the A and B alleles show codominance?

    <p>Both alleles are equally expressed in individuals with both the A and B alleles. (D)</p> Signup and view all the answers

    Why is it essential to consider the O-A-B system and Rh system when determining blood compatibility for transfusions?

    <p>These systems determine the presence of antigens that can cause agglutination and transfusion reactions. (C)</p> Signup and view all the answers

    If an individual's blood sample shows agglutination with both anti-A and anti-B agglutinins, what is their blood type?

    <p>AB (D)</p> Signup and view all the answers

    What is the primary function of anti-A and anti-B agglutinins in blood typing?

    <p>To cause red blood cells to clump together (agglutinate). (C)</p> Signup and view all the answers

    In the context of Rh factor, what does 'Rh-negative' mean?

    <p>The individual lacks the Rh antigen on their red blood cells. (B)</p> Signup and view all the answers

    Why is the formation of anti-Rh agglutinins a concern for Rh-negative individuals?

    <p>It can cause a severe immune response during subsequent Rh-positive blood transfusions. (B)</p> Signup and view all the answers

    Which blood type has both A and B agglutinogens?

    <p>Type AB (A)</p> Signup and view all the answers

    During the blood typing process, what is the purpose of mixing a blood sample with anti-A agglutinin?

    <p>To determine if the individual has the A antigen on their red blood cells. (A)</p> Signup and view all the answers

    What occurs when an Rh-negative person receives a transfusion of Rh-positive blood for the first time?

    <p>The person develops antibodies to the Rh factor, but there is no immediate reaction. (D)</p> Signup and view all the answers

    How is the blood typing process typically done?

    <p>By observing if the red blood cells clump (agglutinate) when mixed with specific antibodies. (A)</p> Signup and view all the answers

    Why are people with blood type O often called 'universal donors'?

    <p>Their blood can be transfused into individuals with any other blood type without complications. (C)</p> Signup and view all the answers

    What is the main difference between the O-A-B blood type system and the Rh blood type system?

    <p>The O-A-B system involves spontaneous agglutinin development, while the Rh system requires sensitization. (D)</p> Signup and view all the answers

    Which of the following statements about Rh-negative individuals is TRUE?

    <p>They have a higher chance of developing hemolytic disease of the newborn than Rh-positive individuals. (C)</p> Signup and view all the answers

    What happens when an Rh-negative person who has already been sensitized to the Rh factor receives a transfusion of Rh-positive blood?

    <p>A severe, immediate transfusion reaction occurs. (B)</p> Signup and view all the answers

    What does the term "sensitized" mean in the context of the Rh blood type system?

    <p>The person has developed antibodies to the Rh factor. (A)</p> Signup and view all the answers

    What is erythroblastosis fetalis?

    <p>A condition where the fetus's red blood cells are destroyed by the mother's immune system. (B)</p> Signup and view all the answers

    What is the primary cause of erythroblastosis fetalis?

    <p>The mother's immune system attacking the fetus's Rh-positive red blood cells. (C)</p> Signup and view all the answers

    Which of the following statements is TRUE about type O blood?

    <p>Type O blood has antibodies to both A and B antigens. (A), Type O blood has neither A nor B agglutinogens. (D)</p> Signup and view all the answers

    Flashcards

    Alleles

    Variants of a gene that determine traits.

    Blood Types

    Classifications based on specific antigens present on red blood cells.

    Agglutinogens

    Antigens on blood cells causing agglutination.

    Genotypes

    Combination of alleles an individual possesses.

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    Co-dominance

    Both alleles express equally in the phenotype.

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    Recessive Allele

    An allele that does not show its trait when a dominant allele is present.

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    Rh System

    Another blood group system that determines the Rh factor.

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    Transfusion Reactions

    Agglutination or other immune responses during blood transfusions.

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    Agglutinins

    Antibodies in plasma that react with specific agglutinogens in RBCs.

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    Agglutination Process

    The clumping of RBCs due to agglutinins binding to agglutinogens.

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    Type A Blood

    Contains A agglutinogens and anti-B agglutinins.

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    Type B Blood

    Contains B agglutinogens and anti-A agglutinins.

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    Type O Blood

    Contains no agglutinogens but both anti-A and anti-B agglutinins.

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    Type AB Blood

    Contains both A and B agglutinogens but no agglutinins.

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    Hemolysis

    Destruction of agglutinated RBCs by phagocytic cells or distortion.

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    Type O RBCs

    Red blood cells with no agglutinogens, do not react with anti-A or anti-B.

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    Rh Factor Sensitization

    A process where Rh-negative becomes sensitized to Rh factor after exposure.

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    Rh Transfusion Reactions

    Immune reaction to Rh-positive blood in already sensitized Rh-negative individuals.

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    Erythroblastosis Fetalis

    A fetal disease causing agglutination and phagocytosis of RBCs due to Rh incompatibility.

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    Delayed Transfusion Reaction

    Reaction occurring when previously sensitized individuals receive Rh-positive blood.

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    RBC Types

    The four main blood types are O, A, B, and AB.

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    Agglutination Test

    A method to identify blood types by observing clumping.

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    Anti-A Agglutinins

    Antibodies that react with A type blood cells.

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    Anti-B Agglutinins

    Antibodies that react with B type blood cells.

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    Rh Factor

    A specific antigen that can be present on RBCs, influencing blood type.

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    Rh-negative

    Blood type where the Rh factor is absent.

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    Formation of Anti-Rh Agglutinins

    Develops when Rh-negative individuals are exposed to Rh-positive blood.

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    Reabsorption

    The process of tubular epithelium taking back substances into the blood.

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    Acute Renal Shutdown

    A sudden failure of kidneys to function properly.

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    Hemoglobin Precipitation

    The process where high concentrations of hemoglobin block kidney tubules.

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    Human Leukocyte Antigen (HLA)

    A complex of antigens crucial for tissue compatibility in transplants.

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    Tissue Typing

    Testing for HLA antigens to ensure compatibility before transplantation.

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    Graft Rejection

    Immune response against transplanted tissue or organs due to foreign antigens.

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    Antisera

    Serum containing antibodies used in testing for compatibility.

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    Lymphocytes

    White blood cells that play a key role in the immune response.

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    Kernicterus

    A type of brain damage due to high bilirubin levels in neonates.

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    Bilirubin

    A yellow pigment formed from the breakdown of hemoglobin.

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    Replacement Transfusion

    Procedure where a neonate's blood is replaced with Rh-negative blood.

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    Jaundice

    A yellowing of skin and eyes due to high bilirubin levels.

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    Phagocytosis

    Process where cells engulf and digest harmful particles.

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    Rh-positive Blood

    Blood type containing the Rh factor on red blood cells.

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    Acute Kidney Failure

    A severe reaction that can occur during blood transfusions, affecting kidney function.

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    Study Notes

    Blood Types, Transfusion, and Tissue/Organ Transplantation

    • Blood transfusions can cause immediate or delayed reactions, potentially leading to death if not handled carefully
    • Different blood types have different antigens and immune properties, causing antibodies in one type to react with antigens in another
    • Blood types are determined by the presence or absence of A and B antigens (agglutinogens)
    • Type O blood has neither A nor B antigens, while Type A has only A, Type B has only B, and Type AB has both
    • The ABO blood group is determined by three alleles (IA, IB, and i), which code for the A, B, and O antigens, respectively
    • The O allele is recessive, while A and B alleles show co-dominance
    • Each person inherits two alleles, resulting in six possible genotypes (OO, OA, OB, AA, BB, AB) and four major blood types
    • O blood type is prevalent (47%), followed by A (41%), then B (9%), and AB (3%)
    • Anti-A and Anti-B antibodies (agglutinins) are produced in the plasma if the corresponding antigen isn't present on the red blood cells.
    • Type O blood contains both Anti-A and Anti-B antibodies
    • Agglutination occurs when agglutinins bind to agglutinogens (antigens) causing clumping of red blood cells
    • Rh blood typing system has various antigen types with the D antigen being the most significant, responsible for Rh positive and negative individuals
    • Rh positive individuals have the D antigen on their red blood cells, while Rh negatives don't
    • Rh antibodies generally only develop post-exposure to the Rh antigen, such as in a transfusion reaction, rather than spontaneously, unlike the ABO cases.
    • Erythroblastosis fetalis is a condition where a Rh-negative mother and Rh-positive fetus can result in complications due to Rh incompatibility, leading to hemolysis.

    Transfusion Reactions

    • Mismatched blood transfusions can result in agglutination and hemolysis of transfused red blood cells
    • Agglutination is the clumping of red blood cells due to the binding of agglutinins to agglutinogens
    • Hemolysis is the destruction of red blood cells, releasing hemoglobin into the bloodstream
    • Delayed hemolysis is less common than immediate hemolysis
    • Kidney failure is a potential serious complication of mismatched blood transfusions.

    Transplantation

    • Transplantation of tissues and organs may trigger immune responses due to differences in antigens
    • Autografts (same individual) and isografts (identical twins) are less prone to rejection
    • Allografts (different individuals) and xenografts (different species) pose a greater risk of rejection
    • HLA (human leukocyte antigen) complex antigens on tissue cells play a key role
    • Attempts at preventing rejection include tissue typing to match HLA antigens as closely as possible
    • Immunosuppressive drugs can help prevent rejection

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    Test your knowledge on transfusion reactions and blood types with this quiz. Explore topics such as agglutinins, hemolysis, and the significance of different blood types in transfusion scenarios. Understand the mechanisms behind conditions like erythroblastosis fetalis and the management of bilirubin levels in infants.

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