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Questions and Answers
Which blood type contains both A and B agglutinogens but lacks agglutinins?
Which blood type contains both A and B agglutinogens but lacks agglutinins?
What is the primary cause of agglutination in a transfusion reaction?
What is the primary cause of agglutination in a transfusion reaction?
What is the significance of agglutinins having multiple binding sites?
What is the significance of agglutinins having multiple binding sites?
Immediately after birth, what is the typical quantity of agglutinins present in an infant's plasma?
Immediately after birth, what is the typical quantity of agglutinins present in an infant's plasma?
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What is the primary mechanism behind hemolysis in a transfusion reaction?
What is the primary mechanism behind hemolysis in a transfusion reaction?
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How does agglutination lead to the plugging of small blood vessels?
How does agglutination lead to the plugging of small blood vessels?
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In a transfusion reaction, what happens to the agglutinated RBCs?
In a transfusion reaction, what happens to the agglutinated RBCs?
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What is the primary cause of death in infants with erythroblastosis fetalis?
What is the primary cause of death in infants with erythroblastosis fetalis?
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What is the mechanism by which bilirubin causes damage to the brain in infants with erythroblastosis fetalis?
What is the mechanism by which bilirubin causes damage to the brain in infants with erythroblastosis fetalis?
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What is the primary goal of blood transfusions in treating erythroblastosis fetalis?
What is the primary goal of blood transfusions in treating erythroblastosis fetalis?
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What is the rationale for using Rh-negative blood for transfusions in infants with erythroblastosis fetalis?
What is the rationale for using Rh-negative blood for transfusions in infants with erythroblastosis fetalis?
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How does the body typically eliminate bilirubin?
How does the body typically eliminate bilirubin?
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What is the main reason why jaundice is less common in adults compared to infants?
What is the main reason why jaundice is less common in adults compared to infants?
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Why is kidney failure a potentially lethal consequence of transfusion reactions?
Why is kidney failure a potentially lethal consequence of transfusion reactions?
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What is the primary mechanism by which transfusion reactions cause hemolysis?
What is the primary mechanism by which transfusion reactions cause hemolysis?
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What is the primary cause of acute renal shutdown in the context of hemoglobinuria?
What is the primary cause of acute renal shutdown in the context of hemoglobinuria?
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What is the primary mechanism by which hemoglobin is removed from the bloodstream in the context of minor cases of hemoglobinuria?
What is the primary mechanism by which hemoglobin is removed from the bloodstream in the context of minor cases of hemoglobinuria?
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Why can foreign cells transplanted into a recipient's body produce an immune reaction?
Why can foreign cells transplanted into a recipient's body produce an immune reaction?
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What is the role of the HLA complex in tissue transplantation?
What is the role of the HLA complex in tissue transplantation?
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Why is it so difficult to find a perfect match for tissue or organ transplantation?
Why is it so difficult to find a perfect match for tissue or organ transplantation?
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What is the purpose of tissue typing in organ transplantation?
What is the purpose of tissue typing in organ transplantation?
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Why are lymphocytes used for tissue typing in organ transplantation?
Why are lymphocytes used for tissue typing in organ transplantation?
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Why is it important to identify the HLA antigens of both donor and recipient before transplantation?
Why is it important to identify the HLA antigens of both donor and recipient before transplantation?
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What is the primary reason why most blood transfusion reactions occur?
What is the primary reason why most blood transfusion reactions occur?
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Why is the O allele considered recessive to both A and B alleles?
Why is the O allele considered recessive to both A and B alleles?
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What is the primary function of the antigens on the surface of red blood cells (RBCs)?
What is the primary function of the antigens on the surface of red blood cells (RBCs)?
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What is the significance of the O-A-B system of antigens in relation to blood transfusions?
What is the significance of the O-A-B system of antigens in relation to blood transfusions?
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Which of the following genotypes is NOT a possible combination in the O-A-B blood group system?
Which of the following genotypes is NOT a possible combination in the O-A-B blood group system?
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Which blood type is associated with the production of both type A and type B agglutinogens?
Which blood type is associated with the production of both type A and type B agglutinogens?
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What is the significance of the statement that the A and B alleles show codominance?
What is the significance of the statement that the A and B alleles show codominance?
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Why is it essential to consider the O-A-B system and Rh system when determining blood compatibility for transfusions?
Why is it essential to consider the O-A-B system and Rh system when determining blood compatibility for transfusions?
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If an individual's blood sample shows agglutination with both anti-A and anti-B agglutinins, what is their blood type?
If an individual's blood sample shows agglutination with both anti-A and anti-B agglutinins, what is their blood type?
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What is the primary function of anti-A and anti-B agglutinins in blood typing?
What is the primary function of anti-A and anti-B agglutinins in blood typing?
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In the context of Rh factor, what does 'Rh-negative' mean?
In the context of Rh factor, what does 'Rh-negative' mean?
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Why is the formation of anti-Rh agglutinins a concern for Rh-negative individuals?
Why is the formation of anti-Rh agglutinins a concern for Rh-negative individuals?
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Which blood type has both A and B agglutinogens?
Which blood type has both A and B agglutinogens?
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During the blood typing process, what is the purpose of mixing a blood sample with anti-A agglutinin?
During the blood typing process, what is the purpose of mixing a blood sample with anti-A agglutinin?
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What occurs when an Rh-negative person receives a transfusion of Rh-positive blood for the first time?
What occurs when an Rh-negative person receives a transfusion of Rh-positive blood for the first time?
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How is the blood typing process typically done?
How is the blood typing process typically done?
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Why are people with blood type O often called 'universal donors'?
Why are people with blood type O often called 'universal donors'?
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What is the main difference between the O-A-B blood type system and the Rh blood type system?
What is the main difference between the O-A-B blood type system and the Rh blood type system?
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Which of the following statements about Rh-negative individuals is TRUE?
Which of the following statements about Rh-negative individuals is TRUE?
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What happens when an Rh-negative person who has already been sensitized to the Rh factor receives a transfusion of Rh-positive blood?
What happens when an Rh-negative person who has already been sensitized to the Rh factor receives a transfusion of Rh-positive blood?
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What does the term "sensitized" mean in the context of the Rh blood type system?
What does the term "sensitized" mean in the context of the Rh blood type system?
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What is erythroblastosis fetalis?
What is erythroblastosis fetalis?
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What is the primary cause of erythroblastosis fetalis?
What is the primary cause of erythroblastosis fetalis?
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Which of the following statements is TRUE about type O blood?
Which of the following statements is TRUE about type O blood?
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Flashcards
Alleles
Alleles
Variants of a gene that determine traits.
Blood Types
Blood Types
Classifications based on specific antigens present on red blood cells.
Agglutinogens
Agglutinogens
Antigens on blood cells causing agglutination.
Genotypes
Genotypes
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Co-dominance
Co-dominance
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Recessive Allele
Recessive Allele
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Rh System
Rh System
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Transfusion Reactions
Transfusion Reactions
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Agglutinins
Agglutinins
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Agglutination Process
Agglutination Process
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Type A Blood
Type A Blood
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Type B Blood
Type B Blood
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Type O Blood
Type O Blood
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Type AB Blood
Type AB Blood
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Hemolysis
Hemolysis
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Type O RBCs
Type O RBCs
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Rh Factor Sensitization
Rh Factor Sensitization
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Rh Transfusion Reactions
Rh Transfusion Reactions
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Erythroblastosis Fetalis
Erythroblastosis Fetalis
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Delayed Transfusion Reaction
Delayed Transfusion Reaction
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RBC Types
RBC Types
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Agglutination Test
Agglutination Test
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Anti-A Agglutinins
Anti-A Agglutinins
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Anti-B Agglutinins
Anti-B Agglutinins
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Rh Factor
Rh Factor
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Rh-negative
Rh-negative
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Formation of Anti-Rh Agglutinins
Formation of Anti-Rh Agglutinins
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Reabsorption
Reabsorption
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Acute Renal Shutdown
Acute Renal Shutdown
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Hemoglobin Precipitation
Hemoglobin Precipitation
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Human Leukocyte Antigen (HLA)
Human Leukocyte Antigen (HLA)
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Tissue Typing
Tissue Typing
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Graft Rejection
Graft Rejection
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Antisera
Antisera
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Lymphocytes
Lymphocytes
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Kernicterus
Kernicterus
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Bilirubin
Bilirubin
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Replacement Transfusion
Replacement Transfusion
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Jaundice
Jaundice
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Phagocytosis
Phagocytosis
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Rh-positive Blood
Rh-positive Blood
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Acute Kidney Failure
Acute Kidney Failure
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Study Notes
Blood Types, Transfusion, and Tissue/Organ Transplantation
- Blood transfusions can cause immediate or delayed reactions, potentially leading to death if not handled carefully
- Different blood types have different antigens and immune properties, causing antibodies in one type to react with antigens in another
- Blood types are determined by the presence or absence of A and B antigens (agglutinogens)
- Type O blood has neither A nor B antigens, while Type A has only A, Type B has only B, and Type AB has both
- The ABO blood group is determined by three alleles (IA, IB, and i), which code for the A, B, and O antigens, respectively
- The O allele is recessive, while A and B alleles show co-dominance
- Each person inherits two alleles, resulting in six possible genotypes (OO, OA, OB, AA, BB, AB) and four major blood types
- O blood type is prevalent (47%), followed by A (41%), then B (9%), and AB (3%)
- Anti-A and Anti-B antibodies (agglutinins) are produced in the plasma if the corresponding antigen isn't present on the red blood cells.
- Type O blood contains both Anti-A and Anti-B antibodies
- Agglutination occurs when agglutinins bind to agglutinogens (antigens) causing clumping of red blood cells
- Rh blood typing system has various antigen types with the D antigen being the most significant, responsible for Rh positive and negative individuals
- Rh positive individuals have the D antigen on their red blood cells, while Rh negatives don't
- Rh antibodies generally only develop post-exposure to the Rh antigen, such as in a transfusion reaction, rather than spontaneously, unlike the ABO cases.
- Erythroblastosis fetalis is a condition where a Rh-negative mother and Rh-positive fetus can result in complications due to Rh incompatibility, leading to hemolysis.
Transfusion Reactions
- Mismatched blood transfusions can result in agglutination and hemolysis of transfused red blood cells
- Agglutination is the clumping of red blood cells due to the binding of agglutinins to agglutinogens
- Hemolysis is the destruction of red blood cells, releasing hemoglobin into the bloodstream
- Delayed hemolysis is less common than immediate hemolysis
- Kidney failure is a potential serious complication of mismatched blood transfusions.
Transplantation
- Transplantation of tissues and organs may trigger immune responses due to differences in antigens
- Autografts (same individual) and isografts (identical twins) are less prone to rejection
- Allografts (different individuals) and xenografts (different species) pose a greater risk of rejection
- HLA (human leukocyte antigen) complex antigens on tissue cells play a key role
- Attempts at preventing rejection include tissue typing to match HLA antigens as closely as possible
- Immunosuppressive drugs can help prevent rejection
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Description
Test your knowledge on transfusion reactions and blood types with this quiz. Explore topics such as agglutinins, hemolysis, and the significance of different blood types in transfusion scenarios. Understand the mechanisms behind conditions like erythroblastosis fetalis and the management of bilirubin levels in infants.