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Questions and Answers
What type of antibodies are found in the plasma of subjects whose red cells lack the corresponding antigen?
What type of antibodies are found in the plasma of subjects whose red cells lack the corresponding antigen?
Naturally occurring antibodies to A and/or B antigens
What is the characteristic of immune antibodies in terms of their development?
What is the characteristic of immune antibodies in terms of their development?
They develop in response to an antigen
What is the significance of naturally occurring antibodies to A and/or B antigens?
What is the significance of naturally occurring antibodies to A and/or B antigens?
They are important in the context of blood transfusion compatibility
Why are naturally occurring antibodies to A and/or B antigens found in the plasma of some individuals?
Why are naturally occurring antibodies to A and/or B antigens found in the plasma of some individuals?
What is the difference between naturally occurring antibodies and immune antibodies?
What is the difference between naturally occurring antibodies and immune antibodies?
What carbohydrate is bonded to ceramide in the H antigen structure on RBCs?
What carbohydrate is bonded to ceramide in the H antigen structure on RBCs?
Which monosaccharide is found at the terminal end of the H antigen structure on RBCs?
Which monosaccharide is found at the terminal end of the H antigen structure on RBCs?
What is the sequence of sugars attached to ceramide in the H antigen structure?
What is the sequence of sugars attached to ceramide in the H antigen structure?
Which nitrogen-containing sugar is present in the H antigen structure on RBCs?
Which nitrogen-containing sugar is present in the H antigen structure on RBCs?
What is the first carbohydrate attached to ceramide in the H antigen structure of RBCs?
What is the first carbohydrate attached to ceramide in the H antigen structure of RBCs?
What is the significance of detecting IgG anti-A, anti-B, or anti-A,B in a pregnant woman's serum?
What is the significance of detecting IgG anti-A, anti-B, or anti-A,B in a pregnant woman's serum?
In which scenario is the detection of IgG anti-A, anti-B, or anti-A,B in a woman's serum particularly important?
In which scenario is the detection of IgG anti-A, anti-B, or anti-A,B in a woman's serum particularly important?
What is the role of IgG anti-A, anti-B, or anti-A,B in the diagnosis of HDFN?
What is the role of IgG anti-A, anti-B, or anti-A,B in the diagnosis of HDFN?
Why is it essential to detect IgG anti-A, anti-B, or anti-A,B in a pregnant woman's serum?
Why is it essential to detect IgG anti-A, anti-B, or anti-A,B in a pregnant woman's serum?
What is the significance of IgG anti-A, anti-B, or anti-A,B in the context of maternal-fetal medicine?
What is the significance of IgG anti-A, anti-B, or anti-A,B in the context of maternal-fetal medicine?
Based on the reactivity with anti-H lectin, arrange the blood groups from the greatest to the least amount of H?
Based on the reactivity with anti-H lectin, arrange the blood groups from the greatest to the least amount of H?
What is the significance of the amount of H in determining the reactivity of anti-H lectin with different blood groups?
What is the significance of the amount of H in determining the reactivity of anti-H lectin with different blood groups?
How does the reactivity of anti-H lectin with different blood groups relate to the presence of H antigen?
How does the reactivity of anti-H lectin with different blood groups relate to the presence of H antigen?
What is the implication of the reactivity of anti-H lectin with different blood groups in transfusion medicine?
What is the implication of the reactivity of anti-H lectin with different blood groups in transfusion medicine?
How does the amount of H antigen on the surface of red blood cells influence the immune response to anti-H lectin?
How does the amount of H antigen on the surface of red blood cells influence the immune response to anti-H lectin?
What are the two main blood group systems that define an individual's blood type?
What are the two main blood group systems that define an individual's blood type?
What is the primary function of blood group antibodies in transfusion medicine?
What is the primary function of blood group antibodies in transfusion medicine?
Why is it essential to identify and match the ABO blood group in blood transfusions?
Why is it essential to identify and match the ABO blood group in blood transfusions?
What is the significance of the Rh blood group system in pregnancy and transfusion medicine?
What is the significance of the Rh blood group system in pregnancy and transfusion medicine?
What is the primary goal of identifying red cell antigens in transfusion medicine?
What is the primary goal of identifying red cell antigens in transfusion medicine?
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Study Notes
Transfusion Medicine 2
Red Cell Antigens and Blood Group Antibodies
- Red cell antigens include ABO and Rh systems
- Naturally occurring antibodies to A and/or B antigens are found in the plasma of subjects whose red cells lack the corresponding antigen
H Antigen Structure
- H antigen on RBC is composed of:
- Ceramide
- Glucose
- D-galactose
- N-acetylglucosamine
- D-galactose
- Fucose
Prediction and Diagnosis of HDFN
- Knowing the amount of IgG anti-A, anti-B, or anti-A,B in a woman's serum allows prediction or diagnosis of HDFN caused by ABO incompatibility
Reactivity with Anti-H Lectin
- Blood groups can be arranged from greatest to least reactivity with anti-H lectin:
- Greatest amount of H: ?
- Least amount of H: ?
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