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Blood Group Systems and Transfusion Reactions

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Blood Group Systems and Transfusion Reactions

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Questions and Answers

What is the primary role of the red blood cells in the Ag-Ab reaction?

To provide antibodies

To facilitate incubation

To store fibrinogen

To act as antigens (correct)

What happens to the reactivity of properly stored red cells?

It improves (correct)

It decreases

It remains the same

It becomes unpredictable

What is the purpose of washing red cells repeatedly?

To change the pH of the blood

To increase the ionic strength

To remove excess antibodies

To get rid of plasma containing fibrinogen (correct)

What is the typical storage location of antibodies?

In the serum Signup and view all the answers

What is the optimal temperature range for IgM antibodies?

4-25°C, known as 'cold' antibody Signup and view all the answers

What is the average incubation time for the Ag-Ab reaction?

60 minutes Signup and view all the answers

What is the effect of LISS (Low-ionic strength solution) on the Ag-Ab reaction?

It increases the rate of antibody uptake Signup and view all the answers

What is the optimal pH range for the Ag-Ab reaction?

6.5-7.5 Signup and view all the answers

What is the purpose of having a dilute solution of cells in the Ag-Ab reaction?

To ensure proper saturation of antigen sites with antibody molecules Signup and view all the answers

What is the effect of the negative electric charge (zeta potential) of erythrocytes?

It keeps the cells apart Signup and view all the answers