5 Questions
Which antibodies are sometimes implicated in delayed haemolytic reactions?
Kidd antibodies
What is the main cause of delayed haemolytic reactions after transfusion?
Recipient red cell antibodies too weak for detection
What type of haemolytic reactions involve antibodies that do not activate complement?
Extravascular haemolytic reactions
What is the cause of extravascular haemolytic reactions?
Antibodies that do not activate complement
What is a suspected sign of delayed haemolytic reaction when no immediate reaction occurs after transfusion?
Hb fails to increase after transfusion
Study Notes
Hazards of Transfusion
- Hazards can affect both the donor and the recipient/patient
Transfusion Risks and Adverse Reactions
- Many signs and symptoms of transfusion reactions are similar
- All reactions should be taken seriously
- Common reactions include:
- Allergic reactions (not life-threatening)
- Febrile reactions (respond to treatment)
- Reactions that cause the most concern include:
- Transfusion-related acute lung injury (TRALI)
- ABO mismatch
- TA-GvHD
- Sepsis
ABO Incompatible Blood
- ABO incompatible blood can lead to serious consequences
- Precautions should be taken during:
- Collection of blood specimen
- Cross-matching procedures
- At the time of issue
- At the time of infusion of the cross-matched unit of blood (ensure no error in patient identification)
Haemolytic Reactions
- Haemolytic transfusion reaction occurs when transfused red cells are destroyed in the recipient
- Reactions can be either acute or delayed, and cell destruction can be either intra- or extravascular
Acute Reactions
- Reactions that occur shortly after the start of the transfusion are termed acute
Learn about the hazards and adverse reactions associated with blood transfusions, including risks to both donors and recipients. Understand the signs, symptoms, and seriousness of transfusion reactions.
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