tPA Administration for Stroke Treatment
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Questions and Answers

Which trial formed the basis for the original 3-hour time window for tPA administration?

  • NINDS trial (correct)
  • National Institute of Neurological Disorders and Stroke
  • European Cooperative Acute Stroke Study (ECASS) I
  • Alteplase Thrombolysis for Acute Noninterventional Therapy in Ischemic Stroke

What is the maximum time window for tPA administration in a select group of patients?

  • 4 hours
  • 3 hours
  • 4.5 hours (correct)
  • 2 hours

What is the absolute risk increase in symptomatic intracerebral hemorrhage (ICH) with IV tPA within 3 hours of symptom onset?

  • 7%
  • 8%
  • 9%
  • 6% (correct)

What is the number needed to treat to achieve good recovery in one patient who would have otherwise had a poor outcome with tPA administration within 3 hours of symptom onset?

<p>8 patients (A)</p> Signup and view all the answers

What did the pooled analysis of the Alteplase Thrombolysis for Acute Noninterventional Therapy in Ischemic Stroke, European Cooperative Acute Stroke Study (ECASS) I and II, and NINDS trials show?

<p>tPA administration up to 4.5 hours is effective (B)</p> Signup and view all the answers

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