Relative Contraindications for IV tPA Treatment Quiz
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Questions and Answers

Which of the following is NOT considered a relative contraindication for IV tPA treatment in patients with minor or resolving deficits?

  • Seizures (correct)
  • Rapidly resolving deficit
  • Hypo- or hyperglycemia
  • Minor symptoms
  • What is the main concern when considering IV tPA treatment for patients with seizure at time of presentation?

  • Treating a stroke mimic (correct)
  • Risk of hemorrhagic conversion
  • Onset seizures
  • Rate of hemorrhagic complications
  • Why should blood glucose be measured and corrected in all patients?

  • To prevent neurologic deficits (correct)
  • To treat a stroke mimic
  • To mimic acute stroke
  • To increase the risk of hemorrhagic conversion
  • What did a subanalysis of the NINDS trial confirm about IV tPA treatment in patients with minor or resolving deficits?

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    Study Notes

    IV tPA Treatment Contraindications and Considerations

    • Relative contraindications for IV tPA treatment in patients with minor or resolving deficits include advanced age, history of stroke or transient ischemic attack, diabetes, and hypertension, but NOT isolated aphasia.
    • The main concern when considering IV tPA treatment for patients with seizure at time of presentation is post-ictal hemorrhage.
    • Blood glucose should be measured and corrected in all patients to prevent exacerbation of ischemic injury.
    • A subanalysis of the NINDS trial confirmed that IV tPA treatment in patients with minor or resolving deficits is safe and effective.

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    Identify Relative Contraindications for IV tPA Treatment

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