Tissue Plasminogen Activator (tPA) Quiz

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Questions and Answers

What is the generic name of the medication described in the text?

  • Alteplase (correct)
  • Activase
  • Thrombolytic enzyme
  • Plasminogen

What is the classification of the medication?

  • Plasminogen
  • Fibrinolysis
  • Thrombolytic enzyme (correct)
  • Activase

What is the indication for the use of this medication in the management of acute MI?

  • Dissolution of fibrin clots
  • Lysis of thrombi obstructing coronary arteries (correct)
  • Prevention of thrombi formation
  • Activation of plasminogen

What is the dosage of the medication for a patient weighing more than 67 kg experiencing STEMI symptoms for 6-12 hours?

<p>15 mg initial IV bolus; followed by 50 mg infused over the next 30 mins; then 35 mg infused over the next 60 mins (B)</p> Signup and view all the answers

What is the contraindication related to blood glucose level for administering the medication?

<p>Ensure BGL is above 3 (C)</p> Signup and view all the answers

What is the primary action of tissue plasminogen activator (tPA) on a thrombus?

<p>Binds to fibrin in a thrombus and converts entrapped plasminogen to plasmin, initiating fibrinolysis (B)</p> Signup and view all the answers

What is the primary pharmacodynamic action of tissue plasminogen activator (tPA) on fibrin clots?

<p>Degrades fibrin clots, fibrinogen and other plasma proteins (C)</p> Signup and view all the answers

What is the dosage of the medication for a patient aged 18-80 with acute ischemic stroke within 4.5 hours or wake-up and unknown time of onset?

<p>0.9 mg/kg (maximum 90 mg) IV, infused over 60 minutes; give 10% of total dose as an initial IV bolus over 1 min; give remaining 90% of total dose IV over next 60 minutes (D)</p> Signup and view all the answers

What is the action of tissue plasminogen activator (tPA) on plasminogen?

<p>Acts on plasminogen converting it to plasmin, which cleaves fibrin (A)</p> Signup and view all the answers

What is the indication for the use of this medication in the management of acute ischemic stroke?

<p>Lysis of thrombi obstructing cerebral arteries (C)</p> Signup and view all the answers

What is a relative contraindication for administering tissue plasminogen activator (tPA) in the management of acute ischemic stroke?

<p>History of chronic, severe, poorly controlled hypertension (D)</p> Signup and view all the answers

What is a contraindication for administering tPA in the management of acute ischemic stroke?

<p>Active bleeding or bleeding diathesis (D)</p> Signup and view all the answers

What is a contraindication for administering tPA in the management of acute MI?

<p>CPR greater than 10 mins (B)</p> Signup and view all the answers

What is a relative contraindication for administering tPA in the management of acute MI?

<p>Severe uncontrolled hypertension on presentation (SBP &gt; 180 mm Hg or DBP &gt;110 mm Hg) (B)</p> Signup and view all the answers

What is a contraindication for administering tPA in the management of stroke and MI?

<p>Non-compressible vascular punctures (C)</p> Signup and view all the answers

What is a relative contraindication for administering tPA in the management of stroke and MI?

<p>Recent GI or GU bleeding within 10 days (C)</p> Signup and view all the answers

What is a contraindication for administering tPA in the prehospital management of stroke and MI?

<p>Significant closed head trauma or facial trauma within 3 months (C)</p> Signup and view all the answers

What is a relative contraindication for administering tPA in the prehospital management of stroke and MI?

<p>Severe uncontrolled hypertension on presentation (SBP &gt; 185 mm Hg or DBP &gt;110 mm Hg) (A)</p> Signup and view all the answers

What is a contraindication for administering tPA in the prehospital management of stroke and MI?

<p>Recent internal bleeding within 2 to 4 weeks (C)</p> Signup and view all the answers

What is a relative contraindication for administering tPA in the prehospital management of stroke and MI?

<p>Recent GI or GU bleeding within 10 days (C)</p> Signup and view all the answers

Which of the following is a relative contraindication for the administration of tissue plasminogen activator (tPA) in the management of acute ischemic stroke?

<p>History of chronic, severe, poorly controlled hypertension (D)</p> Signup and view all the answers

What is a contraindication for the administration of tissue plasminogen activator (tPA) in the management of acute ischemic stroke?

<p>Ischemic stroke within 3 months (A)</p> Signup and view all the answers

What is a relative contraindication for the administration of tissue plasminogen activator (tPA) in the management of ST-elevation myocardial infarction (STEMI)?

<p>History of chronic, severe, poorly controlled hypertension (B)</p> Signup and view all the answers

What is a contraindication for the administration of tissue plasminogen activator (tPA) in the management of ST-elevation myocardial infarction (STEMI)?

<p>Active peptic ulcer (D)</p> Signup and view all the answers

What is a relative contraindication for the administration of tissue plasminogen activator (tPA) in the management of acute ischemic stroke?

<p>History of prior ischemic stroke &gt; 3 months, dementia, or known intracranial pathology not covered in contraindications (D)</p> Signup and view all the answers

What is a contraindication for the administration of tissue plasminogen activator (tPA) in the management of acute ischemic stroke?

<p>Recent (within 2 to 4 weeks) internal bleeding (D)</p> Signup and view all the answers

What is a relative contraindication for the administration of tissue plasminogen activator (tPA) in the management of acute ischemic stroke?

<p>Transient ischemic attack (TIA) within 6 months (B)</p> Signup and view all the answers

What is a contraindication for the administration of tissue plasminogen activator (tPA) in the management of ST-elevation myocardial infarction (STEMI)?

<p>Active bleeding or bleeding diathesis (A)</p> Signup and view all the answers

What is a relative contraindication for the administration of tissue plasminogen activator (tPA) in the management of ST-elevation myocardial infarction (STEMI)?

<p>Recent (within 2 to 4 weeks) internal bleeding (C)</p> Signup and view all the answers

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tPA (2023) PDF - Portage College Paramedic Program

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