Tissue Plasminogen Activator (tPA) Quiz

<p>15 mg initial IV bolus; followed by 50 mg infused over the next 30 mins; then 35 mg infused over the next 60 mins</p> Signup and view all the answers

<p>Ensure BGL is above 3</p> Signup and view all the answers

<p>Binds to fibrin in a thrombus and converts entrapped plasminogen to plasmin, initiating fibrinolysis</p> Signup and view all the answers

<p>Degrades fibrin clots, fibrinogen and other plasma proteins</p> Signup and view all the answers

<p>0.9 mg/kg (maximum 90 mg) IV, infused over 60 minutes; give 10% of total dose as an initial IV bolus over 1 min; give remaining 90% of total dose IV over next 60 minutes</p> Signup and view all the answers

<p>Acts on plasminogen converting it to plasmin, which cleaves fibrin</p> Signup and view all the answers

<p>Lysis of thrombi obstructing cerebral arteries</p> Signup and view all the answers

<p>History of chronic, severe, poorly controlled hypertension</p> Signup and view all the answers

<p>Active bleeding or bleeding diathesis</p> Signup and view all the answers

<p>CPR greater than 10 mins</p> Signup and view all the answers

<p>Severe uncontrolled hypertension on presentation (SBP &gt; 180 mm Hg or DBP &gt;110 mm Hg)</p> Signup and view all the answers

<p>Non-compressible vascular punctures</p> Signup and view all the answers

<p>Recent GI or GU bleeding within 10 days</p> Signup and view all the answers

<p>Significant closed head trauma or facial trauma within 3 months</p> Signup and view all the answers

<p>Severe uncontrolled hypertension on presentation (SBP &gt; 185 mm Hg or DBP &gt;110 mm Hg)</p> Signup and view all the answers

<p>Recent internal bleeding within 2 to 4 weeks</p> Signup and view all the answers

<p>Recent GI or GU bleeding within 10 days</p> Signup and view all the answers

<p>History of chronic, severe, poorly controlled hypertension</p> Signup and view all the answers

<p>Ischemic stroke within 3 months</p> Signup and view all the answers

<p>History of chronic, severe, poorly controlled hypertension</p> Signup and view all the answers

<p>Active peptic ulcer</p> Signup and view all the answers

<p>History of prior ischemic stroke &gt; 3 months, dementia, or known intracranial pathology not covered in contraindications</p> Signup and view all the answers

<p>Recent (within 2 to 4 weeks) internal bleeding</p> Signup and view all the answers

<p>Transient ischemic attack (TIA) within 6 months</p> Signup and view all the answers

<p>Active bleeding or bleeding diathesis</p> Signup and view all the answers

<p>Recent (within 2 to 4 weeks) internal bleeding</p> Signup and view all the answers